Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Large tumor suppressor homolog 2 (LATS2) | Literature-reported | Target Info | ||
| UniProt ID | LATS2_HUMAN | ||||
| Gene Name | LATS2 | ||||
| Gene ID | 26524 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Beta-catenin (CTNNB1) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Aurora kinase A (AURKA) | Target Info | PPI Info | [2] | |
| Interacting Literature-reported Target(s) | Large tumor suppressor homolog 2 (LATS2) | Target Info | PPI Info | [3] | |
| MST-1 protein kinase (STK4) | Target Info | PPI Info | [4] | ||
| Yes-associated protein 1 (YAP1) | Target Info | PPI Info | [5] | ||
| Angiomotin (AMOT) | Target Info | PPI Info | [4] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | LATS2 suppresses oncogenic Wnt signaling by disrupting -catenin/BCL9 interaction. Cell Rep. 2013 Dec 26;5(6):1650-63. | ||||
| REF 2 | The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. Cell Cycle. 2011 Aug 15;10(16):2724-36. | ||||
| REF 3 | Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Sci Signal. 2015 Feb 10;8(363):ra14. | ||||
| REF 4 | Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal. 2013 Nov 19;6(302):rs15. | ||||
| REF 5 | Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J. 2015 May 12;34(10):1349-70. | ||||
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