Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T47510 Target Info
Target Name Angiomotin (AMOT)
Synonyms KIAA1071
Target Type Literature-reported Target
Gene Name AMOT
UniProt ID
AMOT_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) Interacting Protein Interacting Protein Info
UniProt ID
NED4L_HUMAN 
Synonyms NEDD4.2; NEDD4.2; RSP5; hNEDD4.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase pez (PTPN14) Literature-reported Target Interacting Protein Info
UniProt ID
PTN14_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 14; PTPD2; PEZ
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [3]
Kinases [+] 1 Kinases +
Interacting Target Name Large tumor suppressor homolog 2 (LATS2) Literature-reported Target Interacting Protein Info
UniProt ID
LATS2_HUMAN 
Synonyms Warts-like kinase; Serine/threonine-protein kinase LATS2; Serine/threonine-protein kinase kpm; KPM; Kinase phosphorylated during mitosis protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Biochemical Activity [5]
3 Proximity Label-MS [4]
Microtubule-associated [+] 2 Microtubule-associated +
Interacting Protein Name MAGUK p55 subfamily member 5 (MPP5) Interacting Protein Interacting Protein Info
UniProt ID
MPP5_HUMAN 
Synonyms PALS1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [1]
4 Proximity Label-MS [4]
Interacting Protein Name MAGUK p55 subfamily member 7 (MPP7) Interacting Protein Interacting Protein Info
UniProt ID
MPP7_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [1]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Yes-associated protein 1 (YAP1) Literature-reported Target Interacting Protein Info
UniProt ID
YAP1_HUMAN 
Synonyms Yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; 65 kDa Yes-associated protein
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [9]
5 Reconstituted Complex [7]
Other proteins [+] 6 Other proteins +
Interacting Protein Name Angiomotin-like protein 1 (AMOTL1) Interacting Protein Interacting Protein Info
UniProt ID
AMOL1_HUMAN 
Synonyms JEAP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [10]
4 Proximity Label-MS [4]
Interacting Protein Name Multiple PDZ domain protein (MPDZ) Interacting Protein Interacting Protein Info
UniProt ID
MPDZ_HUMAN 
Synonyms HYC2; MUPP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [1]
4 Proximity Label-MS [4]
Interacting Protein Name InaD-like protein (PATJ) Interacting Protein Interacting Protein Info
UniProt ID
INADL_HUMAN 
Synonyms Cipp; InaD.like; PATJ; hINADL
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [6]
3 Proximity Label-MS [4]
Interacting Protein Name Neurofibromin-2 (NF2) Interacting Protein Interacting Protein Info
UniProt ID
MERL_HUMAN 
Synonyms ACN; BANF; SCH
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [11]
Interacting Target Name Melanoma-associated antigen 4 (MAGEA4) Clinical trial Target Interacting Protein Info
UniProt ID
MAGA4_HUMAN 
Synonyms MAGE-X2 antigen; MAGE-X2; MAGE-41 antigen; MAGE-41; MAGE-4 protein; MAGE-4 antigen; MAGE4; CT1.4; Cancer/testis antigen 1.4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Yeast two hybrid [13]
Interacting Protein Name Angiomotin-like protein 2 (AMOTL2) Interacting Protein Interacting Protein Info
UniProt ID
AMOL2_HUMAN 
Synonyms LCCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Proximity Label-MS [4]
References  Top
REF 1 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 2 Angiomotin functions in HIV-1 assembly and budding. Elife. 2015 Jan 29;4.
REF 3 PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1;26(17):1959-71.
REF 4 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal. 2013 Nov 19;6(302):rs15.
REF 5 Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17368-73.
REF 6 A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell. 2006 May 5;125(3):535-48.
REF 7 The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation. Biochem J. 2012 Jun 1;444(2):279-89.
REF 8 Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation. J Biol Chem. 2013 Dec 27;288(52):37296-307.
REF 9 Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. J Biol Chem. 2013 Nov 22;288(47):34041-51.
REF 10 Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. Mol Syst Biol. 2013 Dec 22;9:713.
REF 11 Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway. Cell Res. 2015 Jul;25(7):801-17.
REF 12 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 13 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.