Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T87675 Target Info
Target Name Aurora kinase A (AURKA)
Synonyms hARK1; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; STK6; STK15; IAK1; Breast tumor-amplified kinase; BTAK; Aurora/IPL1-related kinase 1; Aurora-related kinase 1; Aurora-A; Aurora 2; AYK1; AURA; ARK1; ARK-1; AIRK1; AIK
Target Type Clinical trial Target
Gene Name AURKA
Biochemical Class Kinase
UniProt ID
AURKA_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [1]
4 Reconstituted Complex [1]
Kinases [+] 1 Kinases +
Interacting Target Name Large tumor suppressor homolog 2 (LATS2) Literature-reported Target Interacting Protein Info
UniProt ID
LATS2_HUMAN 
Synonyms Warts-like kinase; Serine/threonine-protein kinase LATS2; Serine/threonine-protein kinase kpm; KPM; Kinase phosphorylated during mitosis protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Biochemical Activity [4]
4 Fluorescence Resonance Energy Transfer [5]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-MS [7]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [9]
5 Biochemical Activity [10]
6 Reconstituted Complex [9]
7 Yeast two hybrid [8]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name N-myc proto-oncogene protein (MYCN) Literature-reported Target Interacting Protein Info
UniProt ID
MYCN_HUMAN 
Synonyms N-myc; NMYC; Class E basic helix-loop-helix protein 37; bHLHe37
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Co-crystal Structure [12]
3 Reconstituted Complex [12]
Other proteins [+] 5 Other proteins +
Interacting Target Name Hepatocellular carcinoma-associated antigen 90 (TPX2) Literature-reported Target Interacting Protein Info
UniProt ID
TPX2_HUMAN 
Synonyms Restricted expression proliferation-associated protein 100; Protein fls353; Hepatocellular carcinoma-associated antigen 90; Hepatocellular carcinoma-associated antigen 519; HCA519; DIL-2; DIL2; Differentially expressed in cancerous and non-cancerous lung cells 2; C20orf2; C20orf1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [7]
4 Affinity Capture-Western [14]
5 Affinity Capture-Western [2]
6 Affinity Capture-Western [15]
7 Affinity Capture-Western [16]
8 Reconstituted Complex [14]
Interacting Protein Name Inner centromere protein (INCENP) Interacting Protein Interacting Protein Info
UniProt ID
INCE_HUMAN 
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [16]
3 Biochemical Activity [16]
4 Reconstituted Complex [15]
5 Reconstituted Complex [16]
Interacting Target Name Transforming acidic coiled-coil protein 3 (TACC3) Literature-reported Target Interacting Protein Info
UniProt ID
TACC3_HUMAN 
Synonyms Transforming acidic coiled-coil-containing protein 3; ERIC-1; ERIC1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-MS [7]
3 Biochemical Activity [17]
4 Yeast two hybrid [17]
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Biochemical Activity [19]
Interacting Protein Name Transcription elongation factor A protein-like 2 (TCEAL2) Interacting Protein Interacting Protein Info
UniProt ID
TCAL2_HUMAN 
Synonyms MY0876G05; WEX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Reconstituted Complex [21]
References  Top
REF 1 BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 2004 May 7;279(19):19643-8.
REF 2 Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol. 2011 Nov;9(11):e1001199.
REF 3 The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis. Cell Cycle. 2011 Aug 15;10(16):2724-36.
REF 4 The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells. 2004 May;9(5):383-97.
REF 5 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 6 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 7 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 8 Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. EMBO J. 2002 Sep 2;21(17):4491-9.
REF 9 Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 2004 Jan;36(1):55-62.
REF 10 A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2. Biochim Biophys Acta. 2013 Feb;1834(2):508-15.
REF 11 Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell. 2009 Jan 6;15(1):67-78.
REF 12 Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731.
REF 13 Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science. 2010 Apr 30;328(5978):593-9.
REF 14 Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol. 2002 Aug 19;158(4):617-23.
REF 15 Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Cell Cycle. 2008 Sep 1;7(17):2691-704.
REF 16 A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6939-44.
REF 17 Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol Cell Proteomics. 2004 Jan;3(1):93-104.
REF 18 Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. Oncogene. 2017 Jun 15;36(24):3450-3463.
REF 19 Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC). PLoS One. 2013 Jun 13;8(6):e67071.
REF 20 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531.
REF 21 Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. Oncogenesis. 2017 Feb 20;6(2):e298.

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