| References |
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| REF 1 |
Estrogen receptor protects p53 from deactivation by human double minute-2. Cancer Res. 2000 Apr 1;60(7):1810-4.
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| REF 2 |
Negative regulation of bcl-2 expression by p53 in hematopoietic cells. Oncogene. 2001 Jan 11;20(2):240-51.
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| REF 3 |
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
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| REF 4 |
Aprataxin, a novel protein that protects against genotoxic stress. Hum Mol Genet. 2004 May 15;13(10):1081-93.
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| REF 5 |
The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10355-60.
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| REF 6 |
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science. 2006 Aug 25;313(5790):1122-6.
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| REF 7 |
COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis. Biochem Biophys Res Commun. 2005 Mar 25;328(4):1107-12.
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| REF 8 |
Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7951-5.
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Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. EMBO J. 2004 Mar 10;23(5):1144-54.
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| REF 10 |
Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. EMBO J. 2002 Sep 2;21(17):4491-9.
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| REF 11 |
COP9 subunits 4 and 5 target soluble guanylyl cyclase 1 and p53 in prostate cancer cells. Mol Endocrinol. 2014 Jun;28(6):834-45.
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| REF 12 |
Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia. 2002 Mar-Apr;4(2):171-80.
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| REF 13 |
Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2). Biochem Biophys Res Commun. 2001 May 4;283(2):507-12.
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| REF 14 |
The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A. J Mol Biol. 2000 Jul 14;300(3):503-18.
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| REF 15 |
Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway. J Biol Chem. 2011 Mar 11;286(10):8565-76.
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| REF 16 |
Negative regulation of the deacetylase SIRT1 by DBC1. Nature. 2008 Jan 31;451(7178):587-90.
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| REF 17 |
TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner. Cell Cycle. 2006 Dec;5(23):2787-95.
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| REF 18 |
JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases. Oncogene. 1997 Nov 6;15(19):2277-87.
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| REF 19 |
NUMB controls p53 tumour suppressor activity. Nature. 2008 Jan 3;451(7174):76-80.
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| REF 20 |
Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins. Oncotarget. 2014 Sep 30;5(18):8452-65.
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| REF 21 |
ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet. 1998 Dec;20(4):398-400.
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| REF 22 |
A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint. Cell. 2005 Jul 15;122(1):21-32.
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| REF 23 |
Regulation of CAK kinase activity by p53. Oncogene. 1998 Nov 26;17(21):2733-41.
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| REF 24 |
Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells. Pharmacogenomics J. 2010 Apr;10(2):94-104.
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| REF 25 |
Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis. FEBS Lett. 2007 Jan 9;581(1):131-9.
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| REF 26 |
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008 Jan 18;29(1):9-22.
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| REF 27 |
p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol. 2008 Sep;28(17):5139-46.
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| REF 28 |
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature. 2002 Oct 24;419(6909):853-7.
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| REF 29 |
The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. J Biol Chem. 2003 Aug 29;278(35):33134-41.
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| REF 30 |
Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. J Biol Chem. 2010 Jan 22;285(4):2601-9.
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| REF 31 |
MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein. J Biol Chem. 2010 Dec 10;285(50):38818-31.
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| REF 32 |
Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 2005 Mar 23;24(6):1157-69.
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| REF 33 |
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem. 2003 Apr 18;278(16):13595-8.
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| REF 34 |
Autophagic degradation of the inhibitory p53 isoform 133p53 as a regulatory mechanism for p53-mediated senescence. Nat Commun. 2014 Aug 21;5:4706.
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| REF 35 |
Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation. Mol Cell Biol. 2002 Aug;22(16):6014-22.
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| REF 36 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
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| REF 37 |
Physical interaction between p53 and primary response gene Egr-1. Int J Oncol. 2001 Apr;18(4):863-70.
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| REF 38 |
Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol. 2002 Jul;4(7):529-33.
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| REF 39 |
DNA damage tolerance pathway involving DNA polymerase and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4311-9.
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| REF 40 |
A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy. J Biol Chem. 2002 Jan 25;277(4):2852-9.
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| REF 41 |
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol. 2003 Apr;23(8):2669-79.
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| REF 42 |
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002 Apr 11;416(6881):648-53.
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| REF 43 |
p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol Cell. 2006 May 5;22(3):395-405.
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| REF 44 |
Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway. J Cell Physiol. 2010 Nov;225(2):394-405.
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| REF 45 |
HSP90 Shapes the Consequences of Human Genetic Variation. Cell. 2017 Feb 23;168(5):856-866.e12.
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| REF 46 |
p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN. Cell Death Differ. 2014 Jan;21(1):146-60.
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| REF 47 |
The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. Mol Cell Proteomics. 2008 Mar;7(3):560-72.
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| REF 48 |
The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro. Oncogene. 1999 Apr 29;18(17):2690-702.
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| REF 49 |
PML enhances the regulation of p53 by CK1 in response to DNA damage. Oncogene. 2008 Jun 12;27(26):3653-61.
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| REF 50 |
Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. Mol Endocrinol. 2002 Feb;16(2):402-10.
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| REF 51 |
Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science. 2003 Apr 11;300(5617):342-4.
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| REF 52 |
Repression of p53 activity by Smyd2-mediated methylation. Nature. 2006 Nov 30;444(7119):629-32.
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| REF 53 |
Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem. 2008 Mar 1;103(4):1219-30.
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| REF 54 |
SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. J Biol Chem. 2002 Jun 21;277(25):22330-7.
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| REF 55 |
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell. 2005 Jun 17;121(6):873-85.
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| REF 56 |
Regulation of p53 target gene expression by peptidylarginine deiminase 4. Mol Cell Biol. 2008 Aug;28(15):4745-58.
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| REF 57 |
Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8797-801.
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| REF 58 |
Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-beta-mediated cancer cell invasiveness. Biochem J. 2010 Feb 24;426(3):327-35.
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| REF 59 |
Bladder polypoid cystitis-derived A20 associates with tumorigenesis. Cell Biochem Biophys. 2013 Nov;67(2):669-73.
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| REF 60 |
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol. 2004 May;6(5):443-50.
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| REF 61 |
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J Virol. 2006 May;80(9):4292-303.
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| REF 62 |
p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J. 1996 Apr 15;15(8):1992-2002.
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| REF 63 |
Interaction with p53 enhances binding of cisplatin-modified DNA by high mobility group 1 protein. J Biol Chem. 2001 Mar 9;276(10):7534-40.
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| REF 64 |
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol. 2002 Jan;4(1):1-10.
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| REF 65 |
Metastasis-associated protein 1 inhibits p53-induced apoptosis. Oncol Rep. 2007 Nov;18(5):1311-4.
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| REF 66 |
An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability. FEBS Lett. 2012 Apr 24;586(8):1135-40.
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| REF 67 |
Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochem Pharmacol. 2011 Dec 1;82(11):1630-40.
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| REF 68 |
Twist and p53 reciprocally regulate target genes via direct interaction. Oncogene. 2008 Sep 18;27(42):5543-53.
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| REF 69 |
Identifying biological pathways that underlie primordial short stature using network analysis. J Mol Endocrinol. 2014 Jun;52(3):333-44.
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| REF 70 |
A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68.
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| REF 71 |
Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. J Biol Chem. 2003 Feb 14;278(7):4981-9.
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| REF 72 |
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol. 2004 Sep 13;166(6):801-13.
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| REF 73 |
Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53. J Biol Chem. 2002 Nov 22;277(47):45028-33.
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| REF 74 |
SOCS1 links cytokine signaling to p53 and senescence. Mol Cell. 2009 Dec 11;36(5):754-67.
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| REF 75 |
Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell. 2003 May 2;113(3):301-14.
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