Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T92098 Target Info
Target Name Cyclic AMP-responsive element-binding protein (CREB1)
Synonyms cAMP-responsive element-binding protein 1; Cyclic AMP-responsive element-binding protein 1; Cyclic AMP responseelement-binding protein; CREB-1; CREB; CAMP-response element binding protein
Target Type Literature-reported Target
Gene Name CREB1
Biochemical Class Basic leucine zipper bZIP
UniProt ID
CREB1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [2]
3 Far Western [3]
4 Reconstituted Complex [4]
Kinases [+] 1 Kinases +
Interacting Target Name Ribosomal protein S6 kinase alpha-5 (RSK5) Patented-recorded Target Interacting Protein Info
UniProt ID
KS6A5_HUMAN 
Synonyms S6K-alpha-5; RSK-like protein kinase; RSKL; Nuclear mitogen- and stress-activated protein kinase 1; MSK1; 90 kDa ribosomal protein S6 kinase 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Reconstituted Complex [6]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-localization [8]
3 Reconstituted Complex [9]
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-crystal Structure [11]
3 Far Western [12]
4 Fluorescence Resonance Energy Transfer [13]
5 Reconstituted Complex [12]
6 Yeast two hybrid [14]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [16]
Interacting Protein Name cAMP-responsive element modulator (CREM) Interacting Protein Interacting Protein Info
UniProt ID
CREM_HUMAN 
Synonyms CREM.2; ICER; hCREM.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [17]
References  Top
REF 1 The prostaglandin transporter regulates adipogenesis and aromatase transcription. Cancer Prev Res (Phila). 2011 Feb;4(2):194-206.
REF 2 Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway. J Cell Biochem. 2011 Feb;112(2):559-70.
REF 3 Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature. 1995 Mar 2;374(6517):85-8.
REF 4 MyoD stimulates RB promoter activity via the CREB/p300 nuclear transduction pathway. Mol Cell Biol. 2003 Apr;23(8):2893-906.
REF 5 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998 Aug 3;17(15):4426-41.
REF 6 Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J. 2001 Aug 15;20(16):4370-9.
REF 7 Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J Virol. 2006 May;80(9):4292-303.
REF 8 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 9 p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation. Mol Cell Biol. 2000 Jul;20(13):4849-58.
REF 10 MTUS1 silencing promotes E-selectin production through p38 MAPK-dependent CREB ubiquitination in endothelial cells. J Mol Cell Cardiol. 2016 Dec;101:1-10.
REF 11 An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006 Aug 10;442(7103):700-4.
REF 12 Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9.
REF 13 Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators. J Biol Chem. 2002 Nov 1;277(44):42241-8.
REF 14 CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 1998 Dec 4;273(49):32377-9.
REF 15 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 16 Heterodimer formation between CREB and JUN proteins. Oncogene. 1990 Mar;5(3):295-302.
REF 17 Prostaglandin E2 modulates IL-8 expression through formation of a multiprotein enhanceosome in human colonic epithelial cells. Eur J Immunol. 2012 Apr;42(4):912-23.

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