Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T06800 Target Info
Target Name Suppressor of cytokine signaling 1 (SOCS1)
Synonyms Tec-interacting protein 3; TIP3; TIP-3; STAT-induced STAT inhibitor 1; STAT induced STAT inhibitor 1; SSI1; SSI-1; SOCS-1; JAK-binding protein; JAB
Target Type Literature-reported Target
Gene Name SOCS1
UniProt ID
SOCS1_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 2 Kinases +
Interacting Target Name Janus kinase 2 (JAK-2) Successful Target Interacting Protein Info
UniProt ID
JAK2_HUMAN 
Synonyms Tyrosine-protein kinase JAK2
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Reconstituted Complex [4]
8 Reconstituted Complex [3]
9 Reconstituted Complex [7]
Interacting Target Name Apoptosis signal-regulating kinase 1 (MAP3K5) Clinical trial Target Interacting Protein Info
UniProt ID
M3K5_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 5; MEKK5; MEKK 5; MEK kinase 5; MAPKKK5; MAPK/ERK kinase kinase 5; ASK-1; ASK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [8]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [10]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [13]
Other proteins [+] 1 Other proteins +
Interacting Target Name Proto-oncogene c-Crk (c-Crk) Literature-reported Target Interacting Protein Info
UniProt ID
CRK_HUMAN 
Synonyms P38; Adapter molecule crk
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [14]
2 Yeast two hybrid [15]
References  Top
REF 1 Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor. Endocrinology. 2001 Dec;142(12):5286-93.
REF 2 The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells. Oncogene. 2001 Feb 15;20(7):849-58.
REF 3 The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 1999 Mar 1;18(5):1309-20.
REF 4 A new protein containing an SH2 domain that inhibits JAK kinases. Nature. 1997 Jun 26;387(6636):921-4.
REF 5 Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. J Biol Chem. 1999 Aug 27;274(35):24497-502.
REF 6 Elongin B/C recruitment regulates substrate binding by CIS. J Biol Chem. 2008 Aug 1;283(31):21334-46.
REF 7 Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. J Biol Chem. 2017 Apr 28;292(17):6895-6909.
REF 8 SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation. J Biol Chem. 2006 Mar 3;281(9):5559-66.
REF 9 IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. Am J Respir Cell Mol Biol. 2009 Mar;40(3):314-24.
REF 10 SOCS1 links cytokine signaling to p53 and senescence. Mol Cell. 2009 Dec 11;36(5):754-67.
REF 11 Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus. FASEB J. 2011 Mar;25(3):863-74.
REF 12 Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 2003 Dec;12(6):1413-26.
REF 13 COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. EMBO J. 2007 Jan 24;26(2):436-47.
REF 14 Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 1999 Feb 15;18(4):904-15.
REF 15 Phospho-tyrosine dependent protein-protein interaction network. Mol Syst Biol. 2015 Mar 26;11(3):794.

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