| References |
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| REF 1 |
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature. 2000 Mar 9;404(6774):201-4.
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| REF 2 |
BRCA1 is regulated by Chk2 in response to spindle damage. Biochim Biophys Acta. 2008 Dec;1783(12):2223-33.
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| REF 3 |
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007 Apr 18;26(8):2083-93.
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| REF 4 |
Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer Res. 2002 Nov 15;62(22):6357-61.
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| REF 5 |
Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase. J Biol Chem. 2008 Jul 11;283(28):19322-8.
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| REF 6 |
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell. 2003 Mar;3(3):247-58.
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| REF 7 |
Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. J Biol Chem. 2003 Aug 8;278(32):29824-9.
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| REF 8 |
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. 2001 Apr 12;410(6830):842-7.
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| REF 9 |
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem. 2003 Mar 7;278(10):8468-75.
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| REF 10 |
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science. 2004 Apr 2;304(5667):93-6.
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| REF 11 |
The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. J Biol Chem. 2003 Aug 29;278(35):33134-41.
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| REF 12 |
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 2000 Feb 1;14(3):289-300.
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| REF 13 |
HDM2 negatively affects the Chk2-mediated phosphorylation of p53. FEBS Lett. 2005 May 9;579(12):2604-8.
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| REF 14 |
DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science. 2000 Mar 10;287(5459):1824-7.
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| REF 15 |
ATM and Chk2 kinase target the p53 cofactor Strap. EMBO Rep. 2008 Dec;9(12):1222-9.
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| REF 16 |
Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities. Cell Cycle. 2009 Feb 1;8(3):430-7.
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| REF 17 |
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol Cell Biol. 2006 Sep;26(18):6819-31.
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| REF 18 |
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6.
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| REF 19 |
Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies. Biochem Biophys Res Commun. 2003 Nov 28;311(4):803-8.
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| REF 20 |
REGgamma/PA28gamma proteasome activator interacts with PML and Chk2 and affects PML nuclear bodies number. Cell Cycle. 2009 Aug;8(15):2399-407.
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| REF 21 |
Chk2 and REG-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic Acids Res. 2014 Dec 1;42(21):13150-60.
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