Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Breast cancer type 2 susceptibility protein (BRCA2) | Literature-reported | Target Info | ||
| UniProt ID | BRCA2_HUMAN | ||||
| Gene Name | BRCA2 | ||||
| Gene ID | 675 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Polo-like kinase 1 (PLK1) | Target Info | PPI Info | [1] | |
| Serine/threonine-protein kinase Chk2 (RAD53) | Target Info | PPI Info | [2] | ||
| DNA repair protein RAD51 homolog 1 (RAD51) | Target Info | PPI Info | [4] | ||
| Interacting Literature-reported Target(s) | Histone acetyltransferase KAT2B (KAT2B) | Target Info | PPI Info | [3] | |
| Gamma-Histone H2AX (H2AFX) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression. Oncogene. 2004 Jan 29;23(4):865-72. | ||||
| REF 2 | ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. | ||||
| REF 3 | BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene. 1998 Nov 12;17(19):2531-4. | ||||
| REF 4 | Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Mol Cell. 2015 Jul 16;59(2):176-87. | ||||
| REF 5 | FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell. 2008 Apr 11;30(1):86-97. | ||||
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