Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T40694 Target Info
Target Name Polo-like kinase 1 (PLK1)
Synonyms Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; Serine-threonine protein kinase 13; STPK13; Plk1; PLK-1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
Target Type Clinical trial Target
Gene Name PLK1
Biochemical Class Kinase
UniProt ID
PLK1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase Topors (TOPORS) Interacting Protein Interacting Protein Info
UniProt ID
TOPRS_HUMAN 
Synonyms LUN; P53BP3; RP31; TP53BPL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name Kelch-like protein 22 (KLHL22) Interacting Protein Interacting Protein Info
UniProt ID
KLH22_HUMAN 
Synonyms KELCHL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Interacting Protein Name TRAF family member-associated NF-kappa-B activator (TANK) Interacting Protein Interacting Protein Info
UniProt ID
TANK_HUMAN 
Synonyms I.TRAF; ITRAF; TRAF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Yeast two hybrid [5]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Cell division cycle protein 20 homolog (CDC20) Interacting Protein Interacting Protein Info
UniProt ID
CDC20_HUMAN 
Synonyms CDC20A; bA276H19.3; p55CDC
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Biochemical Activity [6]
Ester hydrolases [+] 3 Ester hydrolases +
Interacting Target Name M-phase inducer phosphatase 3 (MPIP3) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP3_HUMAN 
Synonyms Dual specificity phosphatase Cdc25C; Cdc25C phosphatase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [8]
Interacting Protein Name DNA repair endonuclease XPF (ERCC4) Interacting Protein Interacting Protein Info
UniProt ID
XPF_HUMAN 
Synonyms ERCC11; FANCQ; RAD1; XPF
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
Interacting Target Name Protein-tyrosine phosphatase pez (PTPN14) Literature-reported Target Interacting Protein Info
UniProt ID
PTN14_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 14; PTPD2; PEZ
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [11]
Isomerases [+] 1 Isomerases +
Interacting Target Name Rotamase Pin1 (PIN1) Clinical trial Target Interacting Protein Info
UniProt ID
PIN1_HUMAN 
Synonyms Prolyl isomerase Pin1; PPIase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Biochemical Activity [13]
3 Far Western [12]
4 Reconstituted Complex [13]
Kinases [+] 2 Kinases +
Interacting Protein Name Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) Interacting Protein Interacting Protein Info
UniProt ID
BUB1B_HUMAN 
Synonyms BUB1beta; BUBR1; Bub1A; MAD3L; MVA1; SSK1; hBUBR1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [14]
3 Reconstituted Complex [14]
Interacting Target Name Serine/threonine-protein kinase Chk2 (RAD53) Clinical trial Target Interacting Protein Info
UniProt ID
CHK2_HUMAN 
Synonyms Hucds1; hCds1; CHK2 checkpoint homolog; CHK2; Checkpoint kinase 2; Cds1 homolog; Cds1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Biochemical Activity [15]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Heat shock protein 70 (HSP70) Clinical trial Target Interacting Protein Info
UniProt ID
HSF1_HUMAN 
Synonyms Molecular chaperone Hsp70; HSTF1; HSTF 1; HSP70; HSF 1; Heat shock transcription factor 1; Heat shock factor protein 1; Heat shock 70 kDa protein; Chaperone protein dnaK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [17]
3 Biochemical Activity [17]
Other proteins [+] 4 Other proteins +
Interacting Target Name Breast cancer type 2 susceptibility protein (BRCA2) Literature-reported Target Interacting Protein Info
UniProt ID
BRCA2_HUMAN 
Synonyms Fanconi anemia group D1 protein; FANCD1; FACD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Biochemical Activity [19]
3 Reconstituted Complex [19]
Interacting Target Name Tumor suppressor p53-binding protein 1 (TP53BP1) Literature-reported Target Interacting Protein Info
UniProt ID
TP53B_HUMAN 
Synonyms TP53-binding protein 1; p53BP1; p53-binding protein 1; 53BP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [20]
2 Reconstituted Complex [20]
Interacting Protein Name Protein aurora borealis (BORA) Interacting Protein Interacting Protein Info
UniProt ID
BORA_HUMAN 
Synonyms C13orf34
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-Western [21]
Interacting Protein Name Structure-specific endonuclease subunit SLX4 (SLX4) Interacting Protein Interacting Protein Info
UniProt ID
SLX4_HUMAN 
Synonyms BTBD12; FANCP; MUS312
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [10]
References  Top
REF 1 Plk1 phosphorylation of Topors is involved in its degradation. Mol Biol Rep. 2010 Jul;37(6):3023-8.
REF 2 Plk1-mediated phosphorylation of Topors regulates p53 stability. J Biol Chem. 2009 Jul 10;284(28):18588-92.
REF 3 Ubiquitylation-dependent localization of PLK1 in mitosis. Nat Cell Biol. 2013 Apr;15(4):430-9.
REF 4 CUL3 and protein kinases: insights from PLK1/KLHL22 interaction. Cell Cycle. 2013 Jul 15;12(14):2291-6.
REF 5 The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1. Mol Biol Cell. 2010 Jul 15;21(14):2500-13.
REF 6 APC/C(Cdh1)-dependent degradation of Cdc20 requires a phosphorylation on CRY-box by Polo-like kinase-1 during somatic cell cycle. Biochem Biophys Res Commun. 2013 Jun 21;436(1):12-8.
REF 7 BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells. Oncogene. 2009 Aug 6;28(31):2806-20.
REF 8 The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. Cell Signal. 2000 Jun;12(6):405-11.
REF 9 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 10 Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell. 2009 Jul 10;138(1):63-77.
REF 11 PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1;26(17):1959-71.
REF 12 The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 1998 Mar 1;12(5):706-20.
REF 13 Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells. J Biol Chem. 2005 Nov 4;280(44):36575-83.
REF 14 Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1. J Biol Chem. 2007 May 18;282(20):15217-27.
REF 15 Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem. 2003 Mar 7;278(10):8468-75.
REF 16 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491.
REF 17 HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression. Cancer Res. 2008 Sep 15;68(18):7550-60.
REF 18 Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression. Oncogene. 2004 Jan 29;23(4):865-72.
REF 19 M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex. J Biol Chem. 2003 Sep 19;278(38):35979-87.
REF 20 A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol. 2010 Jan 26;8(1):e1000287.
REF 21 Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol. 2008 Apr 7;181(1):65-78.

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