Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | Cell division cycle protein 20 homolog (CDC20) | ||||
| UniProt ID | CDC20_HUMAN | ||||
| Gene Name | CDC20 | ||||
| Gene ID | 991 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Polo-like kinase 1 (PLK1) | Target Info | PPI Info | [1] | |
| Interacting Patented-recorded Target(s) | G2/mitotic-specific cyclin B1 (CCNB1) | Target Info | PPI Info | [2] | |
| BUB1 mitotic checkpoint serine/threonine kinase (BUB1) | Target Info | PPI Info | [3] | ||
| Interacting Literature-reported Target(s) | Cyclin A2 (CCNA2) | Target Info | PPI Info | [4] | |
| S-phase kinase-associated protein 2 (SKP2) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | APC/C(Cdh1)-dependent degradation of Cdc20 requires a phosphorylation on CRY-box by Polo-like kinase-1 during somatic cell cycle. Biochem Biophys Res Commun. 2013 Jun 21;436(1):12-8. | ||||
| REF 2 | The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit. J Cell Biol. 2010 Aug 23;190(4):587-602. | ||||
| REF 3 | The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation. Nat Commun. 2016 Feb 25;7:10818. | ||||
| REF 4 | How cyclin A destruction escapes the spindle assembly checkpoint. J Cell Biol. 2010 Aug 23;190(4):501-9. | ||||
| REF 5 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
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