| References |
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The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
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| REF 2 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
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| REF 3 |
How cyclin A destruction escapes the spindle assembly checkpoint. J Cell Biol. 2010 Aug 23;190(4):501-9.
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The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators. Dev Cell. 2015 Feb 9;32(3):358-372.
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| REF 5 |
Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol Cell. 2008 May 9;30(3):290-302.
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Degradation of cyclin A is regulated by acetylation. Oncogene. 2009 Jul 23;28(29):2654-66.
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Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107. Oncogene. 2002 Nov 14;21(52):7923-32.
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| REF 9 |
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10453-8.
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A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation. Oncogene. 2012 Aug 30;31(35):3989-98.
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PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell. 1998 Dec;2(6):877-85.
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The cyclin box and C-terminus of cyclins A and E specify CDK activation and substrate specificity. Oncogene. 1997 Jan 30;14(4):491-8.
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Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest. Mol Cell Biol. 2002 May;22(9):2993-3002.
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Modulation of cell cycle control by vitamin D3 and its analogue, EB1089, in human breast cancer cells. Oncogene. 1997 Sep 25;15(13):1555-63.
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Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Eur J Biochem. 1996 Apr 15;237(2):460-7.
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p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function. Cancer Lett. 2009 Dec 28;286(2):240-9.
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Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Oncogene. 2003 Jul 10;22(28):4301-13.
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Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell. 1998 Mar;1(4):553-63.
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| REF 19 |
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
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| REF 20 |
APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint. J Biol Chem. 2014 Feb 7;289(6):3457-67.
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Differential modulation of G1-S-phase cyclin-dependent kinase 2/cyclin complexes occurs during the acquisition of a polyploid DNA content. Cell Growth Differ. 1998 Aug;9(8):639-50.
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Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3521-4.
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Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. J Biol Chem. 1996 May 31;271(22):13283-91.
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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature. 1995 Jul 27;376(6538):313-20.
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Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell. 2002 Apr;9(4):761-71.
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Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell. 2011 Jan 21;144(2):187-99.
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APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell. 2007 Aug 3;27(3):462-73.
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| REF 28 |
Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells. J Cell Biochem. 2011 Apr;112(4):1176-91.
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| REF 29 |
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol. 2006 Jan;13(1):55-62.
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Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. Mol Cell Biol. 2001 Jan;21(1):88-99.
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Modulation of Sp1 activity by a cyclin A/CDK complex. J Mol Biol. 2001 Feb 16;306(2):201-12.
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Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. EMBO J. 2001 Oct 15;20(20):5737-47.
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The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain. J Biol Chem. 2003 Nov 7;278(45):44255-64.
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| REF 34 |
Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol. 1996 Sep;16(9):4673-82.
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| REF 35 |
Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation. Mol Cell Endocrinol. 2017 Jan 5;439:1-9.
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| REF 36 |
p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell. 1995 Sep 22;82(6):915-25.
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