Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T80306 Target Info
Target Name S-phase kinase-associated protein 2 (SKP2)
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Target Type Literature-reported Target
Gene Name SKP2
UniProt ID
SKP2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [4]
Beta-transducin repeats [+] 2 Beta-transducin repeats +
Interacting Protein Name Fizzy-related protein homolog (FZR1) Interacting Protein Interacting Protein Info
UniProt ID
FZR1_HUMAN 
Synonyms CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [7]
4 Affinity Capture-Western [8]
5 Reconstituted Complex [6]
6 Reconstituted Complex [1]
Interacting Protein Name Cell division cycle protein 20 homolog (CDC20) Interacting Protein Interacting Protein Info
UniProt ID
CDC20_HUMAN 
Synonyms CDC20A; bA276H19.3; p55CDC
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [7]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name NAD-dependent deacetylase sirtuin-3 (SIRT3) Literature-reported Target Interacting Protein Info
UniProt ID
SIR3_HUMAN 
Synonyms SIR2-like protein 3; SIR2L3; Regulatory protein SIR2 homolog 3; hSIRT3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [1]
3 Reconstituted Complex [1]
Cell cycle related proteins [+] 2 Cell cycle related proteins +
Interacting Target Name Cyclin A2 (CCNA2) Literature-reported Target Interacting Protein Info
UniProt ID
CCNA2_HUMAN 
Synonyms Cyclin-A2; Cyclin-A; Cyclin A; CCNA
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [11]
3 Affinity Capture-Western [12]
4 Affinity Capture-Western [13]
5 Affinity Capture-Western [14]
6 Reconstituted Complex [15]
Interacting Protein Name Cyclin-A1 (CCNA1) Interacting Protein Interacting Protein Info
UniProt ID
CCNA1_HUMAN 
Synonyms CT146
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [16]
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-1 (CUL1) Interacting Protein Interacting Protein Info
UniProt ID
CUL1_HUMAN 
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-MS [17]
3 Affinity Capture-Western [18]
4 Affinity Capture-Western [19]
5 Affinity Capture-Western [20]
6 Affinity Capture-Western [21]
7 Affinity Capture-Western [22]
8 Affinity Capture-Western [23]
9 Affinity Capture-Western [24]
10 Affinity Capture-Western [25]
11 Affinity Capture-Western [26]
12 Affinity Capture-Western [16]
13 Affinity Capture-Western [14]
14 Affinity Capture-Western [27]
15 Affinity Capture-Western [28]
16 Affinity Capture-Western [29]
17 Affinity Capture-Western [30]
18 Affinity Capture-Western [31]
19 Affinity Capture-Western [32]
20 Affinity Capture-Western [33]
Kinases [+] 2 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [14]
4 Affinity Capture-Western [11]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [1]
7 Co-crystal Structure [34]
8 Reconstituted Complex [15]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [19]
3 Affinity Capture-Western [35]
4 Biochemical Activity [36]
5 Co-localization [19]
6 Reconstituted Complex [19]
Transcription regulators [+] 4 Transcription regulators +
Interacting Target Name Forkhead box protein O1A (FOXO1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXO1_HUMAN 
Synonyms FOXO1A; Forkhead in rhabdomyosarcoma; Forkhead box protein O1A; Forkhead box protein O1; FKHR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [38]
4 Reconstituted Complex [37]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Protein-Fragment Complementation Assay [39]
3 Reconstituted Complex [39]
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Reconstituted Complex [15]
Interacting Protein Name Forkhead box protein O3 (FOXO3) Interacting Protein Interacting Protein Info
UniProt ID
FOXO3_HUMAN 
Synonyms AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [41]
Other proteins [+] 8 Other proteins +
Interacting Protein Name S-phase kinase-associated protein 1 (SKP1) Interacting Protein Interacting Protein Info
UniProt ID
SKP1_HUMAN 
Synonyms EMC19; OCP.II; OCP2; SKP1A; TCEB1L; p19A
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [17]
2 Affinity Capture-MS [42]
3 Affinity Capture-Western [18]
4 Affinity Capture-Western [19]
5 Affinity Capture-Western [20]
6 Affinity Capture-Western [43]
7 Affinity Capture-Western [22]
8 Affinity Capture-Western [23]
9 Affinity Capture-Western [25]
10 Affinity Capture-Western [36]
11 Affinity Capture-Western [14]
12 Affinity Capture-Western [44]
13 Affinity Capture-Western [45]
14 Affinity Capture-Western [27]
15 Affinity Capture-Western [28]
16 Affinity Capture-Western [29]
17 Affinity Capture-Western [30]
18 Affinity Capture-Western [46]
19 Affinity Capture-Western [47]
20 Affinity Capture-Western [48]
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [23]
4 Affinity Capture-Western [14]
5 Affinity Capture-Western [49]
6 Affinity Capture-Western [27]
7 Affinity Capture-Western [28]
8 Affinity Capture-Western [29]
9 Biochemical Activity [50]
10 Biochemical Activity [22]
11 Biochemical Activity [51]
12 Biochemical Activity [36]
13 Biochemical Activity [16]
14 Biochemical Activity [14]
15 Biochemical Activity [7]
16 Biochemical Activity [52]
17 Biochemical Activity [53]
18 Biochemical Activity [30]
19 Biochemical Activity [54]
20 Biochemical Activity [55]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [56]
2 Affinity Capture-Western [57]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [45]
5 Biochemical Activity [58]
6 Biochemical Activity [59]
7 Biochemical Activity [45]
8 Co-localization [60]
Interacting Protein Name Cyclin-dependent kinases regulatory subunit 1 (CKS1B) Interacting Protein Interacting Protein Info
UniProt ID
CKS1_HUMAN 
Synonyms CKS1; PNAS.16; PNAS.18; ckshs1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [61]
2 Affinity Capture-Western [22]
3 Fluorescence Resonance Energy Transfer [62]
4 Reconstituted Complex [63]
5 Reconstituted Complex [52]
6 Reconstituted Complex [53]
7 Reconstituted Complex [64]
8 Reconstituted Complex [65]
Interacting Protein Name Protein BTG2 (BTG2) Interacting Protein Interacting Protein Info
UniProt ID
BTG2_HUMAN 
Synonyms PC3; TIS21
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [66]
2 Affinity Capture-Western [67]
3 Reconstituted Complex [67]
Interacting Protein Name DNA replication factor Cdt1 (CDT1) Interacting Protein Interacting Protein Info
UniProt ID
CDT1_HUMAN 
Synonyms DUP; RIS2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [68]
2 Affinity Capture-Western [31]
3 Biochemical Activity [31]
Interacting Target Name Epithelial cadherin (CDH1) Literature-reported Target Interacting Protein Info
UniProt ID
CADH1_HUMAN 
Synonyms Uvomorulin; UVO; E-cadherin gene; E-cadherin; CDHE; CD324; CAM 120/80; Cadherin-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [69]
2 Biochemical Activity [44]
Interacting Target Name CDK inhibitor 1C p57Kip2 (CDKN1C) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1C_HUMAN 
Synonyms P57KIP2; P57(KIP2); KIP2; Cyclin-dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [70]
References  Top
REF 1 Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 6;150(1):179-93.
REF 2 A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):602-6.
REF 3 The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation. J Biol Chem. 2012 Nov 30;287(49):41014-22.
REF 4 Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle. 2015;14(3):437-48.
REF 5 SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep. 2013 Aug 29;4(4):803-16.
REF 6 Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol. 2009 Apr;11(4):397-408.
REF 7 Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem. 2010 Sep 17;285(38):29128-37.
REF 8 SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis. Gastroenterology. 2009 Nov;137(5):1816-26.e1-10.
REF 9 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 10 SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol. 2012 Dec;32(24):5022-34.
REF 11 Skp2 inversely correlates with p27 and tuberin in transformed cells. Amino Acids. 2009 Jul;37(2):257-62.
REF 12 Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation. Mol Cell Endocrinol. 2017 Jan 5;439:1-9.
REF 13 Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem. 2004 Nov 19;279(47):48707-15.
REF 14 Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle. 2010 Mar 1;9(5):971-4.
REF 15 Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat Cell Biol. 1999 May;1(1):14-9.
REF 16 Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. J Biol Chem. 2006 Aug 18;281(33):24058-69.
REF 17 Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. Mol Cell Biol. 2006 Aug;26(16):5994-6004.
REF 18 PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017 Jun 22;546(7659):554-558.
REF 19 Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol. 2009 Apr;11(4):420-32.
REF 20 Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol Cell. 2012 May 11;46(3):351-61.
REF 21 Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation. J Biol Chem. 2014 Oct 10;289(41):28448-59.
REF 22 Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. EMBO J. 2008 Feb 20;27(4):679-91.
REF 23 SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol. 1999 Aug;1(4):193-9.
REF 24 Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity. Mol Biol Cell. 2011 Dec;22(24):4706-15.
REF 25 TIP120A associates with cullins and modulates ubiquitin ligase activity. J Biol Chem. 2003 May 2;278(18):15905-10.
REF 26 Substrate-mediated regulation of cullin neddylation. J Biol Chem. 2007 Jun 8;282(23):17032-40.
REF 27 Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. J Biol Chem. 2013 Nov 8;288(45):32766-76.
REF 28 Comprehensive identification of substrates for F-box proteins by differential proteomics analysis. J Proteome Res. 2012 Jun 1;11(6):3175-85.
REF 29 Ubiquitin conjugating enzyme E2 L3 promoted tumor growth of NSCLC through accelerating p27kip1 ubiquitination and degradation. Oncotarget. 2017 Aug 24;8(48):84193-84203.
REF 30 Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex. Oncogene. 2013 Jan 3;32(1):78-85.
REF 31 The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem. 2003 Aug 15;278(33):30854-8.
REF 32 Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. EMBO J. 1998 Jan 15;17(2):368-83.
REF 33 Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res. 2011 May;21(5):754-69.
REF 34 Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry. J Mol Biol. 2006 Oct 27;363(3):673-86.
REF 35 von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage. Oncogene. 2011 Jul 14;30(28):3127-38.
REF 36 Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154(3):556-68.
REF 37 Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1649-54.
REF 38 Atorvastatin prevents endothelial dysfunction in high glucose condition through Skp2-mediated degradation of FOXO1 and ICAM-1. Biochem Biophys Res Commun. 2018 Jan 8;495(2):2050-2057.
REF 39 The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell. 2003 May;11(5):1189-200.
REF 40 Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene. 2005 Nov 3;24(48):7238-47.
REF 41 Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene. 2012 Mar 22;31(12):1546-57.
REF 42 Photoactivatable protein labeling by singlet oxygen mediated reactions. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3359-3363.
REF 43 An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell. 2004 Oct 8;16(1):47-58.
REF 44 Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget. 2015 Oct 27;6(33):34953-67.
REF 45 Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem Biol. 2012 Dec 21;19(12):1515-24.
REF 46 Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination. Mol Cell Biol. 2004 Oct;24(20):8951-62.
REF 47 Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009 Jul;29(13):3529-43.
REF 48 Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment. J Cell Sci. 2013 Oct 15;126(Pt 20):4636-46.
REF 49 p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. J Biol Chem. 2004 Jun 11;279(24):25260-7.
REF 50 Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature. 2001 Sep 20;413(6853):316-22.
REF 51 Structural basis for a reciprocal regulation between SCF and CSN. Cell Rep. 2012 Sep 27;2(3):616-27.
REF 52 A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1. J Biol Chem. 2003 Aug 22;278(34):32390-6.
REF 53 A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell. 2001 Mar;7(3):639-50.
REF 54 Identification of small molecule inhibitors of p27(Kip1) ubiquitination by high-throughput screening. Cancer Sci. 2013 Nov;104(11):1461-7.
REF 55 Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. J Biol Chem. 2009 Feb 20;284(8):5265-76.
REF 56 APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell. 2007 Aug 3;27(3):462-73.
REF 57 UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. Cell. 2003 Sep 5;114(5):599-610.
REF 58 PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 2008 Sep 15;22(18):2496-506.
REF 59 Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2. J Biol Chem. 2005 Aug 26;280(34):30301-9.
REF 60 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 61 Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma. Cancer Res. 2008 Jun 1;68(11):4192-200.
REF 62 Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase. J Biol Chem. 2007 May 25;282(21):15462-70.
REF 63 The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol. 2001 Mar;3(3):321-4.
REF 64 Three different binding sites of Cks1 are required for p27-ubiquitin ligation. J Biol Chem. 2002 Nov 1;277(44):42233-40.
REF 65 High-throughput screening for inhibitors of the Cks1-Skp2 interaction. Methods Enzymol. 2005;399:717-28.
REF 66 Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1. Exp Cell Res. 2009 Nov 1;315(18):3152-62.
REF 67 Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing TrCP. Biol Pharm Bull. 2012;35(9):1539-45.
REF 68 Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J Biol Chem. 2004 Apr 23;279(17):17283-8.
REF 69 Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J Cell Physiol. 2011 Feb;226(2):407-13.
REF 70 Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10231-6.

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