| References |
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| REF 1 |
Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 6;150(1):179-93.
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| REF 2 |
A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):602-6.
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| REF 3 |
The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation. J Biol Chem. 2012 Nov 30;287(49):41014-22.
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| REF 4 |
Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle. 2015;14(3):437-48.
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| REF 5 |
SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep. 2013 Aug 29;4(4):803-16.
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| REF 6 |
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol. 2009 Apr;11(4):397-408.
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| REF 7 |
Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem. 2010 Sep 17;285(38):29128-37.
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| REF 8 |
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis. Gastroenterology. 2009 Nov;137(5):1816-26.e1-10.
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| REF 9 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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| REF 10 |
SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol. 2012 Dec;32(24):5022-34.
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| REF 11 |
Skp2 inversely correlates with p27 and tuberin in transformed cells. Amino Acids. 2009 Jul;37(2):257-62.
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| REF 12 |
Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation. Mol Cell Endocrinol. 2017 Jan 5;439:1-9.
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| REF 13 |
Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem. 2004 Nov 19;279(47):48707-15.
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| REF 14 |
Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle. 2010 Mar 1;9(5):971-4.
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| REF 15 |
Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat Cell Biol. 1999 May;1(1):14-9.
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| REF 16 |
Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. J Biol Chem. 2006 Aug 18;281(33):24058-69.
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| REF 17 |
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. Mol Cell Biol. 2006 Aug;26(16):5994-6004.
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| REF 18 |
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017 Jun 22;546(7659):554-558.
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| REF 19 |
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol. 2009 Apr;11(4):420-32.
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| REF 20 |
Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol Cell. 2012 May 11;46(3):351-61.
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| REF 21 |
Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation. J Biol Chem. 2014 Oct 10;289(41):28448-59.
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| REF 22 |
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. EMBO J. 2008 Feb 20;27(4):679-91.
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| REF 23 |
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol. 1999 Aug;1(4):193-9.
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| REF 24 |
Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity. Mol Biol Cell. 2011 Dec;22(24):4706-15.
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| REF 25 |
TIP120A associates with cullins and modulates ubiquitin ligase activity. J Biol Chem. 2003 May 2;278(18):15905-10.
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| REF 26 |
Substrate-mediated regulation of cullin neddylation. J Biol Chem. 2007 Jun 8;282(23):17032-40.
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| REF 27 |
Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. J Biol Chem. 2013 Nov 8;288(45):32766-76.
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| REF 28 |
Comprehensive identification of substrates for F-box proteins by differential proteomics analysis. J Proteome Res. 2012 Jun 1;11(6):3175-85.
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| REF 29 |
Ubiquitin conjugating enzyme E2 L3 promoted tumor growth of NSCLC through accelerating p27kip1 ubiquitination and degradation. Oncotarget. 2017 Aug 24;8(48):84193-84203.
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| REF 30 |
Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex. Oncogene. 2013 Jan 3;32(1):78-85.
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| REF 31 |
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem. 2003 Aug 15;278(33):30854-8.
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| REF 32 |
Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. EMBO J. 1998 Jan 15;17(2):368-83.
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| REF 33 |
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res. 2011 May;21(5):754-69.
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| REF 34 |
Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry. J Mol Biol. 2006 Oct 27;363(3):673-86.
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| REF 35 |
von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage. Oncogene. 2011 Jul 14;30(28):3127-38.
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| REF 36 |
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154(3):556-68.
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| REF 37 |
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1649-54.
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| REF 38 |
Atorvastatin prevents endothelial dysfunction in high glucose condition through Skp2-mediated degradation of FOXO1 and ICAM-1. Biochem Biophys Res Commun. 2018 Jan 8;495(2):2050-2057.
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| REF 39 |
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell. 2003 May;11(5):1189-200.
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| REF 40 |
Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene. 2005 Nov 3;24(48):7238-47.
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| REF 41 |
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene. 2012 Mar 22;31(12):1546-57.
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| REF 42 |
Photoactivatable protein labeling by singlet oxygen mediated reactions. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3359-3363.
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| REF 43 |
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell. 2004 Oct 8;16(1):47-58.
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| REF 44 |
Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget. 2015 Oct 27;6(33):34953-67.
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| REF 45 |
Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem Biol. 2012 Dec 21;19(12):1515-24.
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| REF 46 |
Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination. Mol Cell Biol. 2004 Oct;24(20):8951-62.
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| REF 47 |
Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009 Jul;29(13):3529-43.
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| REF 48 |
Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment. J Cell Sci. 2013 Oct 15;126(Pt 20):4636-46.
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| REF 49 |
p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. J Biol Chem. 2004 Jun 11;279(24):25260-7.
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| REF 50 |
Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature. 2001 Sep 20;413(6853):316-22.
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| REF 51 |
Structural basis for a reciprocal regulation between SCF and CSN. Cell Rep. 2012 Sep 27;2(3):616-27.
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| REF 52 |
A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1. J Biol Chem. 2003 Aug 22;278(34):32390-6.
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| REF 53 |
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell. 2001 Mar;7(3):639-50.
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| REF 54 |
Identification of small molecule inhibitors of p27(Kip1) ubiquitination by high-throughput screening. Cancer Sci. 2013 Nov;104(11):1461-7.
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| REF 55 |
Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. J Biol Chem. 2009 Feb 20;284(8):5265-76.
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| REF 56 |
APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell. 2007 Aug 3;27(3):462-73.
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| REF 57 |
UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. Cell. 2003 Sep 5;114(5):599-610.
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| REF 58 |
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 2008 Sep 15;22(18):2496-506.
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| REF 59 |
Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2. J Biol Chem. 2005 Aug 26;280(34):30301-9.
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| REF 60 |
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
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| REF 61 |
Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma. Cancer Res. 2008 Jun 1;68(11):4192-200.
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| REF 62 |
Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase. J Biol Chem. 2007 May 25;282(21):15462-70.
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| REF 63 |
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol. 2001 Mar;3(3):321-4.
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| REF 64 |
Three different binding sites of Cks1 are required for p27-ubiquitin ligation. J Biol Chem. 2002 Nov 1;277(44):42233-40.
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| REF 65 |
High-throughput screening for inhibitors of the Cks1-Skp2 interaction. Methods Enzymol. 2005;399:717-28.
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| REF 66 |
Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1. Exp Cell Res. 2009 Nov 1;315(18):3152-62.
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| REF 67 |
Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing TrCP. Biol Pharm Bull. 2012;35(9):1539-45.
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| REF 68 |
Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J Biol Chem. 2004 Apr 23;279(17):17283-8.
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| REF 69 |
Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J Cell Physiol. 2011 Feb;226(2):407-13.
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| REF 70 |
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10231-6.
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