Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | Cullin-1 (CUL1) | ||||
UniProt ID | CUL1_HUMAN | ||||
Gene Name | CUL1 | ||||
Gene ID | 8454 |
Interacting TTD Target Information | Top | ||||
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Interacting Clinical trial Target(s) | Cyclin-dependent kinase 2 (CDK2) | Target Info | PPI Info | [1] | |
Interacting Literature-reported Target(s) | M-phase inducer phosphatase 1 (MPIP1) | Target Info | PPI Info | [2] | |
Deneddylase-1 (SENP8) | Target Info | PPI Info | [3] | ||
JUN activation domain binding protein (COPS5) | Target Info | PPI Info | [4] | ||
RING-box protein 2 (RNF7) | Target Info | PPI Info | [5] | ||
Cullin-3 (CUL-3) | Target Info | PPI Info | [6] | ||
S-phase kinase-associated protein 2 (SKP2) | Target Info | PPI Info | [1] | ||
Interacting Preclinical Target(s) | Cryptochrome circadian clock 1 (CRY1) | Target Info | PPI Info | [7] |
References | Top | ||||
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REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 2 | Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44. | ||||
REF 3 | A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. Nat Cell Biol. 2010 Apr;12(4):351-61. | ||||
REF 4 | Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403. | ||||
REF 5 | NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J. 2001 Aug 1;20(15):4003-12. | ||||
REF 6 | Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65. | ||||
REF 7 | DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Elife. 2015 Mar 10;4. |
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