Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T37428 Target Info
Target Name RING-box protein 2 (RNF7)
Synonyms Sensitive to apoptosis gene protein; SAG; Regulator of cullins 2; Rbx2; ROC2; RING finger protein 7; CKII beta-binding protein 1; CKBBP1
Target Type Literature-reported Target
Gene Name RNF7
Biochemical Class Zinc-finger
UniProt ID
RBX2_HUMAN 
Target Interacting Proteins  Top
Cullins [+] 4 Cullins +
Interacting Protein Name Cullin-5 (CUL5) Interacting Protein Interacting Protein Info
UniProt ID
CUL5_HUMAN 
Synonyms VACM.1; VACM1
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Biochemical Activity [5]
6 Biochemical Activity [6]
7 Biochemical Activity [7]
8 Biochemical Activity [8]
9 Co-purification [9]
10 Reconstituted Complex [9]
11 Yeast two hybrid [10]
Interacting Protein Name Cullin-1 (CUL1) Interacting Protein Interacting Protein Info
UniProt ID
CUL1_HUMAN 
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [12]
3 Affinity Capture-Western [13]
4 Biochemical Activity [5]
5 Yeast two hybrid [10]
Interacting Protein Name Cullin-2 (CUL2) Interacting Protein Interacting Protein Info
UniProt ID
CUL2_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Yeast two hybrid [10]
Interacting Protein Name Cullin-4A (CUL4A) Interacting Protein Interacting Protein Info
UniProt ID
CUL4A_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Yeast two hybrid [10]
Ubiquitin related proteins [+] 3 Ubiquitin related proteins +
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Interacting Protein Interacting Protein Info
UniProt ID
UB2D3_HUMAN 
Synonyms E2(17)KB3; UBC4/5; UBCH5C
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [12]
3 Reconstituted Complex [7]
4 Reconstituted Complex [14]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 C (UBE2C) Interacting Protein Interacting Protein Info
UniProt ID
UBE2C_HUMAN 
Synonyms UBCH10; dJ447F3.2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [2]
3 Reconstituted Complex [8]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 S (UBE2S) Interacting Protein Interacting Protein Info
UniProt ID
UBE2S_HUMAN 
Synonyms E2.EPF; E2EPF; EPF5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [2]
3 Reconstituted Complex [8]
Other proteins [+] 1 Other proteins +
Interacting Protein Name F-box/WD repeat-containing protein 1A (BTRC) Interacting Protein Interacting Protein Info
UniProt ID
FBW1A_HUMAN 
Synonyms BETA.TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Affinity Capture-Western [2]
3 Biochemical Activity [2]
References  Top
REF 1 SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation. Oncogene. 2008 Feb 28;27(10):1404-11.
REF 2 SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate -TrCP1 via K11-linkage for degradation. Sci Rep. 2016 Dec 2;6:37441.
REF 3 SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. Oncotarget. 2014 Aug 30;5(16):6746-55.
REF 4 Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex initro. Biochem Biophys Res Commun. 2015 Jun 12;461(4):624-9.
REF 5 E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell. 2009 Feb 27;33(4):483-95.
REF 6 The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation. PLoS One. 2018 Jun 29;13(6):e0199197.
REF 7 Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates. Growth Factors. 2014 Feb;32(1):1-10.
REF 8 Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage. Clin Cancer Res. 2017 Feb 15;23(4):1104-1116.
REF 9 CBF stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Mol Cell. 2013 Feb 21;49(4):632-44.
REF 10 ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell. 1999 Apr;3(4):535-41.
REF 11 NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J. 2001 Aug 1;20(15):4003-12.
REF 12 Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. Free Radic Biol Med. 2010 Sep 15;49(6):976-83.
REF 13 SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes. DNA Cell Biol. 2001 Jul;20(7):425-34.
REF 14 SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. EMBO J. 2016 Jul 1;35(13):1400-16.

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