| References |
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| REF 1 |
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation. Oncogene. 2008 Feb 28;27(10):1404-11.
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| REF 2 |
SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate -TrCP1 via K11-linkage for degradation. Sci Rep. 2016 Dec 2;6:37441.
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| REF 3 |
SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. Oncotarget. 2014 Aug 30;5(16):6746-55.
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| REF 4 |
Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex initro. Biochem Biophys Res Commun. 2015 Jun 12;461(4):624-9.
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| REF 5 |
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell. 2009 Feb 27;33(4):483-95.
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| REF 6 |
The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation. PLoS One. 2018 Jun 29;13(6):e0199197.
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| REF 7 |
Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates. Growth Factors. 2014 Feb;32(1):1-10.
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| REF 8 |
Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage. Clin Cancer Res. 2017 Feb 15;23(4):1104-1116.
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| REF 9 |
CBF stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Mol Cell. 2013 Feb 21;49(4):632-44.
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| REF 10 |
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell. 1999 Apr;3(4):535-41.
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| REF 11 |
NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J. 2001 Aug 1;20(15):4003-12.
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| REF 12 |
Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. Free Radic Biol Med. 2010 Sep 15;49(6):976-83.
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| REF 13 |
SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes. DNA Cell Biol. 2001 Jul;20(7):425-34.
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| REF 14 |
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. EMBO J. 2016 Jul 1;35(13):1400-16.
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