| References |
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| REF 1 |
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
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| REF 2 |
Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism. Exp Cell Res. 2008 Nov 15;314(19):3453-65.
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| REF 3 |
Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. J Biol Chem. 2015 Jul 31;290(31):19208-17.
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| REF 4 |
Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPAR and RhoA/Rho-kinase. Cell Metab. 2012 Oct 3;16(4):462-72.
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| REF 5 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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| REF 6 |
Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. J Cell Biol. 2013 Oct 28;203(2):233-50.
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| REF 7 |
RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex. Genes Dev. 2004 Apr 15;18(8):856-61.
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| REF 8 |
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nat Struct Mol Biol. 2012 Apr 1;19(5):511-6, S1.
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| REF 9 |
Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol Med. 2015 Oct;7(10):1285-306.
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| REF 10 |
Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. J Biol Chem. 2002 May 3;277(18):15758-65.
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| REF 11 |
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13;46(1):67-78.
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| REF 12 |
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12365-70.
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| REF 13 |
Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. Biochem Biophys Res Commun. 2003 Apr 18;303(4):1209-16.
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| REF 14 |
Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Nat Commun. 2014 Oct 1;5:5081.
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| REF 15 |
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol. 2005 Jan;25(1):162-71.
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| REF 16 |
Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS One. 2009 Dec 21;4(12):e8391.
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| REF 17 |
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009 Oct 9;36(1):131-40.
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| REF 18 |
Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer. Science. 2014 Oct 3;346(6205):85-89.
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| REF 19 |
Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016 Sep 1;30(17):1956-70.
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| REF 20 |
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep. 2013 Mar 28;3(3):858-68.
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| REF 21 |
KLHL2 interacts with and ubiquitinates WNK kinases. Biochem Biophys Res Commun. 2013 Aug 2;437(3):457-62.
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| REF 22 |
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3. J Clin Invest. 2014 Nov;124(11):4723-36.
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| REF 23 |
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation. FEBS Lett. 2013 Jun 19;587(12):1717-22.
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| REF 24 |
A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
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| REF 25 |
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev Cell. 2007 Jun;12(6):887-900.
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| REF 26 |
An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. J Cell Sci. 2009 Apr 1;122(Pt 7):1035-44.
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| REF 27 |
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J Cell Biol. 2009 Dec 14;187(6):791-800.
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| REF 28 |
Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol Cell. 2012 Jun 29;46(6):847-58.
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| REF 29 |
K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20biquitin E3 Ligase Regulates Protein Trafficking. Mol Cell. 2014 May 22;54(4):586-600.
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| REF 30 |
KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination. Oncogene. 2015 Oct 1;34(40):5141-51.
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| REF 31 |
Involvement of selective autophagy mediated by p62/SQSTM1n KLHL3-dependent WNK4 degradation. Biochem J. 2015 Nov 15;472(1):33-41.
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| REF 32 |
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010 Jul;30(13):3275-85.
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| REF 33 |
The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells. Cell Rep. 2016 Aug 9;16(6):1629-1641.
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| REF 34 |
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 1999 Sep 15;13(18):2375-87.
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| REF 35 |
Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3503-8.
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| REF 36 |
Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
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| REF 37 |
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. J Biol Chem. 2009 Apr 24;284(17):11663-75.
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| REF 38 |
Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity. Mol Biol Cell. 2011 Dec;22(24):4706-15.
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| REF 39 |
Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis. Biochim Biophys Acta Mol Cell Res. 2017 Aug;1864(8):1405-1412.
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| REF 40 |
KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development. PLoS One. 2014 Nov 17;9(11):e112275.
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| REF 41 |
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases. Biochem J. 2017 Nov 1;474(22):3747-3761.
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| REF 42 |
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell. 2009 Sep 24;35(6):841-55.
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| REF 43 |
Suramin inhibits cullin-RING E3 ubiquitin ligases. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2011-8.
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| REF 44 |
Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo. PLoS One. 2011 Jan 13;6(1):e16071.
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| REF 45 |
TIP120A associates with cullins and modulates ubiquitin ligase activity. J Biol Chem. 2003 May 2;278(18):15905-10.
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| REF 46 |
CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Mol Cell Biol. 2006 Feb;26(4):1235-44.
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| REF 47 |
BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. J Biol Chem. 2008 Apr 25;283(17):11083-96.
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| REF 48 |
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol. 2006 Apr;8(4):348-57.
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| REF 49 |
Regulation of the CUL3biquitin Ligase by a Calcium-Dependent Co-adaptor. Cell. 2016 Oct 6;167(2):525-538.e14.
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| REF 50 |
Novel Cul3 binding proteins function to remodel E3 ligase complexes. BMC Cell Biol. 2014 Jul 10;15:28.
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| REF 51 |
The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases. Biochemistry. 2009 Apr 21;48(15):3527-37.
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| REF 52 |
Mechanism of cullin3 E3 ubiquitin ligase dimerization. PLoS One. 2012;7(7):e41350.
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| REF 53 |
BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. J Biol Chem. 2006 May 5;281(18):12664-72.
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| REF 54 |
Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
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| REF 55 |
Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Mol Biol Cell. 2012 Jul;23(13):2490-504.
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| REF 56 |
Structural Insights into KCTD Protein Assembly and Cullin3 Recognition. J Mol Biol. 2016 Jan 16;428(1):92-107.
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| REF 57 |
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling. Mol Cell. 2015 Mar 19;57(6):995-1010.
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| REF 58 |
Molecular recognition of Cullin3 by KCTDs: insights from experimental and computational investigations. Biochim Biophys Acta. 2014 Jul;1844(7):1289-98.
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| REF 59 |
CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation. J Biol Chem. 2015 May 29;290(22):13958-71.
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| REF 60 |
KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc. Cell Death Differ. 2017 Apr;24(4):649-659.
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| REF 61 |
Selective proteasomal degradation of the B' subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. J Biol Chem. 2012 Dec 21;287(52):43378-89.
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| REF 62 |
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A. Biol Open. 2012 Feb 15;1(2):82-91.
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| REF 63 |
A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
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| REF 64 |
A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system. Am J Hum Genet. 2012 Jul 13;91(1):202-8.
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| REF 65 |
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Mol Cell Biol. 2015 Jul;35(14):2385-99.
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| REF 66 |
Regulation of Cullin-RING ubiquitin ligase 1 by Spliceosome-associated protein 130 (SAP130). Biol Open. 2013 Jun 26;2(8):838-44.
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