Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T70176 Target Info
Target Name Cyclin-dependent kinase 2 (CDK2)
Synonyms Sin3 associated polypeptide; SIN3-associated protein; P33 protein kinase; Cell division protein kinase 2; CDKN2
Target Type Clinical trial Target
Gene Name CDK2
Biochemical Class Kinase
UniProt ID
CDK2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name DNA replication licensing factor MCM2 (MCM2) Interacting Protein Interacting Protein Info
UniProt ID
MCM2_HUMAN 
Synonyms BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Interacting Protein Name X-ray repair cross-complementing protein 6 (XRCC6) Interacting Protein Interacting Protein Info
UniProt ID
XRCC6_HUMAN 
Synonyms CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Biochemical Activity [4]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [6]
3 Reconstituted Complex [5]
Cell cycle related proteins [+] 7 Cell cycle related proteins +
Interacting Target Name Cyclin A2 (CCNA2) Literature-reported Target Interacting Protein Info
UniProt ID
CCNA2_HUMAN 
Synonyms Cyclin-A2; Cyclin-A; Cyclin A; CCNA
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [9]
5 Affinity Capture-MS [10]
6 Affinity Capture-MS [11]
7 Affinity Capture-Western [12]
8 Affinity Capture-Western [13]
9 Affinity Capture-Western [14]
10 Affinity Capture-Western [15]
11 Affinity Capture-Western [16]
12 Affinity Capture-Western [17]
13 Affinity Capture-Western [18]
14 Affinity Capture-Western [19]
15 Biochemical Activity [20]
16 Co-crystal Structure [21]
17 Co-crystal Structure [22]
18 Co-crystal Structure [23]
19 Co-crystal Structure [24]
20 Co-crystal Structure [25]
Interacting Target Name G1/S-specific cyclin-E1 (CCNE1) Literature-reported Target Interacting Protein Info
UniProt ID
CCNE1_HUMAN 
Synonyms G1/S-specific cyclin E; Cyclin E; CCNE
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [9]
5 Affinity Capture-MS [10]
6 Affinity Capture-MS [11]
7 Affinity Capture-Western [26]
8 Affinity Capture-Western [27]
9 Affinity Capture-Western [15]
10 Affinity Capture-Western [28]
11 Affinity Capture-Western [29]
12 Affinity Capture-Western [30]
13 Affinity Capture-Western [31]
14 Affinity Capture-Western [32]
15 Affinity Capture-Western [33]
16 Affinity Capture-Western [18]
17 Affinity Capture-Western [34]
18 Affinity Capture-Western [35]
19 Biochemical Activity [36]
20 Co-fractionation [37]
Interacting Protein Name Cyclin-A1 (CCNA1) Interacting Protein Interacting Protein Info
UniProt ID
CCNA1_HUMAN 
Synonyms CT146
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [38]
2 Affinity Capture-Western [29]
3 Affinity Capture-Western [30]
4 Affinity Capture-Western [39]
5 Biochemical Activity [40]
6 Co-crystal Structure [41]
7 Co-crystal Structure [42]
8 Co-localization [43]
9 Co-purification [44]
10 Reconstituted Complex [45]
11 Yeast two hybrid [46]
Interacting Target Name G1/S-specific cyclin-E2 (CCNE2) Literature-reported Target Interacting Protein Info
UniProt ID
CCNE2_HUMAN 
Synonyms G1/Sspecific cyclinE2
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [9]
5 Affinity Capture-MS [10]
6 Affinity Capture-MS [11]
7 Affinity Capture-Western [47]
8 Reconstituted Complex [48]
9 Yeast two hybrid [49]
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-MS [11]
3 Affinity Capture-Western [27]
4 Reconstituted Complex [27]
Interacting Protein Name Cyclin-H (CCNH) Interacting Protein Interacting Protein Info
UniProt ID
CCNH_HUMAN 
Synonyms CAK; CycH; p34; p37
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [8]
3 Affinity Capture-MS [9]
4 Biochemical Activity [27]
Interacting Target Name Cyclin D (CCND3) Literature-reported Target Interacting Protein Info
UniProt ID
CCND3_HUMAN 
Synonyms G1/S-specific cyclin-D3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [50]
Cell division cycle proteins [+] 3 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Biochemical Activity [52]
3 Biochemical Activity [53]
4 Biochemical Activity [54]
5 Biochemical Activity [27]
6 Biochemical Activity [55]
7 Biochemical Activity [56]
8 Biochemical Activity [57]
9 Biochemical Activity [58]
10 Biochemical Activity [59]
11 Biochemical Activity [60]
12 Biochemical Activity [30]
13 Biochemical Activity [39]
14 Biochemical Activity [42]
15 Biochemical Activity [61]
16 Biochemical Activity [36]
17 Biochemical Activity [62]
18 Biochemical Activity [63]
19 Biochemical Activity [64]
20 Biochemical Activity [65]
Interacting Protein Name Retinoblastoma-like protein 1 (RBL1) Interacting Protein Interacting Protein Info
UniProt ID
RBL1_HUMAN 
Synonyms CP107; PRB1; p107
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [10]
5 Affinity Capture-MS [11]
6 Biochemical Activity [66]
7 Biochemical Activity [67]
8 Protein-peptide [32]
Interacting Protein Name Retinoblastoma-like protein 2 (RBL2) Interacting Protein Interacting Protein Info
UniProt ID
RBL2_HUMAN 
Synonyms P130; Rb2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [10]
5 Affinity Capture-MS [11]
6 Biochemical Activity [67]
7 Protein-peptide [32]
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-1 (CUL1) Interacting Protein Interacting Protein Info
UniProt ID
CUL1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [8]
3 Affinity Capture-Western [38]
Ester hydrolases [+] 4 Ester hydrolases +
Interacting Protein Name Cyclin-dependent kinase inhibitor 3 (CDKN3) Interacting Protein Interacting Protein Info
UniProt ID
CDKN3_HUMAN 
Synonyms CDI1; CIP2; KAP; KAP1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [8]
4 Yeast two hybrid [68]
5 Yeast two hybrid [69]
Interacting Target Name M-phase inducer phosphatase 2 (MPIP2) Clinical trial Target Interacting Protein Info
UniProt ID
MPIP2_HUMAN 
Synonyms Dual specificity phosphatase Cdc25B; CDC25HU2; Cdc25B phosphatase
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [70]
2 Yeast two hybrid [71]
Interacting Target Name Serine/threonine PP2A-alpha (PPP2CA) Clinical trial Target Interacting Protein Info
UniProt ID
PP2AA_HUMAN 
Synonyms Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; RP-C; Replication protein C; PP2A-alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [72]
2 Co-purification [72]
Interacting Target Name M-phase inducer phosphatase 1 (MPIP1) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP1_HUMAN 
Synonyms Dual specificity phosphatase Cdc25A; Cdc25A phosphatase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [73]
2 Reconstituted Complex [74]
Histones [+] 2 Histones +
Interacting Protein Name Histone H1.1 (HIST1H1A) Interacting Protein Interacting Protein Info
UniProt ID
H11_HUMAN 
Synonyms H1.1; H1A; H1F1; HIST1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [75]
2 Affinity Capture-Western [76]
3 Affinity Capture-Western [77]
4 Biochemical Activity [78]
5 Biochemical Activity [53]
6 Biochemical Activity [79]
7 Biochemical Activity [14]
8 Biochemical Activity [27]
9 Biochemical Activity [15]
10 Biochemical Activity [55]
11 Biochemical Activity [44]
12 Biochemical Activity [80]
13 Biochemical Activity [81]
14 Biochemical Activity [56]
15 Biochemical Activity [28]
16 Biochemical Activity [82]
17 Biochemical Activity [83]
18 Biochemical Activity [84]
19 Biochemical Activity [85]
20 Biochemical Activity [76]
Interacting Protein Name Histone H1.0 (H1F0) Interacting Protein Interacting Protein Info
UniProt ID
H10_HUMAN 
Synonyms H10; H1FV
Evidence Score (E-score) 10 Experimental Evidences +
1 Biochemical Activity [86]
2 Biochemical Activity [87]
3 Biochemical Activity [16]
4 Biochemical Activity [30]
5 Biochemical Activity [88]
6 Biochemical Activity [64]
7 Biochemical Activity [89]
8 Biochemical Activity [90]
9 Biochemical Activity [91]
10 Biochemical Activity [92]
Kinases [+] 3 Kinases +
Interacting Target Name Cyclin-dependent kinase 7 (CDK7) Clinical trial Target Interacting Protein Info
UniProt ID
CDK7_HUMAN 
Synonyms TFIIH basal transcription factor complex kinase subunit; Serine/threonine-protein kinase 1; P39 Mo15; MO15; Cell division protein kinase 7; CDKN7; CDK-activating kinase 1; CDK-activating kinase; CAK1; CAK; 39 kDa protein kinase
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [93]
4 Biochemical Activity [94]
5 Biochemical Activity [27]
Interacting Target Name CDC7-related kinase (CDC7) Clinical trial Target Interacting Protein Info
UniProt ID
CDC7_HUMAN 
Synonyms huCdc7; HsCdc7; Cell division cycle 7-related protein kinase; Cell division cycle 7related protein kinase; CDC7related kinase; CDC7L1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [95]
2 Biochemical Activity [95]
3 Biochemical Activity [96]
Interacting Target Name Cyclin-dependent kinase 6 (CDK6) Successful Target Interacting Protein Info
UniProt ID
CDK6_HUMAN 
Synonyms Serine/threonine-protein kinase PLSTIRE; Serine/threonine protein kinase PLSTIRE; Cell division protein kinase 6; CDKN6
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [43]
2 Co-purification [72]
Lyases [+] 1 Lyases +
Interacting Protein Name Fructose-bisphosphate aldolase A (ALDOA) Interacting Protein Interacting Protein Info
UniProt ID
ALDOA_HUMAN 
Synonyms ALDA; GSD12; HEL.S.87p
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [97]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Target Name G2/mitotic-specific cyclin B1 (CCNB1) Patented-recorded Target Interacting Protein Info
UniProt ID
CCNB1_HUMAN 
Synonyms G2/mitotic-specific cyclin-B1; Cyclin B1; CCNB
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [9]
5 Affinity Capture-MS [10]
6 Affinity Capture-MS [11]
7 Reconstituted Complex [98]
8 Reconstituted Complex [45]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [99]
2 Affinity Capture-Western [100]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [101]
2 Biochemical Activity [102]
3 Co-localization [43]
Transcription regulators [+] 4 Transcription regulators +
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [63]
2 Biochemical Activity [103]
3 Biochemical Activity [63]
Interacting Protein Name Transcription factor Dp-1 (TFDP1) Interacting Protein Interacting Protein Info
UniProt ID
TFDP1_HUMAN 
Synonyms DP1; DRTF1; Dp.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [63]
3 Biochemical Activity [63]
Interacting Target Name Forkhead box protein M1 (FOXM1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXM1_HUMAN 
Synonyms Winged-helix factor from INS-1 cells; Winged helix factor from INS-1 cells; WIN; Transcription factor Trident; MPP2; MPM-2 reactive phosphoprotein 2; M-phase phosphoprotein 2; HNF-3/fork-head homolog-11; HNF-3/fork-head homolog 11; HFH-11; HFH11; Hepatocyte nuclear factor 3 forkhead homolog 11; Foxm1b; Foxm1; Forkhead-related protein FKHL16; Forkhead Box (Fox) m1b; FKHL16
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [104]
2 Biochemical Activity [105]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [52]
2 Co-localization [43]
Other proteins [+] 8 Other proteins +
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [8]
3 Affinity Capture-MS [9]
4 Affinity Capture-MS [10]
5 Affinity Capture-MS [11]
6 Affinity Capture-Western [84]
7 Affinity Capture-Western [106]
8 Affinity Capture-Western [14]
9 Affinity Capture-Western [30]
10 Affinity Capture-Western [83]
11 Affinity Capture-Western [107]
12 Affinity Capture-Western [17]
13 Affinity Capture-Western [18]
14 Affinity Capture-Western [34]
15 Affinity Capture-Western [108]
16 Affinity Capture-Western [109]
17 Affinity Capture-Western [110]
18 Affinity Capture-Western [88]
19 Affinity Capture-Western [111]
20 Affinity Capture-Western [112]
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [9]
5 Affinity Capture-MS [10]
6 Affinity Capture-MS [11]
7 Affinity Capture-Western [26]
8 Affinity Capture-Western [106]
9 Affinity Capture-Western [14]
10 Affinity Capture-Western [15]
11 Affinity Capture-Western [113]
12 Affinity Capture-Western [30]
13 Affinity Capture-Western [83]
14 Affinity Capture-Western [107]
15 Affinity Capture-Western [114]
16 Affinity Capture-Western [17]
17 Affinity Capture-Western [18]
18 Affinity Capture-Western [108]
19 Affinity Capture-Western [110]
20 Affinity Capture-Western [115]
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [9]
5 Affinity Capture-MS [10]
6 Affinity Capture-MS [11]
7 Affinity Capture-Western [116]
8 Affinity Capture-Western [38]
9 Affinity Capture-Western [109]
10 Co-crystal Structure [117]
11 Reconstituted Complex [116]
Interacting Protein Name Cyclin-dependent kinases regulatory subunit 1 (CKS1B) Interacting Protein Interacting Protein Info
UniProt ID
CKS1_HUMAN 
Synonyms CKS1; PNAS.16; PNAS.18; ckshs1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [9]
4 Affinity Capture-MS [10]
5 Affinity Capture-MS [11]
6 Co-crystal Structure [118]
7 Co-crystal Structure [117]
8 Co-fractionation [97]
Interacting Protein Name S-phase kinase-associated protein 1 (SKP1) Interacting Protein Interacting Protein Info
UniProt ID
SKP1_HUMAN 
Synonyms EMC19; OCP.II; OCP2; SKP1A; TCEB1L; p19A
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [10]
4 Affinity Capture-Western [38]
5 Co-crystal Structure [117]
6 Reconstituted Complex [116]
Interacting Target Name Proliferating cell nuclear antigen (PCNA) Clinical trial Target Interacting Protein Info
UniProt ID
PCNA_HUMAN 
Synonyms Cyclin
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [119]
4 Affinity Capture-Western [120]
5 Biochemical Activity [62]
Interacting Protein Name DNA replication factor Cdt1 (CDT1) Interacting Protein Interacting Protein Info
UniProt ID
CDT1_HUMAN 
Synonyms DUP; RIS2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Biochemical Activity [121]
Interacting Protein Name Origin recognition complex subunit 2 (ORC2) Interacting Protein Interacting Protein Info
UniProt ID
ORC2_HUMAN 
Synonyms ORC2L
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [122]
2 Reconstituted Complex [48]
References  Top
REF 1 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Stem Cells. 2011 Apr;29(4):651-9.
REF 2 Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases. J Biol Chem. 2006 Apr 14;281(15):10281-90.
REF 3 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 4 Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. J Biol Chem. 2004 Aug 6;279(32):33727-41.
REF 5 BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Mol Cell Biol. 1999 Jul;19(7):4843-54.
REF 6 BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res. 1996 Jul 15;56(14):3168-72.
REF 7 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 8 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 9 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 10 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 11 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 12 The transcriptional co-activator PCAF regulates cdk2 activity. Nucleic Acids Res. 2009 Nov;37(21):7072-84.
REF 13 APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint. J Biol Chem. 2014 Feb 7;289(6):3457-67.
REF 14 Modulation of cell cycle control by vitamin D3 and its analogue, EB1089, in human breast cancer cells. Oncogene. 1997 Sep 25;15(13):1555-63.
REF 15 p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function. Cancer Lett. 2009 Dec 28;286(2):240-9.
REF 16 Autocatalytic phosphorylation of CDK2 at the activating Thr160. Cell Cycle. 2007 Apr 1;6(7):843-52.
REF 17 cAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA. Mol Biol Cell. 2005 Mar;16(3):1527-42.
REF 18 ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cyc... J Biol Chem. 2005 Feb 4;280(5):3185-96.
REF 19 Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation. Genes Dev. 2011 Apr 15;25(8):845-62.
REF 20 Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities. J Biol Chem. 1993 Sep 25;268(27):20443-51.
REF 21 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding. J Med Chem. 2004 Jun 17;47(13):3367-80.
REF 22 Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3079-82.
REF 23 Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate. Structure. 2001 May 9;9(5):389-97.
REF 24 Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism. Biochemistry. 2002 Jun 11;41(23):7301-11.
REF 25 3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors. Bioorg Med Chem Lett. 2006 Feb 15;16(4):1084-90.
REF 26 p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell. 2007 Jan 26;128(2):281-94.
REF 27 Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Eur J Biochem. 1996 Apr 15;237(2):460-7.
REF 28 Inducible expression of cyclin D1 in T-47D human breast cancer cells is sufficient for Cdk2 activation and pRB hyperphosphorylation. J Cell Biochem. 1996 Mar 1;60(3):363-78.
REF 29 Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells. J Biol Chem. 2004 Mar 26;279(13):12695-705.
REF 30 CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes. Eur J Cell Biol. 2003 May;82(5):253-61.
REF 31 HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression. Mol Cancer. 2010 Nov 23;9:302.
REF 32 Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 1998 Feb 15;12(4):456-61.
REF 33 CDK2 phosphorylation regulates the protein stability of KLF10 by interfering with binding of the E3 ligase SIAH1. Biochim Biophys Acta. 2015 May;1853(5):1174-81.
REF 34 p53-independent induction of G1 arrest and p21WAF1/CIP1 expression by ascofuranone, an isoprenoid antibiotic, through downregulation of c-Myc. Mol Cancer Ther. 2010 Jul;9(7):2102-13.
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