Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | Cyclin-dependent kinase 6 (CDK6) | Successful | Target Info | ||
UniProt ID | CDK6_HUMAN | ||||
Gene Name | CDK6 | ||||
Gene ID | 1021 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Cyclin-dependent kinase 6 (CDK6) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | Cyclin-dependent kinase 2 (CDK2) | Target Info | PPI Info | [2] | |
G1/S-specific cyclin-D1 (CCND1) | Target Info | PPI Info | [3] | ||
Interacting Literature-reported Target(s) | CDK inhibitor 1B p27Kip1 (CDKN1B) | Target Info | PPI Info | [4] | |
CDK inhibitor 4C p18-INK4c (CDKN2C) | Target Info | PPI Info | [5] | ||
Cyclin D (CCND3) | Target Info | PPI Info | [6] | ||
Melanoma differentiation-associated protein 6 (CDKN1A) | Target Info | PPI Info | [4] | ||
Multiple tumor suppressor 1 (CDKN2A) | Target Info | PPI Info | [7] |
References | Top | ||||
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REF 1 | The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20. | ||||
REF 2 | Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms. J Biol Chem. 2000 Nov 3;275(44):34744-9. | ||||
REF 3 | Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90. | ||||
REF 4 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 5 | Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 1994 Dec 15;8(24):2939-52. | ||||
REF 6 | Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol Cell Biol. 2006 Jul;26(13):5070-85. | ||||
REF 7 | Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A. Curr Biol. 1996 Jan 1;6(1):84-91. |
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