| References |
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| REF 1 |
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature. 2010 Mar 25;464(7288):624-7.
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| REF 2 |
TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Nat Cell Biol. 2012 May 6;14(6):625-33.
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| REF 3 |
Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF. Oncogene. 2015 Mar 26;34(13):1688-97.
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| REF 4 |
GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF. Oncotarget. 2017 Mar 7;8(10):16293-16302.
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| REF 5 |
NMI mediates transcription-independent ARF regulation in response to cellular stresses. Mol Biol Cell. 2012 Dec;23(23):4635-46.
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| REF 6 |
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell. 2005 Jul 1;121(7):1071-83.
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| REF 7 |
OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
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| REF 8 |
The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner. Biochemistry. 2004 Apr 13;43(14):4394-9.
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| REF 9 |
Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb. Biochemistry. 2002 Mar 26;41(12):3977-83.
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| REF 10 |
PCAF acts as a gastric cancer suppressor through a novel PCAF-p16-CDK4 axis. Am J Cancer Res. 2016 Dec 1;6(12):2772-2786.
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| REF 11 |
Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). Genes Dev. 1999 Nov 15;13(22):3027-33.
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| REF 12 |
ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem. 2009 Jan 30;284(5):2803-10.
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| REF 13 |
Proteomic analysis of p16ink4a-binding proteins. Proteomics. 2007 Nov;7(22):4102-11.
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| REF 14 |
Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes. Oncogene. 2004 Oct 21;23(49):8097-104.
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| REF 15 |
Delineation of the domains required for physical and functional interaction of p14ARF with human topoisomerase I. Oncogene. 2003 Apr 3;22(13):1945-54.
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| REF 16 |
Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes. Exp Cell Res. 1999 Dec 15;253(2):561-72.
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| REF 17 |
Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A. Curr Biol. 1996 Jan 1;6(1):84-91.
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| REF 18 |
Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90.
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| REF 19 |
Biologic and biochemical analyses of p16(INK4a) mutations from primary tumors. J Natl Cancer Inst. 1999 Sep 15;91(18):1569-74.
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| REF 20 |
A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6. Cancer Res. 2007 Oct 1;67(19):9134-41.
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| REF 21 |
CDKN2A and CDK4 mutation analysis in Italian melanoma-prone families: functional characterization of a novel CDKN2A germ line mutation. Br J Cancer. 2001 Sep 14;85(6):836-44.
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| REF 22 |
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. 1998 Mar 20;92(6):725-34.
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| REF 23 |
Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10699-704.
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| REF 24 |
Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. J Biol Chem. 2003 Feb 14;278(7):4981-9.
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| REF 25 |
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription. J Biol Chem. 2001 Jul 27;276(30):28421-9.
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| REF 26 |
Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):978-83.
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| REF 27 |
ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress. FEBS Lett. 2010 Sep 24;584(18):3909-15.
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| REF 28 |
ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis. J Mol Cell Biol. 2015 Apr;7(2):154-67.
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| REF 29 |
Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2. Oncogene. 2002 Jul 4;21(29):4498-507.
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| REF 30 |
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol. 2003 Dec;23(23):8902-12.
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| REF 31 |
p14(ARF) inhibits the functions of adenovirus E1A oncoprotein. Biochem J. 2011 Mar 1;434(2):275-85.
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| REF 32 |
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma. Clin Cancer Res. 2010 Jun 1;16(11):2949-58.
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| REF 33 |
A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. Biochem J. 2006 Jan 15;393(Pt 2):489-501.
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| REF 34 |
MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal. Mol Cancer Res. 2007 Apr;5(4):403-12.
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| REF 35 |
p14ARF is capable of promoting HIV-1 tat degradation. Cell Cycle. 2008 May 15;7(10):1433-9.
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| REF 36 |
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8292-7.
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| REF 37 |
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J. 1998 Sep 1;17(17):5001-14.
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| REF 38 |
Hypophosphorylation of Mdm2 augments p53 stability. Mol Cell Biol. 2002 Sep;22(17):6170-82.
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| REF 39 |
Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library. Sci Adv. 2017 Oct 18;3(10):e1701383.
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| REF 40 |
p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase. J Biol Chem. 2004 Nov 26;279(48):50157-66.
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| REF 41 |
Peptides derived from two dynamically disordered proteins self-assemble into amyloid-like fibrils. J Am Chem Soc. 2003 Mar 19;125(11):3200-1.
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| REF 42 |
Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization. Oncogene. 2000 Jun 15;19(26):2978-85.
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| REF 43 |
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol Cell. 2003 Nov;12(5):1151-64.
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| REF 44 |
Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability. J Biol Chem. 2006 Jul 7;281(27):18463-72.
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| REF 45 |
The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis. J Cell Biol. 2010 Mar 22;188(6):905-18.
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| REF 46 |
Identification of a novel nucleophosmin-interaction motif in the tumor suppressor p14arf. FEBS J. 2018 Mar;285(5):832-847.
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| REF 47 |
Proteomic dissection of the von Hippel-Lindau (VHL) interactome. J Proteome Res. 2011 Nov 4;10(11):5175-82.
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| REF 48 |
Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6459-63.
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| REF 49 |
Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein. Sci Rep. 2015 Jul 27;5:12605.
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