Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T45755 Target Info
Target Name CDK inhibitor 4C p18-INK4c (CDKN2C)
Synonyms P18-INK6; P18-INK4c; P18(INK4c) protein; P18(INK4c); P18 INK4c protein; Cyclin-dependent kinase 6 inhibitor; Cyclin-dependent kinase 4 inhibitor C
Target Type Literature-reported Target
Gene Name CDKN2C
UniProt ID
CDN2C_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 2 Kinases +
Interacting Target Name Cyclin-dependent kinase 6 (CDK6) Successful Target Interacting Protein Info
UniProt ID
CDK6_HUMAN 
Synonyms Serine/threonine-protein kinase PLSTIRE; Serine/threonine protein kinase PLSTIRE; Cell division protein kinase 6; CDKN6
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Fluorescence Resonance Energy Transfer [4]
5 Reconstituted Complex [3]
6 Yeast two hybrid [3]
7 Yeast two hybrid [5]
8 Yeast two hybrid [6]
Interacting Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target Interacting Protein Info
UniProt ID
CDK4_HUMAN 
Synonyms PSK-J3; Cell division protein kinase 4
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Fluorescence Resonance Energy Transfer [4]
5 Reconstituted Complex [3]
6 Yeast two hybrid [3]
7 Yeast two hybrid [6]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 3 Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 1994 Dec 15;8(24):2939-52.
REF 4 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 5 Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015 Apr 23;161(3):647-660.
REF 6 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.

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