Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T14006 Target Info
Target Name CDK inhibitor 1B p27Kip1 (CDKN1B)
Synonyms p27Kip1; KIP1; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Target Type Literature-reported Target
Gene Name CDKN1B
UniProt ID
CDN1B_HUMAN 
Target Interacting Proteins  Top
Cell cycle related proteins [+] 4 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-E1 (CCNE1) Literature-reported Target Interacting Protein Info
UniProt ID
CCNE1_HUMAN 
Synonyms G1/S-specific cyclin E; Cyclin E; CCNE
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Reconstituted Complex [6]
Interacting Target Name Cyclin D (CCND3) Literature-reported Target Interacting Protein Info
UniProt ID
CCND3_HUMAN 
Synonyms G1/S-specific cyclin-D3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [10]
5 Affinity Capture-Western [11]
6 Reconstituted Complex [8]
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [8]
3 Reconstituted Complex [6]
Interacting Target Name Cyclin A2 (CCNA2) Literature-reported Target Interacting Protein Info
UniProt ID
CCNA2_HUMAN 
Synonyms Cyclin-A2; Cyclin-A; Cyclin A; CCNA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [12]
3 Reconstituted Complex [13]
Kinases [+] 6 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 19 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [14]
3 Affinity Capture-Western [6]
4 Affinity Capture-Western [15]
5 Affinity Capture-Western [16]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [2]
8 Affinity Capture-Western [17]
9 Affinity Capture-Western [3]
10 Affinity Capture-Western [18]
11 Affinity Capture-Western [5]
12 Affinity Capture-Western [19]
13 Affinity Capture-Western [20]
14 Affinity Capture-Western [21]
15 Affinity Capture-Western [22]
16 Reconstituted Complex [12]
17 Reconstituted Complex [6]
18 Reconstituted Complex [13]
19 Reconstituted Complex [23]
Interacting Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target Interacting Protein Info
UniProt ID
CDK4_HUMAN 
Synonyms PSK-J3; Cell division protein kinase 4
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [15]
3 Affinity Capture-Western [16]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [18]
6 Affinity Capture-Western [20]
7 Affinity Capture-Western [22]
8 Reconstituted Complex [8]
9 Reconstituted Complex [6]
Interacting Target Name Cyclin-dependent kinase 6 (CDK6) Successful Target Interacting Protein Info
UniProt ID
CDK6_HUMAN 
Synonyms Serine/threonine-protein kinase PLSTIRE; Serine/threonine protein kinase PLSTIRE; Cell division protein kinase 6; CDKN6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-Western [25]
3 Co-localization [26]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Biochemical Activity [28]
3 Co-localization [26]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-Western [25]
Interacting Target Name Cyclin-dependent kinase 5 (CDK5) Patented-recorded Target Interacting Protein Info
UniProt ID
CDK5_HUMAN 
Synonyms TPKII catalytic subunit; Tau protein kinase II catalytic subunit; Serine/threonine-protein kinase PSSALRE; Serine/threonine protein kinase PSSALRE; Proline-directed protein kinase F(A) (PDPK F(A)); Proline-directed protein kinase 33 kDa subunit; PDPK; Cyclin-dependent-like kinase 5; Cyclin-dependent kinase 5 (CDK5); Cell division protein kinase 5; CDKN5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Biochemical Activity [29]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Target Name Exportin-1 (XPO1) Clinical trial Target Interacting Protein Info
UniProt ID
XPO1_HUMAN 
Synonyms Exp1; CRM1; Chromosome region maintenance 1 protein homolog
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [5]
4 Reconstituted Complex [2]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Affinity Capture-Western [27]
3 Affinity Capture-Western [20]
4 Affinity Capture-Western [32]
5 Affinity Capture-Western [33]
6 Affinity Capture-Western [34]
7 Reconstituted Complex [31]
Other proteins [+] 1 Other proteins +
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Affinity Capture-Western [19]
3 Affinity Capture-Western [21]
4 Affinity Capture-Western [35]
5 Affinity Capture-Western [36]
6 Affinity Capture-Western [37]
7 Affinity Capture-Western [38]
8 Affinity Capture-Western [39]
9 Affinity Capture-Western [40]
10 Protein-peptide [41]
References  Top
REF 1 Cyclin E/Cdk2 activity is controlled by different mechanisms in the G0 and G1 phases of the cell cycle. Cell Growth Differ. 1996 Oct;7(10):1283-90.
REF 2 CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol Biol Cell. 2003 Jan;14(1):201-13.
REF 3 p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell. 2007 Jan 26;128(2):281-94.
REF 4 Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 1997 Sep 1;16(17):5334-44.
REF 5 Modification of p27 with O-linked N-acetylglucosamine regulates cell proliferation in hepatocellular carcinoma. Mol Carcinog. 2017 Jan;56(1):258-271.
REF 6 Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest. Mol Cell Biol. 2002 May;22(9):2993-3002.
REF 7 Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. J Proteome Res. 2013 Jul 5;12(7):3181-92.
REF 8 Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence. Oncogene. 2001 Apr 12;20(16):2000-9.
REF 9 Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol Cell Biol. 2006 Jul;26(13):5070-85.
REF 10 Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells. Oncogene. 1999 Nov 4;18(46):6388-97.
REF 11 Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis. Endocrinology. 1999 Jun;140(6):2790-800.
REF 12 Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10453-8.
REF 13 Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell. 2007 Jan 26;128(2):269-80.
REF 14 Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell. 1998 Mar;1(4):553-63.
REF 15 Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 1996 Dec 2;15(23):6595-604.
REF 16 C-terminal phosphorylation controls the stability and function of p27kip1. EMBO J. 2006 Nov 1;25(21):5159-70.
REF 17 CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes. Eur J Cell Biol. 2003 May;82(5):253-61.
REF 18 Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells. J Biol Chem. 2006 Feb 10;281(6):3711-21.
REF 19 Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem. 2004 Nov 19;279(47):48707-15.
REF 20 Jun activation domain-binding protein 1 negatively regulate p27 kip1 in non-Hodgkin's lymphomas. Cancer Biol Ther. 2008 Mar;7(3):460-7.
REF 21 SUMOylation regulates p27Kip1 stability and localization in response to TGF. J Mol Cell Biol. 2016 Feb;8(1):17-30.
REF 22 Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines. Exp Cell Res. 2011 Jun 10;317(10):1476-89.
REF 23 Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division. J Mol Biol. 2005 Jun 17;349(4):764-73.
REF 24 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 25 S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines. J Cell Physiol. 2008 Nov;217(2):558-68.
REF 26 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 27 COPS5 inhibition arrests the proliferation and growth of serous ovarian cancer cells via the elevation of p27 level. Biochem Biophys Res Commun. 2017 Nov 4;493(1):85-93.
REF 28 Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem. 2002 Aug 9;277(32):28706-13.
REF 29 Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity. J Biol Chem. 2013 May 3;288(18):12615-26.
REF 30 Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem. 2002 Apr 26;277(17):14355-8.
REF 31 Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma. Cancer Res. 2006 Sep 1;66(17):8581-9.
REF 32 Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. Oncogene. 2004 Nov 25;23(55):8868-75.
REF 33 Rare sugar D-allose induces specific up-regulation of TXNIP and subsequent G1 cell cycle arrest in hepatocellular carcinoma cells by stabilization of p27kip1. Int J Oncol. 2008 Feb;32(2):377-85.
REF 34 JAB1 and phospho-Ser10 p27 expression profile determine human hepatocellular carcinoma prognosis. J Cancer Res Clin Oncol. 2014 Jun;140(6):969-78.
REF 35 Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins. Oncogene. 2005 Apr 7;24(15):2483-94.
REF 36 An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell. 2004 Oct 8;16(1):47-58.
REF 37 Damage-specific DNA binding protein 1 (DDB1) is involved in ubiquitin-mediated proteolysis of p27Kip1 in response to UV irradiation. Biochimie. 2011 May;93(5):867-75.
REF 38 Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2. Cell Cycle. 2010 Mar 1;9(5):975-9.
REF 39 Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. EMBO J. 2008 Feb 20;27(4):679-91.
REF 40 Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian and breast cancer. Int J Mol Med. 2011 Jul;28(1):109-14.
REF 41 SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol. 1999 Aug;1(4):193-9.

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