| References |
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| REF 1 |
Cyclin E/Cdk2 activity is controlled by different mechanisms in the G0 and G1 phases of the cell cycle. Cell Growth Differ. 1996 Oct;7(10):1283-90.
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| REF 2 |
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol Biol Cell. 2003 Jan;14(1):201-13.
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| REF 3 |
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell. 2007 Jan 26;128(2):281-94.
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| REF 4 |
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 1997 Sep 1;16(17):5334-44.
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Modification of p27 with O-linked N-acetylglucosamine regulates cell proliferation in hepatocellular carcinoma. Mol Carcinog. 2017 Jan;56(1):258-271.
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| REF 6 |
Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest. Mol Cell Biol. 2002 May;22(9):2993-3002.
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Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. J Proteome Res. 2013 Jul 5;12(7):3181-92.
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| REF 8 |
Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence. Oncogene. 2001 Apr 12;20(16):2000-9.
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| REF 9 |
Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol Cell Biol. 2006 Jul;26(13):5070-85.
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| REF 10 |
Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells. Oncogene. 1999 Nov 4;18(46):6388-97.
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| REF 11 |
Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis. Endocrinology. 1999 Jun;140(6):2790-800.
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| REF 12 |
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10453-8.
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| REF 13 |
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell. 2007 Jan 26;128(2):269-80.
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| REF 14 |
Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell. 1998 Mar;1(4):553-63.
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| REF 15 |
Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 1996 Dec 2;15(23):6595-604.
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| REF 16 |
C-terminal phosphorylation controls the stability and function of p27kip1. EMBO J. 2006 Nov 1;25(21):5159-70.
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| REF 17 |
CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes. Eur J Cell Biol. 2003 May;82(5):253-61.
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| REF 18 |
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells. J Biol Chem. 2006 Feb 10;281(6):3711-21.
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| REF 19 |
Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem. 2004 Nov 19;279(47):48707-15.
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| REF 20 |
Jun activation domain-binding protein 1 negatively regulate p27 kip1 in non-Hodgkin's lymphomas. Cancer Biol Ther. 2008 Mar;7(3):460-7.
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| REF 21 |
SUMOylation regulates p27Kip1 stability and localization in response to TGF. J Mol Cell Biol. 2016 Feb;8(1):17-30.
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| REF 22 |
Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines. Exp Cell Res. 2011 Jun 10;317(10):1476-89.
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| REF 23 |
Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division. J Mol Biol. 2005 Jun 17;349(4):764-73.
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| REF 24 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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| REF 25 |
S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines. J Cell Physiol. 2008 Nov;217(2):558-68.
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| REF 26 |
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
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| REF 27 |
COPS5 inhibition arrests the proliferation and growth of serous ovarian cancer cells via the elevation of p27 level. Biochem Biophys Res Commun. 2017 Nov 4;493(1):85-93.
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| REF 28 |
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem. 2002 Aug 9;277(32):28706-13.
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| REF 29 |
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity. J Biol Chem. 2013 May 3;288(18):12615-26.
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| REF 30 |
Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem. 2002 Apr 26;277(17):14355-8.
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| REF 31 |
Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma. Cancer Res. 2006 Sep 1;66(17):8581-9.
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| REF 32 |
Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. Oncogene. 2004 Nov 25;23(55):8868-75.
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| REF 33 |
Rare sugar D-allose induces specific up-regulation of TXNIP and subsequent G1 cell cycle arrest in hepatocellular carcinoma cells by stabilization of p27kip1. Int J Oncol. 2008 Feb;32(2):377-85.
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| REF 34 |
JAB1 and phospho-Ser10 p27 expression profile determine human hepatocellular carcinoma prognosis. J Cancer Res Clin Oncol. 2014 Jun;140(6):969-78.
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| REF 35 |
Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins. Oncogene. 2005 Apr 7;24(15):2483-94.
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| REF 36 |
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell. 2004 Oct 8;16(1):47-58.
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| REF 37 |
Damage-specific DNA binding protein 1 (DDB1) is involved in ubiquitin-mediated proteolysis of p27Kip1 in response to UV irradiation. Biochimie. 2011 May;93(5):867-75.
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| REF 38 |
Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2. Cell Cycle. 2010 Mar 1;9(5):975-9.
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| REF 39 |
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. EMBO J. 2008 Feb 20;27(4):679-91.
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| REF 40 |
Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian and breast cancer. Int J Mol Med. 2011 Jul;28(1):109-14.
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| REF 41 |
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol. 1999 Aug;1(4):193-9.
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