Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T39855 Target Info
Target Name Melanoma differentiation-associated protein 6 (CDKN1A)
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA6; MDA-6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Target Type Literature-reported Target
Gene Name CDKN1A
UniProt ID
CDN1A_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Denticleless protein homolog (DTL) Interacting Protein Interacting Protein Info
UniProt ID
DTL_HUMAN 
Synonyms CDT2; DCAF2; L2DTL; RAMP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [4]
2 Reconstituted Complex [5]
3 Reconstituted Complex [6]
Cell cycle related proteins [+] 7 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [10]
5 Affinity Capture-Western [11]
6 Reconstituted Complex [12]
7 Reconstituted Complex [6]
8 Yeast two hybrid [13]
9 Yeast two hybrid [14]
Interacting Target Name G1/S-specific cyclin-E1 (CCNE1) Literature-reported Target Interacting Protein Info
UniProt ID
CCNE1_HUMAN 
Synonyms G1/S-specific cyclin E; Cyclin E; CCNE
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [15]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [12]
5 Affinity Capture-Western [16]
6 Affinity Capture-Western [17]
7 Affinity Capture-Western [18]
8 Affinity Capture-Western [19]
9 Reconstituted Complex [12]
Interacting Protein Name G1/S-specific cyclin-D2 (CCND2) Interacting Protein Interacting Protein Info
UniProt ID
CCND2_HUMAN 
Synonyms KIAK0002; MPPH3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [18]
3 Affinity Capture-Western [20]
4 Yeast two hybrid [21]
5 Yeast two hybrid [14]
Interacting Target Name Cyclin D (CCND3) Literature-reported Target Interacting Protein Info
UniProt ID
CCND3_HUMAN 
Synonyms G1/S-specific cyclin-D3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-MS [7]
3 Yeast two hybrid [21]
4 Yeast two hybrid [14]
Interacting Target Name Cyclin A2 (CCNA2) Literature-reported Target Interacting Protein Info
UniProt ID
CCNA2_HUMAN 
Synonyms Cyclin-A2; Cyclin-A; Cyclin A; CCNA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-MS [7]
3 Affinity Capture-Western [9]
Interacting Target Name G1/S-specific cyclin-E2 (CCNE2) Literature-reported Target Interacting Protein Info
UniProt ID
CCNE2_HUMAN 
Synonyms G1/Sspecific cyclinE2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-MS [7]
3 Yeast two hybrid [23]
Interacting Protein Name Cyclin-A1 (CCNA1) Interacting Protein Interacting Protein Info
UniProt ID
CCNA1_HUMAN 
Synonyms CT146
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Co-localization [4]
3 Reconstituted Complex [24]
Kinases [+] 7 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-MS [7]
3 Affinity Capture-Western [25]
4 Affinity Capture-Western [26]
5 Affinity Capture-Western [27]
6 Affinity Capture-Western [28]
7 Affinity Capture-Western [16]
8 Affinity Capture-Western [29]
9 Affinity Capture-Western [17]
10 Affinity Capture-Western [11]
11 Affinity Capture-Western [18]
12 Affinity Capture-Western [15]
13 Affinity Capture-Western [30]
14 Affinity Capture-Western [31]
15 Affinity Capture-Western [32]
16 Affinity Capture-Western [33]
17 Affinity Capture-Western [34]
18 Reconstituted Complex [35]
19 Reconstituted Complex [12]
20 Reconstituted Complex [10]
Interacting Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target Interacting Protein Info
UniProt ID
CDK4_HUMAN 
Synonyms PSK-J3; Cell division protein kinase 4
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [30]
3 Affinity Capture-Western [26]
4 Affinity Capture-Western [10]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [11]
7 Affinity Capture-Western [20]
8 Affinity Capture-Western [31]
9 Reconstituted Complex [10]
10 Reconstituted Complex [12]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [24]
2 Co-localization [4]
3 Reconstituted Complex [24]
Interacting Target Name Cyclin-dependent kinase 6 (CDK6) Successful Target Interacting Protein Info
UniProt ID
CDK6_HUMAN 
Synonyms Serine/threonine-protein kinase PLSTIRE; Serine/threonine protein kinase PLSTIRE; Cell division protein kinase 6; CDKN6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [36]
2 Reconstituted Complex [37]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-Western [38]
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [39]
Interacting Target Name Cyclin-dependent kinase 5 (CDK5) Patented-recorded Target Interacting Protein Info
UniProt ID
CDK5_HUMAN 
Synonyms TPKII catalytic subunit; Tau protein kinase II catalytic subunit; Serine/threonine-protein kinase PSSALRE; Serine/threonine protein kinase PSSALRE; Proline-directed protein kinase F(A) (PDPK F(A)); Proline-directed protein kinase 33 kDa subunit; PDPK; Cyclin-dependent-like kinase 5; Cyclin-dependent kinase 5 (CDK5); Cell division protein kinase 5; CDKN5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Reconstituted Complex [35]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Target Name G2/mitotic-specific cyclin B1 (CCNB1) Patented-recorded Target Interacting Protein Info
UniProt ID
CCNB1_HUMAN 
Synonyms G2/mitotic-specific cyclin-B1; Cyclin B1; CCNB
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [38]
3 Affinity Capture-Western [9]
4 Reconstituted Complex [6]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Reconstituted Complex [41]
Peptidases [+] 2 Peptidases +
Interacting Target Name Caspase-3 (CASP3) Clinical trial Target Interacting Protein Info
UniProt ID
CASP3_HUMAN 
Synonyms Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [42]
2 Co-localization [4]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 11 (USP11) Interacting Protein Interacting Protein Info
UniProt ID
UBP11_HUMAN 
Synonyms UHX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [33]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Co-localization [44]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Co-localization [44]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Affinity Capture-Western [46]
3 Affinity Capture-Western [47]
4 Co-localization [4]
5 Reconstituted Complex [46]
6 Reconstituted Complex [48]
Other proteins [+] 8 Other proteins +
Interacting Target Name Proliferating cell nuclear antigen (PCNA) Clinical trial Target Interacting Protein Info
UniProt ID
PCNA_HUMAN 
Synonyms Cyclin
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-MS [7]
3 Affinity Capture-Western [49]
4 Affinity Capture-Western [26]
5 Affinity Capture-Western [28]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [50]
8 Affinity Capture-Western [38]
9 Affinity Capture-Western [34]
10 Affinity Capture-Western [51]
11 Affinity Capture-Western [52]
12 Affinity Capture-Western [53]
13 Co-crystal Structure [54]
14 Co-fractionation [55]
15 Co-fractionation [56]
16 Co-fractionation [57]
17 Reconstituted Complex [55]
18 Reconstituted Complex [6]
19 Reconstituted Complex [3]
20 Reconstituted Complex [58]
Interacting Target Name p53-binding protein Mdm4 (MDM4) Clinical trial Target Interacting Protein Info
UniProt ID
MDM4_HUMAN 
Synonyms Protein Mdmx; p53-binding protein Mdm4; Mdm2-like p53-binding protein; Double minute 4 protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [59]
2 Affinity Capture-Western [57]
3 Co-fractionation [57]
4 Reconstituted Complex [57]
Interacting Protein Name BRCA2 and CDKN1A-interacting protein (BCCIP) Interacting Protein Interacting Protein Info
UniProt ID
BCCIP_HUMAN 
Synonyms TOK.1; TOK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [60]
2 Reconstituted Complex [25]
3 Yeast two hybrid [25]
Interacting Protein Name DNA damage-binding protein 1 (DDB1) Interacting Protein Interacting Protein Info
UniProt ID
DDB1_HUMAN 
Synonyms DDBA; UV.DDB1; XAP1; XPCE; XPE; XPE.BF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
Interacting Target Name Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target Interacting Protein Info
UniProt ID
PARP1_HUMAN 
Synonyms Protein poly-ADP-ribosyltransferase PARP1; PPOL; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [61]
2 Reconstituted Complex [61]
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [62]
2 Co-localization [4]
Interacting Protein Name Dedicator of cytokinesis protein 7 (DOCK7) Interacting Protein Interacting Protein Info
UniProt ID
DOCK7_HUMAN 
Synonyms EIEE23; ZIR2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Yeast two hybrid [63]
Interacting Protein Name Tubulin alpha-1A chain (TUBA1A) Interacting Protein Interacting Protein Info
UniProt ID
TBA1A_HUMAN 
Synonyms B.ALPHA.1; LIS3; TUBA3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Yeast two hybrid [63]
References  Top
REF 1 PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 2008 Sep 15;22(18):2496-506.
REF 2 CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. J Biol Chem. 2008 Oct 24;283(43):29045-52.
REF 3 The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA. Mol Cell Biol. 2010 Sep;30(17):4120-33.
REF 4 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 5 An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Oncogene. 2010 May 6;29(18):2659-71.
REF 6 p21WAF1/CIP1 regulates the p300 sumoylation motif CRD1 through a C-terminal domain independently of cyclin/CDK binding. Cell Cycle. 2005 Aug;4(8):1113-9.
REF 7 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531.
REF 8 Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly. Circ Res. 2007 Jul 20;101(2):146-55.
REF 9 Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. J Biol Chem. 1996 May 31;271(22):13283-91.
REF 10 Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma. J Biol Chem. 2012 Nov 9;287(46):38523-30.
REF 11 Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A. J Pept Res. 2002 Nov;60(5):257-70.
REF 12 Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol. 1996 Sep;16(9):4673-82.
REF 13 Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80.
REF 14 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.
REF 15 Expression of p21Waf1/Cip1 and cyclin D1 is increased in butyrate-resistant HeLa cells. J Biol Chem. 2001 Oct 12;276(41):37815-20.
REF 16 P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest. Cancer Res. 2003 Jul 1;63(13):3840-4.
REF 17 Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 1998 Feb 15;12(4):456-61.
REF 18 Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis. FEBS Lett. 2006 Jun 26;580(15):3687-93.
REF 19 Cyclin E/Cdk2 activity is controlled by different mechanisms in the G0 and G1 phases of the cell cycle. Cell Growth Differ. 1996 Oct;7(10):1283-90.
REF 20 The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells. Retrovirology. 2004 Apr 13;1:6.
REF 21 rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Nat Commun. 2018 Sep 14;9(1):3747.
REF 22 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 23 Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. Oncogene. 1998 Nov 26;17(21):2787-98.
REF 24 Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol. 2006 Nov;26(22):8267-80.
REF 25 TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. J Biol Chem. 2000 Oct 6;275(40):31145-54.
REF 26 Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells. Mol Cell Biol. 2001 Aug;21(16):5644-57.
REF 27 Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell. 1998 Mar;1(4):553-63.
REF 28 Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene. 1999 Feb 4;18(5):1131-8.
REF 29 CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes. Eur J Cell Biol. 2003 May;82(5):253-61.
REF 30 p21(Cip1) up-regulated during histone deacetylase inhibitor-induced CD4(+) T-cell anergy selectively associates with mitogen-activated protein kinases. Immunology. 2010 Apr;129(4):589-99.
REF 31 Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2. Mol Cell Biol. 1996 Mar;16(3):762-70.
REF 32 C/EBP regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint. Cell Cycle. 2014;13(22):3602-10.
REF 33 Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4678-4683.
REF 34 S-phase Specific Downregulation of Human O6-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21cip1 Proteins in Glioma Cells. Neoplasia. 2018 Apr;20(4):305-323.
REF 35 Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division. J Mol Biol. 2005 Jun 17;349(4):764-73.
REF 36 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 37 Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90.
REF 38 Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage. J Biol Chem. 2001 Nov 16;276(46):42971-7.
REF 39 The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J Biol Chem. 2002 Aug 16;277(33):29792-802.
REF 40 Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression. Mol Cell Biol. 2003 Aug;23(16):5867-81.
REF 41 p21WAF1/CIP1 selectively controls the transcriptional activity of estrogen receptor alpha. Mol Cell Biol. 2005 Mar;25(6):2419-30.
REF 42 Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells. Eur J Biochem. 1998 Oct 1;257(1):242-8.
REF 43 Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia. 2002 Mar-Apr;4(2):171-80.
REF 44 Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016 Oct 6;538(7623):118-122.
REF 45 MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem. 2004 Apr 16;279(16):16000-6.
REF 46 MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J. 2003 Dec 1;22(23):6365-77.
REF 47 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol. 2010 Mar;30(6):1508-27.
REF 48 MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change. J Biol Chem. 2010 Jun 11;285(24):18407-14.
REF 49 Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome. Mol Cell. 2007 Jun 22;26(6):843-52.
REF 50 Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein. Exp Cell Res. 2001 May 1;265(2):234-41.
REF 51 p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. Oncogene. 2001 Jan 25;20(4):484-9.
REF 52 Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. J Biol Chem. 2010 Sep 3;285(36):27900-10.
REF 53 Increase of palmitic acid concentration impairs endothelial progenitor cell and bone marrow-derived progenitor cell bioavailability: role of the STAT5/PPAR transcriptional complex. Diabetes. 2013 Apr;62(4):1245-57.
REF 54 Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell. 1996 Oct 18;87(2):297-306.
REF 55 The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature. 1994 Jun 16;369(6481):574-8.
REF 56 Expression of a novel form of p21Cip1/Waf1 in UV-irradiated and transformed cells. Oncogene. 1998 Mar 12;16(10):1333-43.
REF 57 MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol Cell Biol. 2008 Feb;28(4):1218-29.
REF 58 Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. J Biol Chem. 2003 Oct 10;278(41):39265-8.
REF 59 14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53. J Biol Chem. 2011 Feb 18;286(7):5136-42.
REF 60 Inhibition of G1 to S cell cycle progression by BCCIP beta. Cell Cycle. 2004 Mar;3(3):343-8.
REF 61 p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1. DNA Repair (Amst). 2010 Jun 4;9(6):627-35.
REF 62 Cytoplasmic localization and ubiquitination of p21(Cip1) by reactive oxygen species. Biochem Biophys Res Commun. 2007 Jun 22;358(1):219-25.
REF 63 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.

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