Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T72507 Target Info
Target Name Cyclin D (CCND3)
Synonyms G1/S-specific cyclin-D3
Target Type Literature-reported Target
Gene Name CCND3
UniProt ID
CCND3_HUMAN 
Target Interacting Proteins  Top
Eukaryotic initiation factors [+] 1 Eukaryotic initiation factors +
Interacting Protein Name Eukaryotic translation initiation factor 3 subunit K (EIF3K) Interacting Protein Interacting Protein Info
UniProt ID
EIF3K_HUMAN 
Synonyms EIF3.p28; EIF3S12; HSPC029; M9; MSTP001; PLAC.24; PLAC24; PRO1474; PTD001
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [1]
2 Yeast two hybrid [1]
3 Yeast two hybrid [2]
Kinases [+] 3 Kinases +
Interacting Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target Interacting Protein Info
UniProt ID
CDK4_HUMAN 
Synonyms PSK-J3; Cell division protein kinase 4
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [7]
6 Affinity Capture-Western [8]
7 Reconstituted Complex [9]
8 Yeast two hybrid [10]
9 Yeast two hybrid [11]
10 Yeast two hybrid [2]
11 Yeast two hybrid [12]
12 Yeast two hybrid [13]
Interacting Target Name Cyclin-dependent kinase 6 (CDK6) Successful Target Interacting Protein Info
UniProt ID
CDK6_HUMAN 
Synonyms Serine/threonine-protein kinase PLSTIRE; Serine/threonine protein kinase PLSTIRE; Cell division protein kinase 6; CDKN6
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [7]
4 Affinity Capture-Western [6]
5 Reconstituted Complex [9]
6 Yeast two hybrid [11]
7 Yeast two hybrid [13]
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [7]
4 Affinity Capture-Western [6]
Other proteins [+] 4 Other proteins +
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [6]
5 Co-localization [14]
6 Reconstituted Complex [9]
7 Reconstituted Complex [15]
8 Yeast two hybrid [10]
9 Yeast two hybrid [11]
10 Yeast two hybrid [2]
11 Yeast two hybrid [13]
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [16]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [17]
6 Affinity Capture-Western [18]
7 Affinity Capture-Western [7]
8 Reconstituted Complex [19]
9 Yeast two hybrid [10]
Interacting Protein Name Dysbindin (DTNBP1) Interacting Protein Interacting Protein Info
UniProt ID
DTBP1_HUMAN 
Synonyms BLOC1S8; DBND; HPS7; My031; SDY
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Yeast two hybrid [10]
Interacting Protein Name Protein MCM10 homolog (MCM10) Interacting Protein Interacting Protein Info
UniProt ID
MCM10_HUMAN 
Synonyms CNA43; DNA43
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [9]
References  Top
REF 1 Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3. FEBS Lett. 2004 Aug 27;573(1-3):139-46.
REF 2 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 5 A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95. Biochem J. 2004 Mar 1;378(Pt 2):673-9.
REF 6 Differential modulation of G1-S-phase cyclin-dependent kinase 2/cyclin complexes occurs during the acquisition of a polyploid DNA content. Cell Growth Differ. 1998 Aug;9(8):639-50.
REF 7 Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol Cell Biol. 2006 Jul;26(13):5070-85.
REF 8 Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model. Retrovirology. 2013 Jul 23;10:75.
REF 9 Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90.
REF 10 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 11 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 12 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.
REF 13 rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Nat Commun. 2018 Sep 14;9(1):3747.
REF 14 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 15 Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol. 1996 Sep;16(9):4673-82.
REF 16 Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells. Oncogene. 1999 Nov 4;18(46):6388-97.
REF 17 Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. J Proteome Res. 2013 Jul 5;12(7):3181-92.
REF 18 Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 1996 Dec 2;15(23):6595-604.
REF 19 Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence. Oncogene. 2001 Apr 12;20(16):2000-9.
REF 20 Schizophrenia susceptibility gene product dysbindin-1 regulates the homeostasis of cyclin D1. Biochim Biophys Acta. 2016 Aug;1862(8):1383-91.

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