Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T13928 Target Info
Target Name Deneddylase-1 (SENP8)
Synonyms Sentrin/SUMO-specific protease SENP8; Sentrin-specific protease 8; Protease, cysteine 2; PRSC2; NEDP1; NEDD8-specific protease 1; FKSG8; DEN1
Target Type Literature-reported Target
Gene Name SENP8
Biochemical Class Peptidase
UniProt ID
SENP8_HUMAN 
Target Interacting Proteins  Top
Cullins [+] 1 Cullins +
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
References  Top
REF 1 A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. Nat Cell Biol. 2010 Apr;12(4):351-61.
REF 2 Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome. PLoS Genet. 2013;9(2):e1003275.
REF 3 A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. Anal Biochem. 2009 Jul 1;390(1):85-7.
REF 4 Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J. 2005 Apr 6;24(7):1341-51.
REF 5 Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. J Mol Biol. 2005 Jan 7;345(1):141-51.
REF 6 DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem. 2003 Aug 1;278(31):28882-91.

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