Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Tumor suppressor p53-binding protein 1 (TP53BP1) | Literature-reported | Target Info | ||
| UniProt ID | TP53B_HUMAN | ||||
| Gene Name | TP53BP1 | ||||
| Gene ID | 7158 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Polo-like kinase 1 (PLK1) | Target Info | PPI Info | [1] | |
| ATM serine/threonine kinase (ATM) | Target Info | PPI Info | [2] | ||
| Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [3] | ||
| Interacting Literature-reported Target(s) | Gamma-Histone H2AX (H2AFX) | Target Info | PPI Info | [4] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol. 2010 Jan 26;8(1):e1000287. | ||||
| REF 2 | Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem. 2003 May 30;278(22):19579-82. | ||||
| REF 3 | The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function. Cell Signal. 2015 Sep;27(9):1763-71. | ||||
| REF 4 | MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003 Feb 27;421(6926):961-6. | ||||
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