| References |
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| REF 1 |
RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. J Biol Chem. 2004 Jan 16;279(3):1872-7.
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| REF 2 |
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999 May 15;13(10):1297-308.
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| REF 3 |
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014 Nov 3;33(21):2581-96.
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| REF 4 |
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 2004 Feb;6(2):97-105.
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| REF 5 |
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. EMBO J. 2010 Nov 17;29(22):3750-61.
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| REF 6 |
MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J Biol Chem. 1997 Dec 19;272(51):32056-60.
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| REF 7 |
Subdomain VIII is a specificity-determining region in MEKK1. J Biol Chem. 2003 Nov 28;278(48):48498-505.
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| REF 8 |
MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem. 2000 Dec 22;275(51):40120-7.
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| REF 9 |
Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Mol Cell Biol. 2002 Feb;22(3):737-49.
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| REF 10 |
Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J Biol Chem. 1998 Aug 28;273(35):22681-92.
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| REF 11 |
Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr;20(7):2334-42.
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| REF 12 |
MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein. J Biol Chem. 2010 Dec 10;285(50):38818-31.
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| REF 13 |
Nuclear Localization Signal and p53 Binding Site in MAP/ERK Kinase Kinase 1 (MEKK1). J Cell Biochem. 2015 Dec;116(12):2903-14.
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| REF 14 |
CSN6 positively regulates c-Jun in a MEKK1-dependent manner. Cell Cycle. 2015;14(19):3079-87.
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| REF 15 |
1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2. J Biol Chem. 2003 Aug 15;278(33):30711-8.
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| REF 16 |
Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6.
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| REF 17 |
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
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| REF 18 |
Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/-catenin signaling. Hum Mol Genet. 2014 Feb 15;23(4):1073-83.
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| REF 19 |
Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways. J Biol Chem. 2002 May 17;277(20):17706-12.
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