Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T06031 Target Info
Target Name MAPK/ERK kinase kinase 1 (MAP3K1)
Synonyms Mitogenactivated protein kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase 1; MEKK1; MEKK 1; MEKK; MEK kinase 1; MAPKKK1
Target Type Clinical trial Target
Gene Name MAP3K1
Biochemical Class Kinase
UniProt ID
M3K1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Transforming protein RhoA (RHOA) Discontinued Target Interacting Protein Info
UniProt ID
RHOA_HUMAN 
Synonyms Transforming protein RhoA; RHO12; Rho cDNA clone 12; h12; ARHA; ARH12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [1]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Biochemical Activity [3]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name DDB1- and CUL4-associated factor 7 (DCAF7) Interacting Protein Interacting Protein Info
UniProt ID
DCAF7_HUMAN 
Synonyms AN11; HAN11; SWAN.1; WDR68
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-localization [5]
Kinases [+] 4 Kinases +
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Biochemical Activity [7]
3 Reconstituted Complex [6]
Interacting Target Name Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target Interacting Protein Info
UniProt ID
MK01_HUMAN 
Synonyms PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [1]
Interacting Target Name MEK kinase kinase 2 (MAP4K2) Patented-recorded Target Interacting Protein Info
UniProt ID
M4K2_HUMAN 
Synonyms RAB8IP; Rab8-interacting protein; Mitogen-activated protein kinase kinase kinase kinase 2; MEKKK 2; MAPK/ERK kinase kinase kinase 2; Germinal center kinase; GCK; GC kinase; B lymphocyte serine/threonine-protein kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) Interacting Protein Interacting Protein Info
UniProt ID
MP2K4_HUMAN 
Synonyms JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK.1; SAPKK1; SEK1; SERK1; SKK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [1]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [13]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Biochemical Activity [15]
Other proteins [+] 2 Other proteins +
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Co-localization [17]
Interacting Protein Name Axin-1 (AXIN1) Interacting Protein Interacting Protein Info
UniProt ID
AXIN1_HUMAN 
Synonyms AXIN; PPP1R49
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [18]
2 Affinity Capture-Western [19]
References  Top
REF 1 RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. J Biol Chem. 2004 Jan 16;279(3):1872-7.
REF 2 Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999 May 15;13(10):1297-308.
REF 3 The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014 Nov 3;33(21):2581-96.
REF 4 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 2004 Feb;6(2):97-105.
REF 5 The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. EMBO J. 2010 Nov 17;29(22):3750-61.
REF 6 MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J Biol Chem. 1997 Dec 19;272(51):32056-60.
REF 7 Subdomain VIII is a specificity-determining region in MEKK1. J Biol Chem. 2003 Nov 28;278(48):48498-505.
REF 8 MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem. 2000 Dec 22;275(51):40120-7.
REF 9 Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Mol Cell Biol. 2002 Feb;22(3):737-49.
REF 10 Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J Biol Chem. 1998 Aug 28;273(35):22681-92.
REF 11 Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr;20(7):2334-42.
REF 12 MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein. J Biol Chem. 2010 Dec 10;285(50):38818-31.
REF 13 Nuclear Localization Signal and p53 Binding Site in MAP/ERK Kinase Kinase 1 (MEKK1). J Cell Biochem. 2015 Dec;116(12):2903-14.
REF 14 CSN6 positively regulates c-Jun in a MEKK1-dependent manner. Cell Cycle. 2015;14(19):3079-87.
REF 15 1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2. J Biol Chem. 2003 Aug 15;278(33):30711-8.
REF 16 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6.
REF 17 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 18 Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/-catenin signaling. Hum Mol Genet. 2014 Feb 15;23(4):1073-83.
REF 19 Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways. J Biol Chem. 2002 May 17;277(20):17706-12.

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