Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T21782 Target Info
Target Name Proliferating cell nuclear antigen (PCNA)
Synonyms Cyclin
Target Type Clinical trial Target
Gene Name PCNA
UniProt ID
PCNA_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Protein Name X-ray repair cross-complementing protein 6 (XRCC6) Interacting Protein Interacting Protein Info
UniProt ID
XRCC6_HUMAN 
Synonyms CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
4 Fluorescence Resonance Energy Transfer [3]
Interacting Protein Name ATPase family AAA domain-containing protein 5 (ATAD5) Interacting Protein Interacting Protein Info
UniProt ID
ATAD5_HUMAN 
Synonyms C17orf41; ELG1; FRAG1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
3 Reconstituted Complex [5]
Interacting Protein Name Werner syndrome ATP-dependent helicase (WRN) Interacting Protein Interacting Protein Info
UniProt ID
WRN_HUMAN 
Synonyms RECQ3; RECQL2; RECQL3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Fluorescence Resonance Energy Transfer [7]
3 Reconstituted Complex [8]
Interacting Target Name X-ray repair cross-complementing 5 (Ku80) Literature-reported Target Interacting Protein Info
UniProt ID
XRCC5_HUMAN 
Synonyms X-ray repair cross-complementing protein 5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); TLAA; Thyroid-lupus autoantigen; Nuclear factor IV; Lupus Ku autoantigen protein p86; Ku86; G22P2; DNA repair protein XRCC5; CTCBF; CTC85; CTC box-binding factor 85 kDa subunit; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase 2 subunit 2; 86 kDa subunit of Ku antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Activator-1 proteins [+] 6 Activator-1 proteins +
Interacting Protein Name Replication factor C subunit 1 (RFC1) Interacting Protein Interacting Protein Info
UniProt ID
RFC1_HUMAN 
Synonyms A1; MHCBFB; PO.GA; RECC1; RFC; RFC140
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [9]
4 Affinity Capture-MS [10]
5 Affinity Capture-Western [11]
6 Affinity Capture-Western [1]
7 Affinity Capture-Western [12]
8 Co-fractionation [13]
9 Reconstituted Complex [14]
10 Reconstituted Complex [15]
Interacting Protein Name Replication factor C subunit 4 (RFC4) Interacting Protein Interacting Protein Info
UniProt ID
RFC4_HUMAN 
Synonyms A1; RFC37
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [10]
4 Affinity Capture-Western [1]
5 Co-fractionation [13]
6 Reconstituted Complex [16]
Interacting Protein Name Replication factor C subunit 2 (RFC2) Interacting Protein Interacting Protein Info
UniProt ID
RFC2_HUMAN 
Synonyms RFC40
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [10]
4 Reconstituted Complex [16]
5 Reconstituted Complex [17]
Interacting Protein Name Chromosome transmission fidelity protein 18 homolog (CHTF18) Interacting Protein Interacting Protein Info
UniProt ID
CTF18_HUMAN 
Synonyms C16orf41; C321D2.2; C321D2.3; C321D2.4; CHL12; Ctf18; RUVBL
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [1]
4 Co-fractionation [18]
Interacting Protein Name Replication factor C subunit 3 (RFC3) Interacting Protein Interacting Protein Info
UniProt ID
RFC3_HUMAN 
Synonyms RFC38
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [10]
3 Co-fractionation [18]
Interacting Protein Name Replication factor C subunit 5 (RFC5) Interacting Protein Interacting Protein Info
UniProt ID
RFC5_HUMAN 
Synonyms RFC36
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [10]
3 Reconstituted Complex [16]
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RAD18 (RAD18) Interacting Protein Interacting Protein Info
UniProt ID
RAD18_HUMAN 
Synonyms RNF73
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Affinity Capture-Western [20]
3 Affinity Capture-Western [10]
4 Reconstituted Complex [10]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Biochemical Activity [22]
3 Reconstituted Complex [21]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Denticleless protein homolog (DTL) Interacting Protein Interacting Protein Info
UniProt ID
DTL_HUMAN 
Synonyms CDT2; DCAF2; L2DTL; RAMP
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [24]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [25]
6 Co-localization [26]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Reconstituted Complex [28]
Ester hydrolases [+] 3 Ester hydrolases +
Interacting Protein Name Flap endonuclease 1 (FEN1) Interacting Protein Interacting Protein Info
UniProt ID
FEN1_HUMAN 
Synonyms FEN.1; MF1; RAD2
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [29]
4 Affinity Capture-Western [30]
5 Co-crystal Structure [31]
6 Co-crystal Structure [32]
7 Protein-peptide [32]
8 Reconstituted Complex [33]
9 Reconstituted Complex [34]
10 Reconstituted Complex [35]
11 Reconstituted Complex [36]
12 Reconstituted Complex [37]
13 Yeast two hybrid [37]
14 Yeast two hybrid [38]
Interacting Target Name M-phase inducer phosphatase 3 (MPIP3) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP3_HUMAN 
Synonyms Dual specificity phosphatase Cdc25C; Cdc25C phosphatase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Affinity Capture-Western [40]
3 Reconstituted Complex [39]
Interacting Protein Name DNA mismatch repair protein Msh6 (MSH6) Interacting Protein Interacting Protein Info
UniProt ID
MSH6_HUMAN 
Synonyms GTBP; GTMBP; HNPCC5; HSAP; p160
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [24]
Kinases [+] 8 Kinases +
Interacting Protein Name DNA polymerase eta (POLH) Interacting Protein Interacting Protein Info
UniProt ID
POLH_HUMAN 
Synonyms RAD30; RAD30A; XP.V; XPV
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Affinity Capture-Western [42]
3 Affinity Capture-Western [43]
4 Affinity Capture-Western [44]
5 Affinity Capture-Western [19]
6 Affinity Capture-Western [45]
7 Affinity Capture-Western [46]
8 Affinity Capture-Western [47]
9 Reconstituted Complex [48]
10 Reconstituted Complex [45]
Interacting Protein Name DNA polymerase delta catalytic subunit (POLD1) Interacting Protein Interacting Protein Info
UniProt ID
DPOD1_HUMAN 
Synonyms CDC2; CRCS10; MDPL; POLD
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [10]
4 Affinity Capture-Western [49]
5 Affinity Capture-Western [50]
6 Affinity Capture-Western [51]
7 Co-fractionation [52]
8 Reconstituted Complex [52]
9 Reconstituted Complex [53]
Interacting Target Name Insulin-like growth factor I receptor (IGF1R) Successful Target Interacting Protein Info
UniProt ID
IGF1R_HUMAN 
Synonyms Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [54]
2 Affinity Capture-Western [20]
3 Biochemical Activity [20]
4 Co-localization [20]
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [55]
2 Affinity Capture-MS [56]
3 Affinity Capture-Western [57]
4 Affinity Capture-Western [58]
Interacting Protein Name DNA polymerase delta subunit 2 (POLD2) Interacting Protein Interacting Protein Info
UniProt ID
DPOD2_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [22]
3 Co-fractionation [52]
4 Reconstituted Complex [59]
Interacting Protein Name DNA polymerase epsilon catalytic subunit A (POLE) Interacting Protein Interacting Protein Info
UniProt ID
DPOE1_HUMAN 
Synonyms CRCS12; FILS; POLE1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [51]
4 Co-fractionation [18]
Interacting Protein Name DNA polymerase nu (POLN) Interacting Protein Interacting Protein Info
UniProt ID
DPOLN_HUMAN 
Synonyms POL4P
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [60]
2 Affinity Capture-Western [61]
3 Co-fractionation [53]
4 Co-localization [53]
Interacting Protein Name DNA polymerase iota (POLI) Interacting Protein Interacting Protein Info
UniProt ID
POLI_HUMAN 
Synonyms RAD30B; RAD3OB
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Co-crystal Structure [62]
3 Co-fractionation [63]
4 Yeast two hybrid [44]
Ligases [+] 1 Ligases +
Interacting Protein Name DNA ligase 1 (LIG1) Interacting Protein Interacting Protein Info
UniProt ID
DNLI1_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [10]
3 Co-localization [64]
4 Reconstituted Complex [14]
One-carbon transferases [+] 2 One-carbon transferases +
Interacting Target Name DNA [cytosine-5]-methyltransferase 1 (DNMT1) Clinical trial Target Interacting Protein Info
UniProt ID
DNMT1_HUMAN 
Synonyms MCMT; M.HsaI; Dnmt1; DNMT; DNA MTase HsaI; DNA methyltransferase HsaI; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine5)methyltransferase 1; CXXC-type zinc finger protein 9; CXXCtype zinc finger protein 9; CXXC9; AIM
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [9]
4 Affinity Capture-Western [65]
5 Affinity Capture-Western [66]
6 Reconstituted Complex [67]
Interacting Target Name O-6-methylguanine-DNA-alkyltransferase (MGMT) Clinical trial Target Interacting Protein Info
UniProt ID
MGMT_HUMAN 
Synonyms Methylated-DNA--protein-cysteine methyltransferase; Human O(6)-alkylguanine-DNA alkyltransferase; 6-O-methylguanine-DNA methyltransferase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [68]
2 Reconstituted Complex [58]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [69]
2 Co-localization [69]
Other proteins [+] 11 Other proteins +
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [55]
2 Affinity Capture-MS [56]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [30]
5 Affinity Capture-Western [70]
6 Affinity Capture-Western [71]
7 Affinity Capture-Western [40]
8 Affinity Capture-Western [58]
9 Affinity Capture-Western [72]
10 Affinity Capture-Western [73]
11 Affinity Capture-Western [74]
12 Affinity Capture-Western [75]
13 Affinity Capture-Western [76]
14 Affinity Capture-Western [77]
15 Affinity Capture-Western [78]
16 Protein-peptide [79]
17 Protein-peptide [32]
18 Reconstituted Complex [15]
19 Reconstituted Complex [34]
20 Reconstituted Complex [80]
Interacting Protein Name DNA polymerase delta subunit 3 (POLD3) Interacting Protein Interacting Protein Info
UniProt ID
DPOD3_HUMAN 
Synonyms P66; P68; PPP1R128
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Co-fractionation [52]
4 Fluorescence Resonance Energy Transfer [3]
5 Protein-peptide [32]
6 Reconstituted Complex [52]
Interacting Protein Name PCNA-associated factor (PCLAF) Interacting Protein Interacting Protein Info
UniProt ID
PAF15_HUMAN 
Synonyms NS5ATP9; OEATC; OEATC.1; OEATC1; PAF; PAF15; p15(PAF); p15/PAF; p15PAF
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-MS [55]
3 Affinity Capture-MS [56]
4 Affinity Capture-MS [4]
5 Affinity Capture-Western [81]
6 Yeast two hybrid [38]
Interacting Protein Name Replication factor A protein 1 (RPA1) Interacting Protein Interacting Protein Info
UniProt ID
RFA1_HUMAN 
Synonyms HSSB; MST075; REPA1; RF.A; RP.A; RPA70
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [51]
4 Affinity Capture-Western [77]
5 Affinity Capture-Western [82]
Interacting Protein Name Apoptosis regulatory protein Siva (SIVA1) Interacting Protein Interacting Protein Info
UniProt ID
SIVA_HUMAN 
Synonyms CD27BP; SIVA; Siva.1; Siva.2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [10]
4 Reconstituted Complex [10]
5 Yeast two hybrid [83]
Interacting Protein Name Chromatin assembly factor 1 subunit A (CHAF1A) Interacting Protein Interacting Protein Info
UniProt ID
CAF1A_HUMAN 
Synonyms CAF.1; CAF1; CAF1B; CAF1P150; P150
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [49]
3 Affinity Capture-Western [84]
4 Reconstituted Complex [85]
Interacting Protein Name DNA damage-inducible transcript 1 protein (GADD45A) Interacting Protein Interacting Protein Info
UniProt ID
GA45A_HUMAN 
Synonyms DDIT1; GADD45
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [86]
2 Affinity Capture-Western [87]
3 Affinity Capture-Western [88]
4 Yeast two hybrid [87]
Interacting Protein Name SprT-like domain-containing protein Spartan (SPRTN) Interacting Protein Interacting Protein Info
UniProt ID
SPRTN_HUMAN 
Synonyms C1orf124; DDDL1880; DVC1; PRO4323; Spartan; dJ876B10.3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [89]
2 Co-localization [89]
3 Co-localization [90]
4 Reconstituted Complex [91]
Interacting Target Name Annexin A2 (ANXA2) Literature-reported Target Interacting Protein Info
UniProt ID
ANXA2_HUMAN 
Synonyms Protein I; Placental anticoagulant protein IV; PAP-IV; p36; LPC2D; Lipocortin II; Chromobindin-8; Calpactin-1 heavy chain; Calpactin I heavy chain; CAL1H; ANX2L4; ANX2; Annexin-2; Annexin II
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [92]
3 Affinity Capture-Western [1]
Interacting Protein Name DNA repair protein XRCC1 (XRCC1) Interacting Protein Interacting Protein Info
UniProt ID
XRCC1_HUMAN 
Synonyms RCC
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [93]
2 Affinity Capture-Western [51]
3 Fluorescence Resonance Energy Transfer [93]
Interacting Target Name Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target Interacting Protein Info
UniProt ID
PARP1_HUMAN 
Synonyms Protein poly-ADP-ribosyltransferase PARP1; PPOL; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [94]
2 Reconstituted Complex [94]
References  Top
REF 1 A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. J Biol Chem. 2002 Oct 25;277(43):40362-7.
REF 2 Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells. Nucleic Acids Res. 2001 Mar 15;29(6):1341-51.
REF 3 The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance. J Biol Chem. 2014 May 9;289(19):13627-37.
REF 4 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 5 Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. J Biol Chem. 2010 Apr 2;285(14):10362-9.
REF 6 Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA. Mech Ageing Dev. 2003 Feb;124(2):167-74.
REF 7 WRN interacts physically and functionally with the recombination mediator protein RAD52. J Biol Chem. 2003 Sep 19;278(38):36476-86.
REF 8 Characterization of the human and mouse WRN 3'-->5' exonuclease. Nucleic Acids Res. 2000 Jun 15;28(12):2396-405.
REF 9 Proliferating cell nuclear antigen interacts with the CRL4 ubiquitin ligase subunit CDT2 in DNA synthesis-induced degradation of CDT1. J Biol Chem. 2018 Dec 7;293(49):18879-18889.
REF 10 SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. J Cell Biol. 2014 Jun 23;205(6):811-27.
REF 11 The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins. J Mol Med (Berl). 1999 Apr;77(4):386-92.
REF 12 Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block. Oncogene. 2002 Oct 31;21(50):7710-9.
REF 13 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 14 DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories. EMBO J. 1998 Jul 1;17(13):3786-95.
REF 15 A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammal... EMBO J. 1996 Aug 15;15(16):4423-33.
REF 16 A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme. J Biol Chem. 1997 Jul 25;272(30):18974-81.
REF 17 The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):6-10.
REF 18 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 19 A non-catalytic role of DNA polymerase in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks. Nucleic Acids Res. 2013 Mar 1;41(5):3079-93.
REF 20 Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage. J Biol Chem. 2017 Nov 3;292(44):18227-18239.
REF 21 Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis. Nature. 2001 Mar 15;410(6826):387-91.
REF 22 CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res. 2014 Jul;42(13):8433-48.
REF 23 L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. Cell Cycle. 2006 Aug;5(15):1675-80.
REF 24 N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1. J Biol Chem. 2011 Aug 26;286(34):29531-9.
REF 25 14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation. Mol Cell Biol. 2014 Nov;34(21):4049-61.
REF 26 Mutations at multiple CDK phosphorylation consensus sites on Cdt2 increase the affinity of CRL4Cdt2 for PCNA and its ubiquitination activity in S phase. Genes Cells. 2018 Mar;23(3):200-213.
REF 27 Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev. 1993 Aug;7(8):1572-83.
REF 28 D-type cyclin-binding regions of proliferating cell nuclear antigen. J Biol Chem. 1994 Apr 15;269(15):11030-6.
REF 29 Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer Res. 2012 Jul 1;72(13):3217-27.
REF 30 Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol. 2006 Dec;8(12):1359-68.
REF 31 Structure of monoubiquitinated PCNA: implications for DNA polymerase switching and Okazaki fragment maturation. Cell Cycle. 2012 Jun 1;11(11):2128-36.
REF 32 Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1. Structure. 2004 Dec;12(12):2209-19.
REF 33 Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Oncogene. 2003 Jul 10;22(28):4301-13.
REF 34 Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen. EMBO J. 1998 Apr 15;17(8):2412-25.
REF 35 The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21. J Biol Chem. 1997 Sep 26;272(39):24522-9.
REF 36 p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11597-602.
REF 37 Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA. Nucleic Acids Res. 1996 Jun 1;24(11):2036-43.
REF 38 p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. Oncogene. 2001 Jan 25;20(4):484-9.
REF 39 Cdc25C interacts with PCNA at G2/M transition. Oncogene. 2002 Mar 7;21(11):1717-26.
REF 40 Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage. J Biol Chem. 2001 Nov 16;276(46):42971-7.
REF 41 Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol Cell. 2004 May 21;14(4):491-500.
REF 42 Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol Cell. 2010 Feb 12;37(3):396-407.
REF 43 The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol in response to oxidative DNA damage in human cells. Mol Cell. 2011 Aug 19;43(4):649-62.
REF 44 Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota. J Biol Chem. 2004 Nov 12;279(46):48360-8.
REF 45 The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells. Mol Cell. 2010 Jan 15;37(1):79-89.
REF 46 Aberrant C-terminal domain of polymerase targets the functional enzyme to the proteosomal degradation pathway. DNA Repair (Amst). 2015 May;29:154-65.
REF 47 NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase in response to oxidative DNA damage. Protein Cell. 2018 Apr;9(4):365-379.
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