Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Insulin-like growth factor I receptor (IGF1R) | Successful | Target Info | ||
| UniProt ID | IGF1R_HUMAN | ||||
| Gene Name | IGF1R | ||||
| Gene ID | 3480 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [1] | |
| Protein-tyrosine phosphatase SHP-2 (PTPN11) | Target Info | PPI Info | [2] | ||
| Proliferating cell nuclear antigen (PCNA) | Target Info | PPI Info | [3] | ||
| Insulin receptor substrate-1 (IRS1) | Target Info | PPI Info | [2] | ||
| Interacting Literature-reported Target(s) | Receptor of activated protein C kinase 1 (RACK1) | Target Info | PPI Info | [4] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8247-52. | ||||
| REF 2 | Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol Cell Biol. 1999 Apr;19(4):3125-35. | ||||
| REF 3 | Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage. J Biol Chem. 2017 Nov 3;292(44):18227-18239. | ||||
| REF 4 | RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Mol Cell Biol. 2002 Apr;22(7):2345-65. | ||||
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