Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T93712 Target Info
Target Name Receptor of activated protein C kinase 1 (RACK1)
Synonyms Small ribosomal subunit protein RACK1; Receptor of activated protein C kinase 1, N-terminally processed; Receptor for activated C kinase; Human lung cancer oncogene 7 protein; HLC-7; Guanine nucleotide-binding protein subunit beta-like protein 12.3; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-2-like 1; GNB2L1; Cell proliferation-inducing gene 21 protein
Target Type Literature-reported Target
Gene Name RACK1
Biochemical Class WD repeat G protein beta family. Ribosomal protein RACK1 subfamily
UniProt ID
RACK1_HUMAN 
Target Interacting Proteins  Top
Cytokine receptors [+] 1 Cytokine receptors +
Interacting Target Name Interferon alpha/beta receptor 2 (IFNAR2) Successful Target Interacting Protein Info
UniProt ID
INAR2_HUMAN 
Synonyms Type I interferon receptor 2; Type I interferon receptor; Interferon alpha/beta receptor; Interferon alpha binding protein; IFN-R-2; IFN-R; IFNARB; IFN-alpha-REC; IFN-alpha/beta receptor 2; IFN-alpha binding protein; IFNABR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [1]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Adrenergic receptor beta-2 (ADRB2) Successful Target Interacting Protein Info
UniProt ID
ADRB2_HUMAN 
Synonyms Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Beta-2 adrenergic receptor; B2AR; ADRB2R
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [3]
4 Protein-Fragment Complementation Assay [3]
Kinases [+] 2 Kinases +
Interacting Target Name Insulin-like growth factor I receptor (IGF1R) Successful Target Interacting Protein Info
UniProt ID
IGF1R_HUMAN 
Synonyms Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
Interacting Target Name Protein kinase C beta (PRKCB) Clinical trial Target Interacting Protein Info
UniProt ID
KPCB_HUMAN 
Synonyms Protein kinase C beta type; Protein Kinase C beta; PRKCB1; PKC-beta; PKC-B; PKCB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [8]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Yeast two hybrid [10]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [13]
Other proteins [+] 2 Other proteins +
Interacting Target Name Phosphodiesterase 4D (PDE4D) Successful Target Interacting Protein Info
UniProt ID
PDE4D_HUMAN 
Synonyms PDE43; DPDE3; cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Yeast two hybrid [15]
Interacting Target Name TAR DNA binding protein 43 (TARDBP) Clinical trial Target Interacting Protein Info
UniProt ID
TADBP_HUMAN 
Synonyms TDP-43; TDP43; TAR DNA-binding protein 43
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Yeast two hybrid [17]
References  Top
REF 1 Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor. J Immunol. 2000 Nov 1;165(9):5127-32.
REF 2 The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor. J Biol Chem. 2001 Jun 22;276(25):22948-53.
REF 3 CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human adrenergic receptor. Biochem Biophys Res Commun. 2014 Mar 21;445(4):746-56.
REF 4 Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Mol Endocrinol. 2013 Aug;27(8):1245-66.
REF 5 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 6 RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Mol Cell Biol. 2002 Apr;22(7):2345-65.
REF 7 Coordinated movement of RACK1 with activated betaIIPKC. J Biol Chem. 1999 Sep 17;274(38):27039-46.
REF 8 The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway. Oncogene. 2015 Mar 5;34(10):1280-91.
REF 9 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
REF 10 Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. J Proteome Res. 2008 Sep;7(9):3879-89.
REF 11 The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Rep. 2016 Jun 28;16(1):37-47.
REF 12 TRAF6 upregulates expression of HIF-1 and promotes tumor angiogenesis. Cancer Res. 2013 Aug 1;73(15):4950-9.
REF 13 Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 2007 Nov 16;282(46):33358-66.
REF 14 Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J Biol Chem. 2009 Jun 12;284(24):16170-82.
REF 15 The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform. J Biol Chem. 1999 May 21;274(21):14909-17.
REF 16 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. J Proteome Res. 2010 Feb 5;9(2):1104-20.
REF 17 UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. J Biol Chem. 2014 Jul 4;289(27):19164-79.

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