Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T38257 Target Info
Target Name Phosphatase and tensin homolog (PTEN)
Synonyms TEP1; Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; MMAC1
Target Type Literature-reported Target
Gene Name PTEN
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PTEN_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name E3 ubiquitin-protein ligase NEDD4 (NEDD4) Literature-reported Target Interacting Protein Info
UniProt ID
NEDD4_HUMAN 
Synonyms Neural precursor cell expressed developmentally down-regulated protein 4; NEDD4-1; NEDD-4; KIAA0093; HECT-type E3 ubiquitin transferase NEDD4; Cell proliferation-inducing gene 53 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Protein Name WW domain-containing protein 1 (WWP1) Interacting Protein Interacting Protein Info
UniProt ID
WWP1_HUMAN 
Synonyms WW domain-containing protein 1; Tiul1; TGIF-interacting ubiquitin ligase 1; NEDD4-like E3 ubiquitin-protein ligase WWP1; HECT-type E3 ubiquitin transferase WWP1; Atrophin-1-interacting protein 5; AIP5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Ezrin-radixin-moesin-binding phosphoprotein 50 (SLC9A3R1) Interacting Protein Interacting Protein Info
UniProt ID
NHRF1_HUMAN 
Synonyms EBP50; NHERF; NHERF.1; NHERF1; NPHLOP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [5]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Fizzy-related protein homolog (FZR1) Interacting Protein Interacting Protein Info
UniProt ID
FZR1_HUMAN 
Synonyms CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [7]
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Target Name Heat shock protein 90 beta (HSP90B) Clinical trial Target Interacting Protein Info
UniProt ID
HS90B_HUMAN 
Synonyms HSP84; HSP 84; Heat shock 84 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Reconstituted Complex [8]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Reconstituted Complex [8]
Kinases [+] 3 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Fluorescence Resonance Energy Transfer [10]
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Reconstituted Complex [12]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Biochemical Activity [14]
Peptidases [+] 3 Peptidases +
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 13 (USP13) Interacting Protein Interacting Protein Info
UniProt ID
UBP13_HUMAN 
Synonyms ISOT3; IsoT.3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [16]
3 Co-localization [16]
4 Reconstituted Complex [15]
Interacting Target Name Herpesvirus ubiquitin-specific protease (HAUSP) Preclinical Target Interacting Protein Info
UniProt ID
UBP7_HUMAN 
Synonyms Ubiquitin-specific-processing protease 7; Ubiquitin thioesterase 7; Ubiquitin carboxyl-terminal hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [17]
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 10 (USP10) Interacting Protein Interacting Protein Info
UniProt ID
UBP10_HUMAN 
Synonyms UBPO
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [18]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Reconstituted Complex [20]
Ribosomal proteins [+] 1 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein eL14 (RPL14) Interacting Protein Interacting Protein Info
UniProt ID
RL14_HUMAN 
Synonyms CAG.ISL.7; CTG.B33; L14; RL14; hRL14
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Reconstituted Complex [8]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) Literature-reported Target Interacting Protein Info
UniProt ID
WWP2_HUMAN 
Synonyms WW domain-containing protein 2; WW domaincontaining protein 2; NEDD4like E3 ubiquitinprotein ligaseWWP2; HECT-type E3 ubiquitin transferase WWP2; Atrophin-1-interacting protein 2; Atrophin1interacting protein 2; AIP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [21]
3 Reconstituted Complex [3]
Other proteins [+] 2 Other proteins +
Interacting Protein Name NEDD4 family-interacting protein 1 (NDFIP1) Interacting Protein Interacting Protein Info
UniProt ID
NFIP1_HUMAN 
Synonyms N4WBP5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Protein-Fragment Complementation Assay [23]
Interacting Protein Name Tubulin beta-2 chain (TUBB2) Interacting Protein Interacting Protein Info
UniProt ID
TBB4B_HUMAN 
Synonyms Beta2; TUBB2; TUBB2C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Reconstituted Complex [8]
References  Top
REF 1 Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell. 2009 Apr 7;15(4):304-14.
REF 2 Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation. Biochem J. 2008 Sep 1;414(2):221-9.
REF 3 WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol. 2011 Jun;13(6):728-33.
REF 4 Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. Genes Dev. 2015 Jan 15;29(2):157-70.
REF 5 Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) is required for the estradiol-dependent increase of phosphatase and tensin homolog (PTEN) protein expression. Endocrinology. 2011 Dec;152(12):4537-49.
REF 6 Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin. J Biol Chem. 2014 Jun 20;289(25):17951-9.
REF 7 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell. 2011 Jan 21;144(2):187-99.
REF 8 Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. Free Radic Biol Med. 2016 Jan;90:24-34.
REF 9 Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. J Biol Chem. 2010 Sep 3;285(36):27900-10.
REF 10 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 11 Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. Proteomics. 2005 Apr;5(5):1250-62.
REF 12 Direct identification of PTEN phosphorylation sites. FEBS Lett. 2002 Sep 25;528(1-3):145-53.
REF 13 PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem. 1999 Jul 16;274(29):20693-703.
REF 14 Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res. 1999 Jan 15;59(2):442-9.
REF 15 Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec;15(12):1486-1494.
REF 16 Down-regulation of USP13 mediates phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis. Respir Res. 2015 Oct 9;16:124.
REF 17 PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress. Antioxid Redox Signal. 2014 Mar 20;20(9):1382-95.
REF 18 USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN. Mol Cell Biochem. 2018 Apr;441(1-2):1-7.
REF 19 PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003 Feb;3(2):117-30.
REF 20 p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN. Cell Death Differ. 2014 Jan;21(1):146-60.
REF 21 The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation. J Biol Chem. 2012 May 4;287(19):15996-6006.
REF 22 Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol. 2012 Jan 9;196(1):29-36.
REF 23 Rab5 and Ndfip1 are involved in Pten ubiquitination and nuclear trafficking. Traffic. 2014 Jul;15(7):749-61.

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