Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | WW domain-containing protein 1 (WWP1) | ||||
| UniProt ID | WWP1_HUMAN | ||||
| Gene Name | WWP1 | ||||
| Gene ID | 11059 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Erbb4 tyrosine kinase receptor (Erbb-4) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Mothers against decapentaplegic homolog 7 (SMAD7) | Target Info | PPI Info | [2] | |
| Interacting Literature-reported Target(s) | Phosphatase and tensin homolog (PTEN) | Target Info | PPI Info | [3] | |
| Protein-tyrosine phosphatase pez (PTPN14) | Target Info | PPI Info | [4] | ||
| Interacting Preclinical Target(s) | Mothers against decapentaplegic homolog 3 (SMAD3) | Target Info | PPI Info | [5] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. Oncogene. 2009 Aug 20;28(33):2948-58. | ||||
| REF 2 | USP11 augments TGF signalling by deubiquitylating ALK5. Open Biol. 2012 Jun;2(6):120063. | ||||
| REF 3 | WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol. 2011 Jun;13(6):728-33. | ||||
| REF 4 | PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1;26(17):1959-71. | ||||
| REF 5 | Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Oncogene. 2004 Sep 9;23(41):6914-23. | ||||
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