| References |
Top |
| REF 1 |
Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways. J Biol Chem. 2004 Jul 16;279(29):30474-9.
|
| REF 2 |
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 2003 May 15;22(10):2453-62.
|
| REF 3 |
AMP-activated protein kinase inhibits TGF--induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300. J Cell Physiol. 2012 Mar;227(3):1081-9.
|
| REF 4 |
Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes. Hepatology. 2010 Sep;52(3):1033-45.
|
| REF 5 |
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 1998 Jul 15;12(14):2114-9.
|
| REF 6 |
Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth fact... Arthritis Rheum. 2007 May;56(5):1694-705.
|
| REF 7 |
The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling. Nucleic Acids Res. 2000 Nov 1;28(21):4291-8.
|
| REF 8 |
Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J Biol Chem. 2005 Oct 21;280(42):35203-8.
|
| REF 9 |
c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem. 1999 Dec 3;274(49):35269-77.
|
| REF 10 |
TRAF4 promotes TGF- receptor signaling and drives breast cancer metastasis. Mol Cell. 2013 Sep 12;51(5):559-72.
|
| REF 11 |
Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. J Cell Biochem. 2008 Oct 1;105(2):596-611.
|
| REF 12 |
Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Oncogene. 2004 Sep 9;23(41):6914-23.
|
| REF 13 |
Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1. Oncotarget. 2016 Jul 18;8(31):50521-50533.
|
| REF 14 |
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):974-9.
|
| REF 15 |
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. J Biol Chem. 2000 Nov 24;275(47):36818-22.
|
| REF 16 |
Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein. Nucleic Acids Res. 2005 Jul 1;33(12):3708-21.
|
| REF 17 |
Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5. Genes Cells. 2004 Feb;9(2):143-51.
|
| REF 18 |
A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGF-mediated breast cancer cell migration and invasion. Breast Cancer Res. 2012 Sep 20;14(5):R127.
|
| REF 19 |
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Biochem J. 2005 Mar 15;386(Pt 3):461-70.
|
| REF 20 |
A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 2011 Jun 15;25(12):1275-88.
|
| REF 21 |
Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF- Pathways. Structure. 2012 Oct 10;20(10):1726-36.
|
| REF 22 |
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell. 2009 Nov 13;36(3):457-68.
|
| REF 23 |
Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor- (TGF-)/Smad Signaling. J Biol Chem. 2016 Jan 1;291(1):382-92.
|
| REF 24 |
TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage. Oncogene. 2005 Mar 31;24(14):2289-97.
|
| REF 25 |
BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses. PLoS One. 2009 Sep 21;4(9):e7091.
|
| REF 26 |
Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program. J Biol Chem. 2008 Jan 11;283(2):1146-55.
|
| REF 27 |
Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF--dependent cancer metastasis. J Clin Invest. 2014 Feb;124(2):564-79.
|
| REF 28 |
An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network. Nat Commun. 2017 Aug 24;8(1):347.
|
| REF 29 |
Functional proteomics mapping of a human signaling pathway. Genome Res. 2004 Jul;14(7):1324-32. Validation Studies
|
| REF 30 |
A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
|
| REF 31 |
Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015 Apr 23;161(3):647-660.
|
| REF 32 |
Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain. Mol Cell Biol. 2007 Sep;27(17):6183-94.
|
| REF 33 |
Identification of three novel Smad binding proteins involved in cell polarity. FEBS Lett. 2003 Mar 27;539(1-3):167-73.
|
| REF 34 |
An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*. J Biol Chem. 2001 Jun 22;276(25):22595-603.
|
| REF 35 |
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. J Biol Chem. 2009 Mar 6;284(10):6109-15.
|
| REF 36 |
Pin1 promotes transforming growth factor-beta-induced migration and invasion. J Biol Chem. 2010 Jan 15;285(3):1754-64.
|
| REF 37 |
Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature. 2004 Jul 8;430(6996):226-31.
|
| REF 38 |
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
|
| REF 39 |
Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science. 2003 Jan 24;299(5606):574-7.
|
| REF 40 |
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization. Sci Signal. 2015 Apr 14;8(372):ra35.
|
| REF 41 |
SMAD3 represses androgen receptor-mediated transcription. Cancer Res. 2001 Mar 1;61(5):2112-8.
|
| REF 42 |
The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3. J Biol Chem. 2002 Jan 11;277(2):1240-8.
|
| REF 43 |
Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4. J Biol Chem. 2002 Nov 15;277(46):43749-56.
|
| REF 44 |
USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol. 2011 Sep 25;13(11):1368-75.
|
| REF 45 |
USP15 stabilizes TGF- receptor I and promotes oncogenesis through the activation of TGF- signaling in glioblastoma. Nat Med. 2012 Feb 19;18(3):429-35.
|
| REF 46 |
Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGF-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis. Sci Rep. 2016 Sep 8;6:33116.
|
| REF 47 |
The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling. Oncogene. 2005 Dec 1;24(54):8080-4.
|
| REF 48 |
Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
|
| REF 49 |
Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell. 2003 May 2;113(3):301-14.
|
| REF 50 |
Differential regulation of the REG-proteasome pathway by p53/TGF- signalling and mutant p53 in cancer cells. Nat Commun. 2013;4:2667.
|
| REF 51 |
A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature. 2002 Aug 8;418(6898):641-6.
|
| REF 52 |
Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. Exp Cell Res. 2005 Jul 1;307(1):231-46.
|
| REF 53 |
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell. 2004 Apr 16;117(2):211-23.
|
| REF 54 |
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 1997 Sep 1;16(17):5353-62.
|
| REF 55 |
Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed. Oncotarget. 2017 Mar 21;8(12):19137-19155.
|
| REF 56 |
Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation. J Biol Chem. 1999 Apr 2;274(14):9431-41.
|
| REF 57 |
Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. Cell. 2002 Nov 1;111(3):357-67.
|
| REF 58 |
Roles of pathway-specific and inhibitory Smads in activin receptor signaling. Mol Endocrinol. 1999 Jan;13(1):15-23.
|
| REF 59 |
Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells. J Biol Chem. 2001 Mar 9;276(10):6983-92.
|
| REF 60 |
Transforming growth factor-1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts. J Biol Chem. 2010 Apr 9;285(15):11638-51.
|
| REF 61 |
Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. J Biol Chem. 2003 Oct 24;278(43):42569-77.
|
| REF 62 |
CBL enhances breast tumor formation by inhibiting tumor suppressive activity of TGF- signaling. Oncogene. 2012 Dec 13;31(50):5123-31.
|
| REF 63 |
Structural basis of heteromeric smad protein assembly in TGF-beta signaling. Mol Cell. 2004 Sep 10;15(5):813-23.
|
| REF 64 |
Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling. J Biol Chem. 2003 Aug 29;278(35):32489-92.
|
| REF 65 |
Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN. J Biol Chem. 2003 Jan 3;278(1):531-6.
|
| REF 66 |
Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcri... J Biol Chem. 2003 Oct 3;278(40):38998-9005.
|
| REF 67 |
Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling. J Biol Chem. 2007 Apr 13;282(15):11365-76.
|
| REF 68 |
The oncoprotein Ski acts as an antagonist of transforming growth factor-beta signaling by suppressing Smad2 phosphorylation. J Biol Chem. 2003 Jul 11;278(28):26249-57.
|
| REF 69 |
Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. Genes Dev. 2002 Aug 1;16(15):1950-63.
|
| REF 70 |
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J Biol Chem. 2005 Jun 24;280(25):24227-37.
|
| REF 71 |
Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation. J Biol Chem. 2009 Sep 4;284(36):23912-24.
|
| REF 72 |
Role of RbBP5 and H3K4me3 in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell. Oncotarget. 2016 Oct 4;7(40):65553-65567.
|
| REF 73 |
Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP. Oncogene. 2005 Jun 2;24(24):3864-74.
|
| REF 74 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
|
| REF 75 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
|
| REF 76 |
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell Biol. 1997 May;17(5):2521-8.
|
| REF 77 |
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. 1998 Aug 27;394(6696):909-13.
|
| REF 78 |
Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation. J Biol Chem. 2000 Sep 29;275(39):30226-31.
|
| REF 79 |
Smads bind directly to the Jun family of AP-1 transcription factors. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4844-9.
|
| REF 80 |
A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads. J Mol Biol. 2004 Feb 6;336(1):9-24.
|
| REF 81 |
Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem. 2001 Oct 19;276(42):38527-35.
|
| REF 82 |
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev. 2001 Nov 1;15(21):2822-36.
|
| REF 83 |
Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science. 1999 Oct 22;286(5440):771-4.
|
| REF 84 |
Smad-Sp1 complexes mediate TGFbeta-induced early transcription of oncogenic Smad7 in pancreatic cancer cells. Carcinogenesis. 2006 Dec;27(12):2392-401.
|
| REF 85 |
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta. J Biol Chem. 2000 Sep 22;275(38):29244-56.
|
| REF 86 |
A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10549-54.
|
| REF 87 |
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. J Biol Chem. 1999 Oct 29;274(44):31577-82.
|
| REF 88 |
Opposite functions of HIF- isoforms in VEGF induction by TGF-1 under non-hypoxic conditions. Oncogene. 2011 Mar 10;30(10):1213-28.
|
| REF 89 |
ATF3, an adaptive-response gene, enhances TGF{beta} signaling and cancer-initiating cell features in breast cancer cells. J Cell Sci. 2010 Oct 15;123(Pt 20):3558-65.
|
| REF 90 |
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell. 2003 Apr;11(4):915-26.
|
| REF 91 |
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. J Biol Chem. 2005 Oct 21;280(42):35477-89.
|
| REF 92 |
SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner. Am J Physiol Cell Physiol. 2014 Aug 1;307(3):C278-87.
|
| REF 93 |
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation. Mol Cell Biol. 2003 Jul;23(13):4494-510.
|
| REF 94 |
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGF signalling and EMT. Oncogene. 2011 May 26;30(21):2451-62.
|
| REF 95 |
Cytoplasmic PML function in TGF-beta signalling. Nature. 2004 Sep 9;431(7005):205-11.
|
| REF 96 |
A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1. EMBO J. 2000 Dec 15;19(24):6759-69.
|
| REF 97 |
Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1. BMC Cell Biol. 2004 May 16;5:20.
|
| REF 98 |
Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription. J Biol Chem. 2001 May 25;276(21):18243-8.
|
