Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) | Literature-reported | Target Info | ||
| UniProt ID | ATF3_HUMAN | ||||
| Gene Name | ATF3 | ||||
| Gene ID | 467 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [1] | |
| Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [2] | ||
| Interacting Discontinued Target(s) | Transcription factor AP-1 (JUN) | Target Info | PPI Info | [3] | |
| Interacting Literature-reported Target(s) | Activating transcription factor 4 (ATF-4) | Target Info | PPI Info | [4] | |
| Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) | Target Info | PPI Info | [3] | ||
| Interacting Preclinical Target(s) | Mothers against decapentaplegic homolog 3 (SMAD3) | Target Info | PPI Info | [5] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | MDM2 mediates ubiquitination and degradation of activating transcription factor 3. J Biol Chem. 2010 Aug 27;285(35):26908-15. | ||||
| REF 2 | ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. J Biol Chem. 2002 Mar 29;277(13):10804-12. | ||||
| REF 3 | Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4. | ||||
| REF 4 | ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2200-5. | ||||
| REF 5 | ATF3, an adaptive-response gene, enhances TGF{beta} signaling and cancer-initiating cell features in breast cancer cells. J Cell Sci. 2010 Oct 15;123(Pt 20):3558-65. | ||||
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