Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Ubiquitin C-terminal hydrolase UCH37 (UCHL5) | Patented-recorded | Target Info | ||
| UniProt ID | UCHL5_HUMAN | ||||
| Gene Name | UCHL5 | ||||
| Gene ID | 51377 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Nitric-oxide synthase inducible (NOS2) | Target Info | PPI Info | [1] | |
| Interacting Patented-recorded Target(s) | Proteasome beta-2 (PS beta-2) | Target Info | PPI Info | [2] | |
| Proteasome beta-5 (PS beta-5) | Target Info | PPI Info | [3] | ||
| Proteasome beta-1 (PS beta-1) | Target Info | PPI Info | [3] | ||
| Ubiquitin C-terminal hydrolase UCH37 (UCHL5) | Target Info | PPI Info | [2] | ||
| Polyubiquitin-C (UBC) | Target Info | PPI Info | [4] | ||
| Interacting Literature-reported Target(s) | Renal carcinoma antigen NY-REN-54 (UBE3A) | Target Info | PPI Info | [5] | |
| Interacting Preclinical Target(s) | Mothers against decapentaplegic homolog 3 (SMAD3) | Target Info | PPI Info | [6] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Nitric Oxide. 2013 Nov 1;34:37-46. | ||||
| REF 2 | Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Mol Cell. 2008 Sep 26;31(6):909-17. | ||||
| REF 3 | Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403. | ||||
| REF 4 | Large-scale analysis of the human ubiquitin-related proteome. Proteomics. 2005 Nov;5(16):4145-51. | ||||
| REF 5 | Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Mol Cell Biol. 2012 Aug;32(15):3095-106. | ||||
| REF 6 | Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGF-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis. Sci Rep. 2016 Sep 8;6:33116. | ||||
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