References |
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Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain. J Biol Chem. 2007 Aug 10;282(32):23184-93.
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Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet. 2006 Aug 15;15(16):2409-20.
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An Interaction Landscape of Ubiquitin Signaling. Mol Cell. 2017 Mar 2;65(5):941-955.e8.
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Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes EMBO J. 2013 Feb 20;32(4):552-65.
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The ubiquitin-proteasome pathway is required for the function of the viral VP16 transcriptional activation domain. FEBS Lett. 2004 Jan 2;556(1-3):19-25.
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Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain. Mol Cell. 2005 Jun 10;18(6):687-98.
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Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry. J Am Chem Soc. 2012 Apr 11;134(14):6416-24.
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Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Biochim Biophys Acta. 2009 Jul;1794(7):1010-6.
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K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin. Mol Cell. 2015 Apr 2;58(1):83-94.
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A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J. 2006 Oct 18;25(20):4877-87.
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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.
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Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b. Oncogene. 2004 Sep 16;23(42):7104-15.
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Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. Oncogene. 2004 Mar 4;23(9):1645-55.
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Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Mol Cell. 2007 Aug 3;27(3):474-85.
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Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015 Apr 13;209(1):111-28.
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Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. PLoS Genet. 2014 Dec 4;10(12):e1004861.
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Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010 Aug;17(8):939-47.
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Ubiquitin binding to A20 ZnF4 is required for modulation of NF-B signaling. Mol Cell. 2010 Nov 24;40(4):548-57.
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Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-B regulation. EMBO J. 2012 Oct 3;31(19):3856-70.
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Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor B (RANK) Signaling Complex Enhances Osteoclastogenesis. J Biol Chem. 2016 Sep 23;291(39):20643-60.
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p62/SQSTM1 enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization. PLoS One. 2013;8(2):e57138.
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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004 Aug 27;15(4):535-48.
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Human KIAA1018/FAN1 localizes to stalled replication forks via its ubiquitin-binding domain. Cell Cycle. 2010 Oct 1;9(19):3977-83.
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Gliotoxin suppresses NF-B activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). ACS Chem Biol. 2015 Mar 20;10(3):675-81.
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IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol. 2008 Nov;10(11):1309-17.
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Structural analysis of the UBA domain of X-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association. PLoS One. 2011;6(12):e28511.
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An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation. PLoS One. 2012;7(11):e48243.
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A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5.
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The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14422-7.
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SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Cell Rep. 2012 Dec 27;2(6):1633-44.
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DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. J Cell Biol. 2012 Apr 16;197(2):179-87.
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Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase. J Biol Chem. 2017 Jun 23;292(25):10398-10413.
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Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation. J Biol Chem. 2018 Jan 12;293(2):588-598.
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ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. J Mol Biol. 2008 Oct 10;382(3):585-600.
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Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone. J Bone Miner Res. 2009 Apr;24(4):632-42.
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Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch. J Biol Chem. 2008 Feb 29;283(9):5427-40.
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Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2018;14(2):347-358.
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Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy. Elife. 2015 Sep 28;4:e08941.
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Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling. J Mol Biol. 2010 Feb 12;396(1):178-94.
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Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone. Calcif Tissue Int. 2006 May;78(5):271-7.
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Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family. Cell. 2014 Jul 31;158(3):549-63.
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p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins. J Biol Chem. 1996 Aug 23;271(34):20235-7.
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Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications. PLoS One. 2013 Sep 11;8(9):e73018.
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Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. Biochemistry. 2008 Aug 26;47(34):8937-49.
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Ubiquitin binds to and regulates a subset of SH3 domains. Mol Cell. 2007 Jan 26;25(2):273-84.
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Conformational and dynamic changes at the interface contribute to ligand binding by ubiquitin. Biochemistry. 2012 Oct 16;51(41):8111-24.
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Interplay of Endosomal pH and Ligand Occupancy in Integrin 51Ubiquitination, Endocytic Sorting, and Cell Migration. Cell Rep. 2015 Oct 20;13(3):599-609.
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PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem. 2010 Jul 30;285(31):23899-907.
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Development of a histone deacetylase 6 inhibitor and its biological effects. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15704-9.
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Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis. Mol Cell Biol. 2011 Aug;31(16):3396-409.
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The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells. Mol Cell. 2010 Jan 15;37(1):79-89.
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Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
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Suramin inhibits cullin-RING E3 ubiquitin ligases. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2011-8.
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NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 2009 Mar 15;23(6):729-39.
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Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science. 2005 Dec 16;310(5755):1821-4.
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Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics. 2009 Sep;8(9):2131-44.
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Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol. 2002 Apr 1;157(1):91-101.
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Ubiquitin mediates the physical and functional interaction between human DNA polymerases and . Nucleic Acids Res. 2013 Feb 1;41(3):1649-60.
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Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr Biol. 2007 Nov 20;17(22):1972-7.
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Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin. PLoS One. 2011;6(12):e29362.
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The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell. 2006 Mar 24;124(6):1197-208.
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Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. EMBO Rep. 2012 Oct;13(10):930-8.
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Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. Mol Cell. 2018 Apr 5;70(1):150-164.e6.
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Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9117-22.
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Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11379-84.
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Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases. Biochemistry. 1989 Oct 17;28(21):8530-6.
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Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem. 2005 Jan 14;280(2):1512-20.
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Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol. 2004 Jan;24(1):84-95.
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Contribution of active site glutamine to rate enhancement in ubiquitin C-terminal hydrolases. FEBS J. 2012 Mar;279(6):1106-18.
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Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome. Sci Rep. 2017 Mar 24;7:45174.
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Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem Biol. 2016 Apr 21;23(4):472-82.
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Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure. 2006 Aug;14(8):1293-302.
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Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: removal of the CAG containing exon. Neurobiol Dis. 2013 Oct;58:49-56.
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Assembly and specific recognition of k29- and k33-linked polyubiquitin. Mol Cell. 2015 Apr 2;58(1):95-109.
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USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538.
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USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms. Cell Chem Biol. 2017 Dec 21;24(12):1501-1512.e5.
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Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP37. J Biol Chem. 2014 Jan 24;289(4):2415-23.
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Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization. Sci Signal. 2015 Apr 14;8(372):ra35.
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Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25. Sci Rep. 2017 Mar 22;7:45037.
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OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 2013 Jul 3;154(1):169-84.
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The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell. 2009 Oct 9;36(1):28-38.
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The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chem Biol. 2011 Dec 23;18(12):1550-61.
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Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol. 2013 Oct 14;203(1):115-28.
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Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2. J Biol Chem. 2013 Mar 8;288(10):6890-902.
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A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat Cell Biol. 2006 Aug;8(8):834-42.
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The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. J Biol Chem. 2009 May 8;284(19):12622-32.
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Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14782-7.
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A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
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Ubiquitin recognition by the human TSG101 protein. Mol Cell. 2004 Mar 26;13(6):783-9.
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Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J. 2007 Jul 25;26(14):3451-62.
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Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol. 2006 Feb;8(2):163-9.
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NEMO oligomerization and its ubiquitin-binding properties. Biochem J. 2009 Jun 26;421(2):243-51.
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Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr Biol. 2007 Aug 21;17(16):1438-43.
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SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity. Biochim Biophys Acta. 2015 Jan;1853(1):136-43.
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Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene. 2008 Jun 12;27(26):3739-45.
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Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat Cell Biol. 2002 May;4(5):394-8.
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Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J Biol Chem. 2006 Aug 4;281(31):21640-51.
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USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response. Nat Commun. 2017 Jun 1;8:15752.
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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science. 2007 May 25;316(5828):1198-202.
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Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein. J Biol Chem. 2018 Jan 5;293(1):132-147.
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GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination. J Biol Chem. 2004 Feb 20;279(8):7105-11.
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Ubiquitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradation. PLoS One. 2012;7(8):e40361.
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SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor. J Biol Chem. 2009 Dec 25;284(52):36062-76.
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Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1. Mol Cell Biol. 2014 Sep;34(17):3214-28.
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Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes. J Biol Chem. 2011 May 13;286(19):16726-33.
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Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK kinase-mediated antiviral response. Immunity. 2014 Jun 19;40(6):880-95.
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Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter. Mol Cell Biol. 2009 Jun;29(12):3401-12.
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Spartan/C1orf124 is important to prevent UV-induced mutagenesis. Cell Cycle. 2012 Sep 15;11(18):3395-402.
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DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. Nat Struct Mol Biol. 2012 Nov;19(11):1084-92.
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