Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Histone deacetylase 6 (HDAC6) | Clinical trial | Target Info | ||
| UniProt ID | HDAC6_HUMAN | ||||
| Gene Name | HDAC6 | ||||
| Gene ID | 10013 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
| Heat shock protein 90 alpha (HSP90A) | Target Info | PPI Info | [2] | ||
| Protein kinase C alpha (PRKCA) | Target Info | PPI Info | [3] | ||
| Interacting Clinical trial Target(s) | Histone deacetylase 6 (HDAC6) | Target Info | PPI Info | [2] | |
| Endoplasmic reticulum chaperone BiP (HSPA5) | Target Info | PPI Info | [2] | ||
| Histone acetyltransferase p300 (EP300) | Target Info | PPI Info | [5] | ||
| Interacting Patented-recorded Target(s) | Polyubiquitin-C (UBC) | Target Info | PPI Info | [4] | |
| Interacting Literature-reported Target(s) | DNA mismatch repair protein MSH2 (MSH2) | Target Info | PPI Info | [2] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem. 2010 Apr 9;285(15):11219-26. | ||||
| REF 2 | A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. Cell Death Differ. 2013 Oct;20(10):1306-16. | ||||
| REF 3 | PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and -catenin. EMBO J. 2011 Sep 27;30(23):4838-49. | ||||
| REF 4 | Development of a histone deacetylase 6 inhibitor and its biological effects. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15704-9. | ||||
| REF 5 | Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity. Biochem Biophys Res Commun. 2009 May 22;383(1):88-92. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.