Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T18477 | Target Info | |||
Target Name | Heat shock protein 90 alpha (HSP90A) | ||||
Synonyms | Renal carcinoma antigen NY-REN-38; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; LAP-2; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSPCA; HSPC1; HSP90A; HSP86; HSP 86 | ||||
Target Type | Successful Target | ||||
Gene Name | HSP90AA1 | ||||
Biochemical Class | Heat shock protein | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acyltransferases | [+] 1 Acyltransferases | + | |||
Interacting Protein Name | E3 ubiquitin-protein ligase CHIP (STUB1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1 | ||||
Evidence Score (E-score) | 11 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-Western | [3] | |||
4 | Affinity Capture-Western | [4] | |||
5 | Affinity Capture-Western | [5] | |||
6 | Affinity Capture-Western | [6] | |||
7 | Protein-peptide | [7] | |||
8 | Reconstituted Complex | [8] | |||
9 | Reconstituted Complex | [9] | |||
10 | Reconstituted Complex | [10] | |||
11 | Reconstituted Complex | [11] | |||
Alpha-type channels | [+] 1 Alpha-type channels | + | |||
Interacting Target Name | Voltage-gated potassium channel Kv11.1 (KCNH2) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; hERG-1; hERG1; HERG K+ channel; H-ERG; HERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; ERG-1; Erg1; ERG; Eag related protein 1; Eag homolog | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [12] | |||
2 | Affinity Capture-Western | [13] | |||
Carbon-nitrogen hydrolases | [+] 1 Carbon-nitrogen hydrolases | + | |||
Interacting Target Name | Histone deacetylase 6 (HDAC6) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | KIAA0901; JM21; HD6 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [14] | |||
2 | Affinity Capture-Western | [15] | |||
3 | Biochemical Activity | [16] | |||
Cell division cycle proteins | [+] 2 Cell division cycle proteins | + | |||
Interacting Target Name | Hsp90 co-chaperone Cdc37 (CDC37) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A | ||||
Evidence Score (E-score) | 12 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [17] | |||
3 | Affinity Capture-MS | [2] | |||
4 | Affinity Capture-Western | [18] | |||
5 | Affinity Capture-Western | [19] | |||
6 | Affinity Capture-Western | [20] | |||
7 | Affinity Capture-Western | [21] | |||
8 | Affinity Capture-Western | [6] | |||
9 | Affinity Capture-Western | [22] | |||
10 | Affinity Capture-Western | [23] | |||
11 | Co-crystal Structure | [24] | |||
12 | Reconstituted Complex | [25] | |||
Interacting Protein Name | Hsp90 co-chaperone Cdc37-like 1 (CDC37L1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CDC37B; HARC | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [17] | |||
3 | Affinity Capture-Western | [26] | |||
Ester hydrolases | [+] 1 Ester hydrolases | + | |||
Interacting Target Name | Serine/threonine-protein phosphatase 5 (PPP5C) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein phosphatase T; PPT protein; PP-T; PPP5; PP5 | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [4] | |||
3 | Affinity Capture-Western | [6] | |||
4 | Affinity Capture-Western | [27] | |||
5 | Reconstituted Complex | [28] | |||
Heat shock proteins | [+] 5 Heat shock proteins | + | |||
Interacting Target Name | Heat shock protein 90 beta (HSP90B) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HSP84; HSP 84; Heat shock 84 kDa | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [17] | |||
3 | Affinity Capture-MS | [2] | |||
4 | Co-fractionation | [29] | |||
5 | Co-fractionation | [30] | |||
Interacting Protein Name | Heat shock 70 kDa protein 1A (HSPA1A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HEL.S.103; HSP70.1; HSP70.1A; HSP70I; HSP72; HSPA1 | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [31] | |||
3 | Affinity Capture-Western | [26] | |||
4 | Reconstituted Complex | [32] | |||
5 | Yeast two hybrid | [33] | |||
Interacting Target Name | Lipopolysaccharide-associated protein 1 (HSPA8) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-Western | [34] | |||
4 | Co-fractionation | [30] | |||
Interacting Protein Name | Heat shock 70 kDa protein 4 (HSPA4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-Western | [35] | |||
3 | Co-fractionation | [30] | |||
Interacting Protein Name | Heat shock 70 kDa protein 1B (HSPA1B) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HSP70.1B; HSP70.2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-Western | [6] | |||
Hydrolysis-driven transporters | [+] 1 Hydrolysis-driven transporters | + | |||
Interacting Target Name | cAMP-dependent chloride channel (CFTR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Cystic fibrosis transmembrane conductance regulator; Channel conductancecontrolling ATPase; cAMP-dependent chloride channel; cAMPdependent chloride channel; ATP-binding cassette sub-family C member 7; ATPbinding cassette subfamily C member 7; ABCC7 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [36] | |||
2 | Affinity Capture-Western | [36] | |||
Isomerases | [+] 5 Isomerases | + | |||
Interacting Protein Name | Prostaglandin E synthase 3 (PTGES3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | P23; TEBP; cPGES | ||||
Evidence Score (E-score) | 20 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [18] | |||
3 | Affinity Capture-Western | [37] | |||
4 | Affinity Capture-Western | [4] | |||
5 | Affinity Capture-Western | [16] | |||
6 | Affinity Capture-Western | [19] | |||
7 | Affinity Capture-Western | [21] | |||
8 | Affinity Capture-Western | [6] | |||
9 | Affinity Capture-Western | [23] | |||
10 | Affinity Capture-Western | [27] | |||
11 | Affinity Capture-Western | [34] | |||
12 | Affinity Capture-Western | [38] | |||
13 | Affinity Capture-Western | [39] | |||
14 | Affinity Capture-Western | [40] | |||
15 | Reconstituted Complex | [41] | |||
16 | Reconstituted Complex | [27] | |||
17 | Reconstituted Complex | [42] | |||
18 | Reconstituted Complex | [43] | |||
19 | Yeast two hybrid | [44] | |||
20 | Yeast two hybrid | [45] | |||
Interacting Target Name | FK506-binding protein 4 (FKBP4) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PPIase FKBP4; Peptidyl-prolyl cis-trans isomerase FKBP4; P59 protein; p59; Immunophilin FKBP52; HSP-binding immunophilin; HSP binding immunophilin; HBI; FKBP59; FKBP52 protein; FKBP-52; FKBP52; FKBP-4; 59 kDa immunophilin; 52 kDa FKBP; 52 kDa FK506-binding protein; 52 kDa FK506 binding protein | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-Western | [4] | |||
4 | Co-fractionation | [29] | |||
5 | Reconstituted Complex | [46] | |||
Interacting Target Name | FK506-binding protein 5 (FKBP5) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PPIase FKBP5; Peptidyl-prolyl cis-trans isomerase FKBP5; HSP90-binding immunophilin; FKBP54; FKBP-51; FKBP51; FKBP-5; FF1 antigen; Androgen-regulated protein 6; AIG6; 54 kDa progesterone receptor-associated immunophilin; 51 kDa FKBP; 51 kDa FK506-binding protein | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-Western | [4] | |||
4 | Affinity Capture-Western | [37] | |||
5 | Co-fractionation | [29] | |||
Interacting Target Name | Rotamase D (PPID) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PPIase D; Peptidylprolyl isomerase D; Peptidyl-prolyl cis-trans isomerase D; CYPD; CYP-40; CYP40; Cyclophilin-related protein; Cyclophilin-40; 40 kDa peptidyl-prolyl cis-trans isomerase | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [47] | |||
2 | Co-purification | [48] | |||
3 | Reconstituted Complex | [47] | |||
Interacting Protein Name | Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | FKBP38; FKBPr38 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-Western | [49] | |||
3 | Affinity Capture-Western | [50] | |||
Kinases | [+] 30 Kinases | + | |||
Interacting Target Name | Proto-oncogene c-RAF (c-RAF) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf | ||||
Evidence Score (E-score) | 7 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [18] | |||
3 | Affinity Capture-Western | [20] | |||
4 | Affinity Capture-Western | [52] | |||
5 | Affinity Capture-Western | [53] | |||
6 | Affinity Capture-Western | [54] | |||
7 | Affinity Capture-Western | [55] | |||
Interacting Target Name | Erbb2 tyrosine kinase receptor (HER2) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tyrosine kinase-type cell surface receptor HER2; Tyrosine kinase receptor ErbB2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; P185erbB2; NGL; NEU proto-oncogene; NEU; MLN19; MLN 19; Metastatic lymph node gene 19 protein; HER2/neu; HER2 (erbB2/neu); HER-2; Erb2; Epidermal growth factor receptor 2; C-erbB-2 oncoprotein; C-erbB-2; CD340 | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [56] | |||
3 | Affinity Capture-Western | [18] | |||
4 | Affinity Capture-Western | [19] | |||
5 | Affinity Capture-Western | [21] | |||
6 | Affinity Capture-Western | [57] | |||
Interacting Target Name | RAC-alpha serine/threonine-protein kinase (AKT1) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [58] | |||
2 | Affinity Capture-Western | [59] | |||
3 | Affinity Capture-Western | [60] | |||
4 | Affinity Capture-Western | [61] | |||
5 | Co-localization | [59] | |||
Interacting Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [62] | |||
2 | Affinity Capture-Western | [63] | |||
3 | Protein-Fragment Complementation Assay | [64] | |||
4 | Yeast two hybrid | [65] | |||
Interacting Target Name | Cyclin-dependent kinase 4 (CDK4) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PSK-J3; Cell division protein kinase 4 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [19] | |||
3 | Affinity Capture-Western | [21] | |||
4 | Affinity Capture-Western | [52] | |||
Interacting Target Name | Tyrosine-protein kinase ABL1 (ABL) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [66] | |||
3 | Affinity Capture-Western | [67] | |||
Interacting Target Name | Telomerase reverse transcriptase (TERT) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TRT; TP2; Telomerase-associated protein 2; Telomerase catalytic subunit; TCS1; HEST2; EST2 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [58] | |||
2 | Affinity Capture-Western | [68] | |||
3 | Reconstituted Complex | [69] | |||
Interacting Target Name | TGF-beta receptor type I (TGFBR1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; TbetaR-I; TbetaRI; SKR4; Serine/threonine-protein kinase receptor R4; ALK-5; ALK5; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [70] | |||
2 | Affinity Capture-Western | [71] | |||
3 | Reconstituted Complex | [70] | |||
Interacting Target Name | TGF-beta receptor type II (TGFBR2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Transforminggrowth factor-beta receptor type II; Transforming growth factor-beta receptor type II; TGFR-2; TGF-beta type II receptor; TGF-beta receptor type-2; TbetaR-II | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [70] | |||
2 | Affinity Capture-Western | [71] | |||
3 | Reconstituted Complex | [70] | |||
Interacting Target Name | Leucine-rich repeat kinase 2 (LRRK2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PARK8; LRRK2 S935 phosphorylation; LRRK2 G2019S mutation; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [72] | |||
2 | Affinity Capture-Western | [73] | |||
3 | Biochemical Activity | [74] | |||
Interacting Target Name | Protein kinase C zeta (PRKCZ) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein kinase C zeta type; PKC2; NPKC-zeta | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [75] | |||
2 | Affinity Capture-Western | [51] | |||
3 | Yeast two hybrid | [76] | |||
Interacting Target Name | Activated CDC42 kinase 1 (ACK-1) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tyrosine kinase non-receptor protein 2; Tyrosine kinase nonreceptor protein 2; ACK-1; ACK1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [77] | |||
3 | Affinity Capture-Western | [78] | |||
Interacting Target Name | Tropomyosin-related kinase A (TrkA) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; NGF-trk receptor type A; Neurotrophic tyrosine kinase receptor type 1; MTC; High affinity nerve growth factor receptor; gp140trk | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [79] | |||
2 | Affinity Capture-Western | [80] | |||
Interacting Target Name | Fyn tyrosine protein kinase (FYN) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Fyn Protooncogene Syn; Fyn p59-Fyn | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [81] | |||
2 | Affinity Capture-Western | [82] | |||
Interacting Target Name | Tyrosine-protein kinase UFO (AXL) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [83] | |||
Interacting Target Name | Glycogen synthase kinase-3 beta (GSK-3B) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Serine/threonine-protein kinase GSK3B; GSK-3 beta | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [84] | |||
2 | Biochemical Activity | [5] | |||
Interacting Target Name | Aurora kinase B (AURKB) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | STK5; STK12; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora/IPL1-related kinase 2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK-2; ARK2; AIRK2; AIM-1; AIM1; AIK2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [81] | |||
2 | Affinity Capture-Western | [51] | |||
Interacting Target Name | Checkpoint kinase-1 (CHK1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Chk1; Cell cycle checkpoint kinase | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [85] | |||
Interacting Target Name | Casein kinase II alpha (CSNK2A1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [27] | |||
2 | Reconstituted Complex | [86] | |||
Interacting Target Name | Serine/threonine-protein kinase pim-1 (PIM1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PIM; Pim-1 proto-oncogene, serine/threonine kinase | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [87] | |||
2 | Affinity Capture-Western | [87] | |||
Interacting Target Name | NF-kappa-B-activating kinase (TBK1) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [88] | |||
Interacting Target Name | Mixed lineage kinase 3 (MAP3K11) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Src-homology 3 domain-containing proline-rich kinase; SPRK; SH3 domain-containing proline-rich kinase; PTK1; Protein-tyrosine kinase PTK1; MLK3; Mixed-lineage protein kinase 3; Mitogen-activated protein kinase kinase kinase 11 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [89] | |||
2 | Affinity Capture-Western | [89] | |||
Interacting Target Name | Tyrosine-protein kinase EIF2AK2 (p68) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Proteinkinase RNA-activated; Protein kinase RNA-activated; Protein kinase R; PRKR; PKR; p68 kinase; P1/eIF-2A protein kinase; Interferon-inducible RNA-dependent protein kinase; Interferon-induced, double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [90] | |||
Interacting Target Name | Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [91] | |||
Interacting Target Name | Casein kinase I alpha (CSNK1A1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CKI-alpha; CK1; Casein kinase I isoform alpha | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-MS | [1] | |||
Interacting Target Name | Serine/threonine-protein kinase NIK (MAP3K14) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | NIK; NF-kappa-beta-inducing kinase; Mitogen-activated protein kinase kinase kinase 14; HsNIK | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [92] | |||
Interacting Target Name | Myosin light chain kinase 2 (MYLK2) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MYLK2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-MS | [1] | |||
Interacting Target Name | Fused homolog (STK36) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Serine/threonine-protein kinase 36; KIAA1278 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [93] | |||
2 | Affinity Capture-Western | [94] | |||
Interacting Protein Name | RNA polymerase II subunit E (POLR2E) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RPABC1; RPB5; XAP4; hRPB25; hsRPB5 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
Interacting Target Name | Cyclin-dependent kinase 9 (CDK9) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2-related kinase; CDC2L4; C-2K | ||||
Evidence Score (E-score) | 1 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [81] | |||
Nuclear hormone receptors | [+] 5 Nuclear hormone receptors | + | |||
Interacting Target Name | Glucocorticoid receptor (NR3C1) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A | ||||
Evidence Score (E-score) | 12 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [95] | |||
3 | Affinity Capture-Western | [96] | |||
4 | Affinity Capture-Western | [16] | |||
5 | Affinity Capture-Western | [20] | |||
6 | Affinity Capture-Western | [21] | |||
7 | Affinity Capture-Western | [52] | |||
8 | Affinity Capture-Western | [97] | |||
9 | Reconstituted Complex | [32] | |||
10 | Reconstituted Complex | [98] | |||
11 | Reconstituted Complex | [28] | |||
12 | Reconstituted Complex | [99] | |||
Interacting Target Name | Estrogen receptor (ESR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [53] | |||
3 | Affinity Capture-Western | [100] | |||
4 | Affinity Capture-Western | [101] | |||
Interacting Target Name | Androgen receptor (AR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [102] | |||
2 | Reconstituted Complex | [103] | |||
3 | Yeast two hybrid | [104] | |||
Interacting Target Name | Orphan nuclear receptor NR1I3 (NR1I3) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Orphan nuclear receptor MB67; Orphan nuclear receptor CAR; Nuclear receptor subfamily 1 group I member 3; Nuclear receptor CAR; Constitutive androstane receptor; Constitutive active response; Constitutive activator of retinoid response; CAR | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [105] | |||
Interacting Target Name | Peroxisome proliferator-activated receptor delta (PPARD) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PPAR-delta; PPARdelta; PPAR-beta; PPARB; Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Yeast two hybrid | [101] | |||
One-carbon transferases | [+] 1 One-carbon transferases | + | |||
Interacting Target Name | SET and MYND domain-containing protein 2 (SMYD2) | Preclinical Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | N-lysine methyltransferase SMYD2; Nlysine methyltransferase SMYD2; Lysine N-methyltransferase 3C; Lysine Nmethyltransferase 3C; KMT3C; HSKM-B; HSKMB; Histone methyltransferase SMYD2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [106] | |||
2 | Biochemical Activity | [107] | |||
Oxidoreductases | [+] 4 Oxidoreductases | + | |||
Interacting Target Name | Nitric-oxide synthase endothelial (NOS3) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | NOSIII; NOS,type III; NOS type III; Nitric oxide synthase, endothelial; ENOS; Endothelial NOS; Endothelial nitric oxide synthase; EC-NOS; Constitutive NOS; CNOS | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [108] | |||
2 | Affinity Capture-Western | [109] | |||
3 | Affinity Capture-Western | [110] | |||
4 | Affinity Capture-Western | [111] | |||
5 | Reconstituted Complex | [110] | |||
6 | Reconstituted Complex | [112] | |||
Interacting Target Name | Nitric-oxide synthase inducible (NOS2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Peptidyl-cysteine S-nitrosylase NOS2; NOS2A; NOS, type II; NOS type II; Nitric oxide synthase, inducible; INOS; Inducible NOS; Inducible NO synthase; Inducible nitric oxide synthase; HEP-NOS; Hepatocyte NOS | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [113] | |||
2 | Affinity Capture-Western | [114] | |||
Interacting Target Name | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Peptidyl-cysteine S-nitrosylase GAPDH; OK/SW-cl.12; GAPD; D-glyceraldehyde-3-phosphate dehydrogenase; CDABP0047 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [31] | |||
2 | Co-fractionation | [30] | |||
Interacting Target Name | HIF-prolyl hydroxylase 2 (HPH-2) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | SM-20; SM20; Prolyl hydroxylase domain-containing protein 2; Prolyl hydroxylase domaincontaining protein 2; PNAS-137; PNAS-118; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; Hypoxiainducible factor prolyl hydroxylase 2; HPH2; HIFprolyl hydroxylase 2; HIF-PH2; HIFPH2; Egl nine homolog 1; C1orf12 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [115] | |||
2 | Reconstituted Complex | [116] | |||
Peptidases | [+] 2 Peptidases | + | |||
Interacting Protein Name | Ubiquitin carboxyl-terminal hydrolase 19 (USP19) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ZMYND9 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [117] | |||
3 | Affinity Capture-Western | [118] | |||
Interacting Target Name | Ubiquitin thioesterase L1 (UCHL1) | Preclinical Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | UCH-L1; Ubiquitin thiolesterase L1; Ubiquitin carboxy-terminal hydrolase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [119] | |||
2 | Reconstituted Complex | [120] | |||
Pore-forming toxins | [+] 1 Pore-forming toxins | + | |||
Interacting Target Name | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [51] | |||
2 | Affinity Capture-Western | [121] | |||
3 | Biochemical Activity | [11] | |||
4 | Reconstituted Complex | [122] | |||
Ribosomal proteins | [+] 4 Ribosomal proteins | + | |||
Interacting Protein Name | Large ribosomal subunit protein uL18 (RPL5) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DBA6; L5; PPP1R135 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [31] | |||
2 | Co-fractionation | [123] | |||
Interacting Protein Name | Large ribosomal subunit protein uL30 (RPL7) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | L7; humL7.1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [31] | |||
2 | Co-fractionation | [123] | |||
Interacting Protein Name | Small ribosomal subunit protein eS1 (RPS3A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | FTE1; MFTL; S3A | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [31] | |||
2 | Affinity Capture-Western | [124] | |||
Interacting Protein Name | Small ribosomal subunit protein eS6 (RPS6) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | S6 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [31] | |||
2 | Affinity Capture-Western | [35] | |||
Transcription regulators | [+] 6 Transcription regulators | + | |||
Interacting Target Name | Hypoxia-inducible factor 1 alpha (HIF-1A) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein | ||||
Evidence Score (E-score) | 10 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [125] | |||
2 | Affinity Capture-Western | [126] | |||
3 | Affinity Capture-Western | [127] | |||
4 | Affinity Capture-Western | [128] | |||
5 | Affinity Capture-Western | [129] | |||
6 | Affinity Capture-Western | [130] | |||
7 | Affinity Capture-Western | [131] | |||
8 | Reconstituted Complex | [132] | |||
9 | Reconstituted Complex | [133] | |||
10 | Yeast two hybrid | [130] | |||
Interacting Target Name | Heat shock protein 70 (HSP70) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Molecular chaperone Hsp70; HSTF1; HSTF 1; HSP70; HSF 1; Heat shock transcription factor 1; Heat shock factor protein 1; Heat shock 70 kDa protein; Chaperone protein dnaK | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [134] | |||
2 | Affinity Capture-Western | [130] | |||
3 | Affinity Capture-Western | [135] | |||
4 | Affinity Capture-Western | [136] | |||
5 | Affinity Capture-Western | [137] | |||
6 | Yeast two hybrid | [130] | |||
Interacting Target Name | Aryl hydrocarbon receptor (AHR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Class E basic helix-loop-helix protein 76; Class E basic helixloophelix protein 76; bHLHe76; AhR; Ah receptor | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [138] | |||
2 | Reconstituted Complex | [139] | |||
3 | Reconstituted Complex | [138] | |||
Interacting Target Name | Interferon regulatory factor 3 (IRF3) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | IRF-3 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [88] | |||
2 | Reconstituted Complex | [140] | |||
3 | Yeast two hybrid | [88] | |||
Interacting Target Name | Transcription factor Sp1 (SP1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TSFP1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [141] | |||
2 | Reconstituted Complex | [141] | |||
Interacting Target Name | Transcription factor AP-1 (JUN) | Discontinued Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Reconstituted Complex | [142] | |||
2 | Yeast two hybrid | [76] | |||
Ubiquitin related proteins | [+] 1 Ubiquitin related proteins | + | |||
Interacting Target Name | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [143] | |||
2 | Affinity Capture-Western | [144] | |||
3 | Co-purification | [11] | |||
4 | Protein-peptide | [145] | |||
5 | Reconstituted Complex | [11] | |||
Other proteins | [+] 14 Other proteins | + | |||
Interacting Protein Name | Stress-induced-phosphoprotein 1 (STIP1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HEL.S.94n; HOP; IEF.SSP.3521; P60; STI1; STI1L | ||||
Evidence Score (E-score) | 14 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [17] | |||
3 | Affinity Capture-MS | [2] | |||
4 | Affinity Capture-Western | [18] | |||
5 | Affinity Capture-Western | [19] | |||
6 | Affinity Capture-Western | [20] | |||
7 | Affinity Capture-Western | [21] | |||
8 | Affinity Capture-Western | [6] | |||
9 | Affinity Capture-Western | [23] | |||
10 | Affinity Capture-Western | [26] | |||
11 | Affinity Capture-Western | [39] | |||
12 | Reconstituted Complex | [146] | |||
13 | Reconstituted Complex | [147] | |||
14 | Reconstituted Complex | [148] | |||
Interacting Protein Name | Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | AHA1; C14orf3; p38 | ||||
Evidence Score (E-score) | 13 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [149] | |||
3 | Affinity Capture-Western | [18] | |||
4 | Affinity Capture-Western | [19] | |||
5 | Affinity Capture-Western | [20] | |||
6 | Affinity Capture-Western | [21] | |||
7 | Affinity Capture-Western | [6] | |||
8 | Affinity Capture-Western | [22] | |||
9 | Co-fractionation | [30] | |||
10 | Reconstituted Complex | [149] | |||
11 | Reconstituted Complex | [25] | |||
12 | Reconstituted Complex | [150] | |||
13 | Yeast two hybrid | [149] | |||
Interacting Target Name | Suppressor of G2 allele of SKP1 homolog (Sgt1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein SGT1 homolog; Protein 40-6-3 | ||||
Evidence Score (E-score) | 5 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [151] | |||
3 | Affinity Capture-Western | [152] | |||
4 | Co-localization | [152] | |||
5 | Reconstituted Complex | [10] | |||
Interacting Protein Name | Calcyclin-binding protein (CACYBP) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | GIG5; S100A6BP; SIP | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [152] | |||
3 | Co-localization | [152] | |||
4 | Reconstituted Complex | [152] | |||
Interacting Protein Name | DnaJ homolog subfamily C member 7 (DNAJC7) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DJ11; DJC7; TPR2; TTC2 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [4] | |||
3 | Yeast two hybrid | [33] | |||
Interacting Protein Name | RNA polymerase II-associated protein 3 (RPAP3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Reconstituted Complex | [153] | |||
Interacting Target Name | HCLS1-associated protein X-1 (HAX1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HSP1BP-1; HS1BP1; HS1-binding protein 1; HS1-associating protein X-1; HAX-1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [59] | |||
2 | Co-localization | [59] | |||
Interacting Protein Name | AH receptor-interacting protein (AIP) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ARA9; FKBP16; FKBP37; SMTPHN; XAP.2; XAP2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [4] | |||
2 | Reconstituted Complex | [139] | |||
Interacting Protein Name | DnaJ homolog subfamily A member 2 (DNAJA2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4; PRO3015; RDJ2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Co-fractionation | [30] | |||
Interacting Protein Name | Tubulin alpha-1A chain (TUBA1A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | B.ALPHA.1; LIS3; TUBA3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Affinity Capture-Western | [134] | |||
Interacting Protein Name | Mitochondrial import receptor subunit TOM34 (TOMM34) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HTOM34P; TOM34; URCC3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
Interacting Protein Name | Tropomyosin alpha-3 chain (TPM3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CAPM1; CFTD; HEL.189; HEL.S.82p; NEM1; OK/SW.cl.5; TM.5; TM3; TM30; TM30nm; TM5; TPMsk3; TRK; hscp30 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [31] | |||
2 | Co-fractionation | [29] | |||
Interacting Protein Name | Tetratricopeptide repeat protein 4 (TTC4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
Interacting Protein Name | Protein unc-45 homolog A (UNC45A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | GC.UNC45; GCUNC.45; GCUNC45; IRO039700; SMAP.1; SMAP1; UNC.45A | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Yeast two hybrid | [154] |
References | Top | ||||
---|---|---|---|---|---|
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REF 2 | Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. Proteomics. 2011 Apr;11(8):1508-16. | ||||
REF 3 | CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. Hum Mol Genet. 2007 Apr 1;16(7):848-64. | ||||
REF 4 | Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors. PLoS One. 2010 Jul 22;5(7):e11717. | ||||
REF 5 | C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances. Oncogene. 2013 Jun 20;32(25):3101-10. | ||||
REF 6 | The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nat Commun. 2016 Jun 29;7:12037. | ||||
REF 7 | Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics. 2006 Feb;5(2):234-44. | ||||
REF 8 | Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol Cell. 2005 Nov 23;20(4):525-38. | ||||
REF 9 | Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP). J Biol Chem. 2011 May 6;286(18):15883-94. | ||||
REF 10 | Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. EMBO J. 2008 Oct 22;27(20):2789-98. | ||||
REF 11 | Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein. J Mol Biol. 2004 Mar 12;337(1):129-45. | ||||
REF 12 | Co-chaperone FKBP38 promotes HERG trafficking. J Biol Chem. 2007 Aug 10;282(32):23509-16. | ||||
REF 13 | Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins. Cardiovasc Res. 2013 Dec 1;100(3):520-8. | ||||
REF 14 | A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. Cell Death Differ. 2013 Oct;20(10):1306-16. | ||||
REF 15 | HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. J Biol Chem. 2009 Mar 20;284(12):7436-45. | ||||
REF 16 | HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell. 2005 May 27;18(5):601-7. | ||||
REF 17 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23. | ||||
REF 18 | Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mol Cell. 2010 Feb 12;37(3):333-43. | ||||
REF 19 | Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2937-42. | ||||
REF 20 | Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors. Mol Cell. 2014 Jan 23;53(2):317-29. | ||||
REF 21 | Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors. Cell Rep. 2016 Feb 2;14(4):872-884. | ||||
REF 22 | Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast. Biochim Biophys Acta. 2015 Feb;1853(2):445-52. | ||||
REF 23 | Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo. Int J Cancer. 2013 Feb 1;132(3):695-706. | ||||
REF 24 | The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell. 2004 Jan 9;116(1):87-98. | ||||
REF 25 | Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012 Jun;1823(6):1092-101. | ||||
REF 26 | Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37. J Biol Chem. 2001 Aug 17;276(33):30971-9. | ||||
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