Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T18477 Target Info
Target Name Heat shock protein 90 alpha (HSP90A)
Synonyms Renal carcinoma antigen NY-REN-38; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; LAP-2; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSPCA; HSPC1; HSP90A; HSP86; HSP 86
Target Type Successful Target
Gene Name HSP90AA1
Biochemical Class Heat shock protein
UniProt ID
HS90A_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Protein-peptide [7]
8 Reconstituted Complex [8]
9 Reconstituted Complex [9]
10 Reconstituted Complex [10]
11 Reconstituted Complex [11]
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Target Name Voltage-gated potassium channel Kv11.1 (KCNH2) Successful Target Interacting Protein Info
UniProt ID
KCNH2_HUMAN 
Synonyms Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; hERG-1; hERG1; HERG K+ channel; H-ERG; HERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; ERG-1; Erg1; ERG; Eag related protein 1; Eag homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [13]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 6 (HDAC6) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC6_HUMAN 
Synonyms KIAA0901; JM21; HD6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [15]
3 Biochemical Activity [16]
Cell division cycle proteins [+] 2 Cell division cycle proteins +
Interacting Target Name Hsp90 co-chaperone Cdc37 (CDC37) Literature-reported Target Interacting Protein Info
UniProt ID
CDC37_HUMAN 
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [17]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [19]
6 Affinity Capture-Western [20]
7 Affinity Capture-Western [21]
8 Affinity Capture-Western [6]
9 Affinity Capture-Western [22]
10 Affinity Capture-Western [23]
11 Co-crystal Structure [24]
12 Reconstituted Complex [25]
Interacting Protein Name Hsp90 co-chaperone Cdc37-like 1 (CDC37L1) Interacting Protein Interacting Protein Info
UniProt ID
CD37L_HUMAN 
Synonyms CDC37B; HARC
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [17]
3 Affinity Capture-Western [26]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Serine/threonine-protein phosphatase 5 (PPP5C) Patented-recorded Target Interacting Protein Info
UniProt ID
PPP5_HUMAN 
Synonyms Protein phosphatase T; PPT protein; PP-T; PPP5; PP5
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [6]
4 Affinity Capture-Western [27]
5 Reconstituted Complex [28]
Heat shock proteins [+] 5 Heat shock proteins +
Interacting Target Name Heat shock protein 90 beta (HSP90B) Clinical trial Target Interacting Protein Info
UniProt ID
HS90B_HUMAN 
Synonyms HSP84; HSP 84; Heat shock 84 kDa
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [17]
3 Affinity Capture-MS [2]
4 Co-fractionation [29]
5 Co-fractionation [30]
Interacting Protein Name Heat shock 70 kDa protein 1A (HSPA1A) Interacting Protein Interacting Protein Info
UniProt ID
HS71A_HUMAN 
Synonyms HEL.S.103; HSP70.1; HSP70.1A; HSP70I; HSP72; HSPA1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [31]
3 Affinity Capture-Western [26]
4 Reconstituted Complex [32]
5 Yeast two hybrid [33]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [34]
4 Co-fractionation [30]
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [35]
3 Co-fractionation [30]
Interacting Protein Name Heat shock 70 kDa protein 1B (HSPA1B) Interacting Protein Interacting Protein Info
UniProt ID
HS71B_HUMAN 
Synonyms HSP70.1B; HSP70.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [6]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Target Name cAMP-dependent chloride channel (CFTR) Successful Target Interacting Protein Info
UniProt ID
CFTR_HUMAN 
Synonyms Cystic fibrosis transmembrane conductance regulator; Channel conductancecontrolling ATPase; cAMP-dependent chloride channel; cAMPdependent chloride channel; ATP-binding cassette sub-family C member 7; ATPbinding cassette subfamily C member 7; ABCC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [36]
2 Affinity Capture-Western [36]
Isomerases [+] 5 Isomerases +
Interacting Protein Name Prostaglandin E synthase 3 (PTGES3) Interacting Protein Interacting Protein Info
UniProt ID
TEBP_HUMAN 
Synonyms P23; TEBP; cPGES
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [18]
3 Affinity Capture-Western [37]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [16]
6 Affinity Capture-Western [19]
7 Affinity Capture-Western [21]
8 Affinity Capture-Western [6]
9 Affinity Capture-Western [23]
10 Affinity Capture-Western [27]
11 Affinity Capture-Western [34]
12 Affinity Capture-Western [38]
13 Affinity Capture-Western [39]
14 Affinity Capture-Western [40]
15 Reconstituted Complex [41]
16 Reconstituted Complex [27]
17 Reconstituted Complex [42]
18 Reconstituted Complex [43]
19 Yeast two hybrid [44]
20 Yeast two hybrid [45]
Interacting Target Name FK506-binding protein 4 (FKBP4) Literature-reported Target Interacting Protein Info
UniProt ID
FKBP4_HUMAN 
Synonyms PPIase FKBP4; Peptidyl-prolyl cis-trans isomerase FKBP4; P59 protein; p59; Immunophilin FKBP52; HSP-binding immunophilin; HSP binding immunophilin; HBI; FKBP59; FKBP52 protein; FKBP-52; FKBP52; FKBP-4; 59 kDa immunophilin; 52 kDa FKBP; 52 kDa FK506-binding protein; 52 kDa FK506 binding protein
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [4]
4 Co-fractionation [29]
5 Reconstituted Complex [46]
Interacting Target Name FK506-binding protein 5 (FKBP5) Literature-reported Target Interacting Protein Info
UniProt ID
FKBP5_HUMAN 
Synonyms PPIase FKBP5; Peptidyl-prolyl cis-trans isomerase FKBP5; HSP90-binding immunophilin; FKBP54; FKBP-51; FKBP51; FKBP-5; FF1 antigen; Androgen-regulated protein 6; AIG6; 54 kDa progesterone receptor-associated immunophilin; 51 kDa FKBP; 51 kDa FK506-binding protein
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [37]
5 Co-fractionation [29]
Interacting Target Name Rotamase D (PPID) Patented-recorded Target Interacting Protein Info
UniProt ID
PPID_HUMAN 
Synonyms PPIase D; Peptidylprolyl isomerase D; Peptidyl-prolyl cis-trans isomerase D; CYPD; CYP-40; CYP40; Cyclophilin-related protein; Cyclophilin-40; 40 kDa peptidyl-prolyl cis-trans isomerase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [47]
2 Co-purification [48]
3 Reconstituted Complex [47]
Interacting Protein Name Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) Interacting Protein Interacting Protein Info
UniProt ID
FKBP8_HUMAN 
Synonyms FKBP38; FKBPr38
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [49]
3 Affinity Capture-Western [50]
Kinases [+] 30 Kinases +
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [18]
3 Affinity Capture-Western [20]
4 Affinity Capture-Western [52]
5 Affinity Capture-Western [53]
6 Affinity Capture-Western [54]
7 Affinity Capture-Western [55]
Interacting Target Name Erbb2 tyrosine kinase receptor (HER2) Successful Target Interacting Protein Info
UniProt ID
ERBB2_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER2; Tyrosine kinase receptor ErbB2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; P185erbB2; NGL; NEU proto-oncogene; NEU; MLN19; MLN 19; Metastatic lymph node gene 19 protein; HER2/neu; HER2 (erbB2/neu); HER-2; Erb2; Epidermal growth factor receptor 2; C-erbB-2 oncoprotein; C-erbB-2; CD340
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [56]
3 Affinity Capture-Western [18]
4 Affinity Capture-Western [19]
5 Affinity Capture-Western [21]
6 Affinity Capture-Western [57]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Clinical trial Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [58]
2 Affinity Capture-Western [59]
3 Affinity Capture-Western [60]
4 Affinity Capture-Western [61]
5 Co-localization [59]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [62]
2 Affinity Capture-Western [63]
3 Protein-Fragment Complementation Assay [64]
4 Yeast two hybrid [65]
Interacting Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target Interacting Protein Info
UniProt ID
CDK4_HUMAN 
Synonyms PSK-J3; Cell division protein kinase 4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [19]
3 Affinity Capture-Western [21]
4 Affinity Capture-Western [52]
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [66]
3 Affinity Capture-Western [67]
Interacting Target Name Telomerase reverse transcriptase (TERT) Clinical trial Target Interacting Protein Info
UniProt ID
TERT_HUMAN 
Synonyms TRT; TP2; Telomerase-associated protein 2; Telomerase catalytic subunit; TCS1; HEST2; EST2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [58]
2 Affinity Capture-Western [68]
3 Reconstituted Complex [69]
Interacting Target Name TGF-beta receptor type I (TGFBR1) Clinical trial Target Interacting Protein Info
UniProt ID
TGFR1_HUMAN 
Synonyms Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; TbetaR-I; TbetaRI; SKR4; Serine/threonine-protein kinase receptor R4; ALK-5; ALK5; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [70]
2 Affinity Capture-Western [71]
3 Reconstituted Complex [70]
Interacting Target Name TGF-beta receptor type II (TGFBR2) Clinical trial Target Interacting Protein Info
UniProt ID
TGFR2_HUMAN 
Synonyms Transforminggrowth factor-beta receptor type II; Transforming growth factor-beta receptor type II; TGFR-2; TGF-beta type II receptor; TGF-beta receptor type-2; TbetaR-II
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [70]
2 Affinity Capture-Western [71]
3 Reconstituted Complex [70]
Interacting Target Name Leucine-rich repeat kinase 2 (LRRK2) Clinical trial Target Interacting Protein Info
UniProt ID
LRRK2_HUMAN 
Synonyms PARK8; LRRK2 S935 phosphorylation; LRRK2 G2019S mutation; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [72]
2 Affinity Capture-Western [73]
3 Biochemical Activity [74]
Interacting Target Name Protein kinase C zeta (PRKCZ) Patented-recorded Target Interacting Protein Info
UniProt ID
KPCZ_HUMAN 
Synonyms Protein kinase C zeta type; PKC2; NPKC-zeta
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [75]
2 Affinity Capture-Western [51]
3 Yeast two hybrid [76]
Interacting Target Name Activated CDC42 kinase 1 (ACK-1) Patented-recorded Target Interacting Protein Info
UniProt ID
ACK1_HUMAN 
Synonyms Tyrosine kinase non-receptor protein 2; Tyrosine kinase nonreceptor protein 2; ACK-1; ACK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [77]
3 Affinity Capture-Western [78]
Interacting Target Name Tropomyosin-related kinase A (TrkA) Successful Target Interacting Protein Info
UniProt ID
NTRK1_HUMAN 
Synonyms Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; NGF-trk receptor type A; Neurotrophic tyrosine kinase receptor type 1; MTC; High affinity nerve growth factor receptor; gp140trk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [79]
2 Affinity Capture-Western [80]
Interacting Target Name Fyn tyrosine protein kinase (FYN) Successful Target Interacting Protein Info
UniProt ID
FYN_HUMAN 
Synonyms Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Fyn Protooncogene Syn; Fyn p59-Fyn
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [81]
2 Affinity Capture-Western [82]
Interacting Target Name Tyrosine-protein kinase UFO (AXL) Successful Target Interacting Protein Info
UniProt ID
UFO_HUMAN 
Synonyms UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [83]
Interacting Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target Interacting Protein Info
UniProt ID
GSK3B_HUMAN 
Synonyms Serine/threonine-protein kinase GSK3B; GSK-3 beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [84]
2 Biochemical Activity [5]
Interacting Target Name Aurora kinase B (AURKB) Clinical trial Target Interacting Protein Info
UniProt ID
AURKB_HUMAN 
Synonyms STK5; STK12; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora/IPL1-related kinase 2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK-2; ARK2; AIRK2; AIM-1; AIM1; AIK2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [81]
2 Affinity Capture-Western [51]
Interacting Target Name Checkpoint kinase-1 (CHK1) Clinical trial Target Interacting Protein Info
UniProt ID
CHK1_HUMAN 
Synonyms Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Chk1; Cell cycle checkpoint kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [85]
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Reconstituted Complex [86]
Interacting Target Name Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target Interacting Protein Info
UniProt ID
PIM1_HUMAN 
Synonyms PIM; Pim-1 proto-oncogene, serine/threonine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [87]
2 Affinity Capture-Western [87]
Interacting Target Name NF-kappa-B-activating kinase (TBK1) Patented-recorded Target Interacting Protein Info
UniProt ID
TBK1_HUMAN 
Synonyms TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [88]
Interacting Target Name Mixed lineage kinase 3 (MAP3K11) Literature-reported Target Interacting Protein Info
UniProt ID
M3K11_HUMAN 
Synonyms Src-homology 3 domain-containing proline-rich kinase; SPRK; SH3 domain-containing proline-rich kinase; PTK1; Protein-tyrosine kinase PTK1; MLK3; Mixed-lineage protein kinase 3; Mitogen-activated protein kinase kinase kinase 11
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [89]
2 Affinity Capture-Western [89]
Interacting Target Name Tyrosine-protein kinase EIF2AK2 (p68) Patented-recorded Target Interacting Protein Info
UniProt ID
E2AK2_HUMAN 
Synonyms Proteinkinase RNA-activated; Protein kinase RNA-activated; Protein kinase R; PRKR; PKR; p68 kinase; P1/eIF-2A protein kinase; Interferon-inducible RNA-dependent protein kinase; Interferon-induced, double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [90]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [91]
Interacting Target Name Casein kinase I alpha (CSNK1A1) Clinical trial Target Interacting Protein Info
UniProt ID
KC1A_HUMAN 
Synonyms CKI-alpha; CK1; Casein kinase I isoform alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-MS [1]
Interacting Target Name Serine/threonine-protein kinase NIK (MAP3K14) Literature-reported Target Interacting Protein Info
UniProt ID
M3K14_HUMAN 
Synonyms NIK; NF-kappa-beta-inducing kinase; Mitogen-activated protein kinase kinase kinase 14; HsNIK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [92]
Interacting Target Name Myosin light chain kinase 2 (MYLK2) Literature-reported Target Interacting Protein Info
UniProt ID
MYLK2_HUMAN 
Synonyms MYLK2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-MS [1]
Interacting Target Name Fused homolog (STK36) Literature-reported Target Interacting Protein Info
UniProt ID
STK36_HUMAN 
Synonyms Serine/threonine-protein kinase 36; KIAA1278
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [93]
2 Affinity Capture-Western [94]
Interacting Protein Name RNA polymerase II subunit E (POLR2E) Interacting Protein Interacting Protein Info
UniProt ID
RPAB1_HUMAN 
Synonyms RPABC1; RPB5; XAP4; hRPB25; hsRPB5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target Interacting Protein Info
UniProt ID
CDK9_HUMAN 
Synonyms Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2-related kinase; CDC2L4; C-2K
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [81]
Nuclear hormone receptors [+] 5 Nuclear hormone receptors +
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [95]
3 Affinity Capture-Western [96]
4 Affinity Capture-Western [16]
5 Affinity Capture-Western [20]
6 Affinity Capture-Western [21]
7 Affinity Capture-Western [52]
8 Affinity Capture-Western [97]
9 Reconstituted Complex [32]
10 Reconstituted Complex [98]
11 Reconstituted Complex [28]
12 Reconstituted Complex [99]
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [53]
3 Affinity Capture-Western [100]
4 Affinity Capture-Western [101]
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [102]
2 Reconstituted Complex [103]
3 Yeast two hybrid [104]
Interacting Target Name Orphan nuclear receptor NR1I3 (NR1I3) Successful Target Interacting Protein Info
UniProt ID
NR1I3_HUMAN 
Synonyms Orphan nuclear receptor MB67; Orphan nuclear receptor CAR; Nuclear receptor subfamily 1 group I member 3; Nuclear receptor CAR; Constitutive androstane receptor; Constitutive active response; Constitutive activator of retinoid response; CAR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [105]
Interacting Target Name Peroxisome proliferator-activated receptor delta (PPARD) Clinical trial Target Interacting Protein Info
UniProt ID
PPARD_HUMAN 
Synonyms PPAR-delta; PPARdelta; PPAR-beta; PPARB; Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Yeast two hybrid [101]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name SET and MYND domain-containing protein 2 (SMYD2) Preclinical Target Interacting Protein Info
UniProt ID
SMYD2_HUMAN 
Synonyms N-lysine methyltransferase SMYD2; Nlysine methyltransferase SMYD2; Lysine N-methyltransferase 3C; Lysine Nmethyltransferase 3C; KMT3C; HSKM-B; HSKMB; Histone methyltransferase SMYD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [106]
2 Biochemical Activity [107]
Oxidoreductases [+] 4 Oxidoreductases +
Interacting Target Name Nitric-oxide synthase endothelial (NOS3) Clinical trial Target Interacting Protein Info
UniProt ID
NOS3_HUMAN 
Synonyms NOSIII; NOS,type III; NOS type III; Nitric oxide synthase, endothelial; ENOS; Endothelial NOS; Endothelial nitric oxide synthase; EC-NOS; Constitutive NOS; CNOS
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [108]
2 Affinity Capture-Western [109]
3 Affinity Capture-Western [110]
4 Affinity Capture-Western [111]
5 Reconstituted Complex [110]
6 Reconstituted Complex [112]
Interacting Target Name Nitric-oxide synthase inducible (NOS2) Clinical trial Target Interacting Protein Info
UniProt ID
NOS2_HUMAN 
Synonyms Peptidyl-cysteine S-nitrosylase NOS2; NOS2A; NOS, type II; NOS type II; Nitric oxide synthase, inducible; INOS; Inducible NOS; Inducible NO synthase; Inducible nitric oxide synthase; HEP-NOS; Hepatocyte NOS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [113]
2 Affinity Capture-Western [114]
Interacting Target Name Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Clinical trial Target Interacting Protein Info
UniProt ID
G3P_HUMAN 
Synonyms Peptidyl-cysteine S-nitrosylase GAPDH; OK/SW-cl.12; GAPD; D-glyceraldehyde-3-phosphate dehydrogenase; CDABP0047
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [31]
2 Co-fractionation [30]
Interacting Target Name HIF-prolyl hydroxylase 2 (HPH-2) Patented-recorded Target Interacting Protein Info
UniProt ID
EGLN1_HUMAN 
Synonyms SM-20; SM20; Prolyl hydroxylase domain-containing protein 2; Prolyl hydroxylase domaincontaining protein 2; PNAS-137; PNAS-118; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; Hypoxiainducible factor prolyl hydroxylase 2; HPH2; HIFprolyl hydroxylase 2; HIF-PH2; HIFPH2; Egl nine homolog 1; C1orf12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [115]
2 Reconstituted Complex [116]
Peptidases [+] 2 Peptidases +
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 19 (USP19) Interacting Protein Interacting Protein Info
UniProt ID
UBP19_HUMAN 
Synonyms ZMYND9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [117]
3 Affinity Capture-Western [118]
Interacting Target Name Ubiquitin thioesterase L1 (UCHL1) Preclinical Target Interacting Protein Info
UniProt ID
UCHL1_HUMAN 
Synonyms UCH-L1; Ubiquitin thiolesterase L1; Ubiquitin carboxy-terminal hydrolase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [119]
2 Reconstituted Complex [120]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [51]
2 Affinity Capture-Western [121]
3 Biochemical Activity [11]
4 Reconstituted Complex [122]
Ribosomal proteins [+] 4 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein uL18 (RPL5) Interacting Protein Interacting Protein Info
UniProt ID
RL5_HUMAN 
Synonyms DBA6; L5; PPP1R135
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [31]
2 Co-fractionation [123]
Interacting Protein Name Large ribosomal subunit protein uL30 (RPL7) Interacting Protein Interacting Protein Info
UniProt ID
RL7_HUMAN 
Synonyms L7; humL7.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [31]
2 Co-fractionation [123]
Interacting Protein Name Small ribosomal subunit protein eS1 (RPS3A) Interacting Protein Interacting Protein Info
UniProt ID
RS3A_HUMAN 
Synonyms FTE1; MFTL; S3A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [31]
2 Affinity Capture-Western [124]
Interacting Protein Name Small ribosomal subunit protein eS6 (RPS6) Interacting Protein Interacting Protein Info
UniProt ID
RS6_HUMAN 
Synonyms S6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [31]
2 Affinity Capture-Western [35]
Transcription regulators [+] 6 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [125]
2 Affinity Capture-Western [126]
3 Affinity Capture-Western [127]
4 Affinity Capture-Western [128]
5 Affinity Capture-Western [129]
6 Affinity Capture-Western [130]
7 Affinity Capture-Western [131]
8 Reconstituted Complex [132]
9 Reconstituted Complex [133]
10 Yeast two hybrid [130]
Interacting Target Name Heat shock protein 70 (HSP70) Clinical trial Target Interacting Protein Info
UniProt ID
HSF1_HUMAN 
Synonyms Molecular chaperone Hsp70; HSTF1; HSTF 1; HSP70; HSF 1; Heat shock transcription factor 1; Heat shock factor protein 1; Heat shock 70 kDa protein; Chaperone protein dnaK
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [134]
2 Affinity Capture-Western [130]
3 Affinity Capture-Western [135]
4 Affinity Capture-Western [136]
5 Affinity Capture-Western [137]
6 Yeast two hybrid [130]
Interacting Target Name Aryl hydrocarbon receptor (AHR) Successful Target Interacting Protein Info
UniProt ID
AHR_HUMAN 
Synonyms Class E basic helix-loop-helix protein 76; Class E basic helixloophelix protein 76; bHLHe76; AhR; Ah receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [138]
2 Reconstituted Complex [139]
3 Reconstituted Complex [138]
Interacting Target Name Interferon regulatory factor 3 (IRF3) Literature-reported Target Interacting Protein Info
UniProt ID
IRF3_HUMAN 
Synonyms IRF-3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [88]
2 Reconstituted Complex [140]
3 Yeast two hybrid [88]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [141]
2 Reconstituted Complex [141]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [142]
2 Yeast two hybrid [76]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [143]
2 Affinity Capture-Western [144]
3 Co-purification [11]
4 Protein-peptide [145]
5 Reconstituted Complex [11]
Other proteins [+] 14 Other proteins +
Interacting Protein Name Stress-induced-phosphoprotein 1 (STIP1) Interacting Protein Interacting Protein Info
UniProt ID
STIP1_HUMAN 
Synonyms HEL.S.94n; HOP; IEF.SSP.3521; P60; STI1; STI1L
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [17]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [19]
6 Affinity Capture-Western [20]
7 Affinity Capture-Western [21]
8 Affinity Capture-Western [6]
9 Affinity Capture-Western [23]
10 Affinity Capture-Western [26]
11 Affinity Capture-Western [39]
12 Reconstituted Complex [146]
13 Reconstituted Complex [147]
14 Reconstituted Complex [148]
Interacting Protein Name Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) Interacting Protein Interacting Protein Info
UniProt ID
AHSA1_HUMAN 
Synonyms AHA1; C14orf3; p38
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [149]
3 Affinity Capture-Western [18]
4 Affinity Capture-Western [19]
5 Affinity Capture-Western [20]
6 Affinity Capture-Western [21]
7 Affinity Capture-Western [6]
8 Affinity Capture-Western [22]
9 Co-fractionation [30]
10 Reconstituted Complex [149]
11 Reconstituted Complex [25]
12 Reconstituted Complex [150]
13 Yeast two hybrid [149]
Interacting Target Name Suppressor of G2 allele of SKP1 homolog (Sgt1) Literature-reported Target Interacting Protein Info
UniProt ID
SGT1_HUMAN 
Synonyms Protein SGT1 homolog; Protein 40-6-3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [151]
3 Affinity Capture-Western [152]
4 Co-localization [152]
5 Reconstituted Complex [10]
Interacting Protein Name Calcyclin-binding protein (CACYBP) Interacting Protein Interacting Protein Info
UniProt ID
CYBP_HUMAN 
Synonyms GIG5; S100A6BP; SIP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [152]
3 Co-localization [152]
4 Reconstituted Complex [152]
Interacting Protein Name DnaJ homolog subfamily C member 7 (DNAJC7) Interacting Protein Interacting Protein Info
UniProt ID
DNJC7_HUMAN 
Synonyms DJ11; DJC7; TPR2; TTC2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [4]
3 Yeast two hybrid [33]
Interacting Protein Name RNA polymerase II-associated protein 3 (RPAP3) Interacting Protein Interacting Protein Info
UniProt ID
RPAP3_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [153]
Interacting Target Name HCLS1-associated protein X-1 (HAX1) Literature-reported Target Interacting Protein Info
UniProt ID
HAX1_HUMAN 
Synonyms HSP1BP-1; HS1BP1; HS1-binding protein 1; HS1-associating protein X-1; HAX-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [59]
2 Co-localization [59]
Interacting Protein Name AH receptor-interacting protein (AIP) Interacting Protein Interacting Protein Info
UniProt ID
AIP_HUMAN 
Synonyms ARA9; FKBP16; FKBP37; SMTPHN; XAP.2; XAP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [139]
Interacting Protein Name DnaJ homolog subfamily A member 2 (DNAJA2) Interacting Protein Interacting Protein Info
UniProt ID
DNJA2_HUMAN 
Synonyms CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4; PRO3015; RDJ2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Co-fractionation [30]
Interacting Protein Name Tubulin alpha-1A chain (TUBA1A) Interacting Protein Interacting Protein Info
UniProt ID
TBA1A_HUMAN 
Synonyms B.ALPHA.1; LIS3; TUBA3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [134]
Interacting Protein Name Mitochondrial import receptor subunit TOM34 (TOMM34) Interacting Protein Interacting Protein Info
UniProt ID
TOM34_HUMAN 
Synonyms HTOM34P; TOM34; URCC3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Tropomyosin alpha-3 chain (TPM3) Interacting Protein Interacting Protein Info
UniProt ID
TPM3_HUMAN 
Synonyms CAPM1; CFTD; HEL.189; HEL.S.82p; NEM1; OK/SW.cl.5; TM.5; TM3; TM30; TM30nm; TM5; TPMsk3; TRK; hscp30
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [31]
2 Co-fractionation [29]
Interacting Protein Name Tetratricopeptide repeat protein 4 (TTC4) Interacting Protein Interacting Protein Info
UniProt ID
TTC4_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Protein unc-45 homolog A (UNC45A) Interacting Protein Interacting Protein Info
UniProt ID
UN45A_HUMAN 
Synonyms GC.UNC45; GCUNC.45; GCUNC45; IRO039700; SMAP.1; SMAP1; UNC.45A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [154]
References  Top
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