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| Protein General Information (TTD Target) |
Top |
| Full Name |
Telomerase reverse transcriptase (TERT)
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Clinical trial
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Target Info
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| UniProt ID |
TERT_HUMAN
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| Gene Name |
TERT
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| Gene ID |
7015
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| Interacting TTD Target Information |
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| Interacting Successful Target(s) |
Heat shock protein 90 alpha (HSP90A) |
Target Info
|
PPI Info
|
[1] |
| RAC-alpha serine/threonine-protein kinase (AKT1) |
Target Info
|
PPI Info
|
[2] |
| Interacting Clinical trial Target(s) |
Ubiquitin-protein ligase E3 Mdm2 (MDM2) |
Target Info
|
PPI Info
|
[3] |
| Interacting Literature-reported Target(s) |
X-ray repair cross-complementing 5 (Ku80) |
Target Info
|
PPI Info
|
[4] |
| References |
Top |
| REF 1 |
Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett. 2003 Feb 11;536(1-3):180-6.
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| REF 2 |
Pectenotoxin-2 represses telomerase activity in human leukemia cells through suppression of hTERT gene expression and Akt-dependent hTERT phosphorylation. FEBS Lett. 2008 Oct 15;582(23-24):3263-9.
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| REF 3 |
Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT. Oncogene. 2010 Jul 15;29(28):4101-12.
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| REF 4 |
Human Ku70/80 associates physically with telomerase through interaction with hTERT. J Biol Chem. 2002 Dec 6;277(49):47242-7.
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