Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Serine/threonine-protein kinase NIK (MAP3K14) | Literature-reported | Target Info | ||
| UniProt ID | M3K14_HUMAN | ||||
| Gene Name | MAP3K14 | ||||
| Gene ID | 9020 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Heat shock protein 90 alpha (HSP90A) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Inhibitor of nuclear factor kappa-B kinase beta (IKKB) | Target Info | PPI Info | [2] | |
| Interacting Literature-reported Target(s) | Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) | Target Info | PPI Info | [3] | |
| Serine/threonine-protein kinase NIK (MAP3K14) | Target Info | PPI Info | [4] | ||
| TNF receptor-associated factor 6 (TRAF6) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001. | ||||
| REF 2 | Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40. J Biol Chem. 2001 May 4;276(18):14602-6. | ||||
| REF 3 | Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor. J Biol Chem. 2010 May 28;285(22):17148-55. | ||||
| REF 4 | Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain. J Biol Chem. 2000 Jul 14;275(28):21081-5. | ||||
| REF 5 | ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction. J Biol Chem. 2000 Oct 20;275(42):32747-52. | ||||
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