Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Interferon regulatory factor 3 (IRF3) | Literature-reported | Target Info | ||
UniProt ID | IRF3_HUMAN | ||||
Gene Name | IRF3 | ||||
Gene ID | 3661 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Heat shock protein 90 alpha (HSP90A) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | CREB-binding protein (CREBBP) | Target Info | PPI Info | [2] | |
Histone acetyltransferase p300 (EP300) | Target Info | PPI Info | [4] | ||
Interacting Patented-recorded Target(s) | NF-kappa-B-activating kinase (TBK1) | Target Info | PPI Info | [3] | |
Interacting Literature-reported Target(s) | Interferon regulatory factor 3 (IRF3) | Target Info | PPI Info | [5] |
References | Top | ||||
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REF 1 | Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell. 2006 Mar;17(3):1461-71. | ||||
REF 2 | Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol. 1998 May;18(5):2986-96. | ||||
REF 3 | The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep. 2008 Sep;9(9):930-6. | ||||
REF 4 | HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene. 2001 Feb 15;20(7):800-11. | ||||
REF 5 | Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science. 2015 Mar 13;347(6227):aaa2630. |
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