Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T38017 Target Info
Target Name Interferon regulatory factor 3 (IRF3)
Synonyms IRF-3
Target Type Literature-reported Target
Gene Name IRF3
UniProt ID
IRF3_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-localization [5]
6 Protein-peptide [4]
7 Reconstituted Complex [5]
Interacting Protein Name E3 ubiquitin-protein ligase TRIM21 (TRIM21) Interacting Protein Interacting Protein Info
UniProt ID
RO52_HUMAN 
Synonyms RNF81; RO52; Ro/SSA; SSA; SSA1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [7]
4 Reconstituted Complex [6]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [9]
4 Yeast two hybrid [8]
Kinases [+] 1 Kinases +
Interacting Target Name NF-kappa-B-activating kinase (TBK1) Patented-recorded Target Interacting Protein Info
UniProt ID
TBK1_HUMAN 
Synonyms TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [11]
5 Affinity Capture-Western [12]
6 Reconstituted Complex [13]
7 Reconstituted Complex [12]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [14]
4 Affinity Capture-Western [15]
5 Affinity Capture-Western [16]
6 Affinity Capture-Western [17]
7 Affinity Capture-Western [3]
8 Affinity Capture-Western [18]
9 Affinity Capture-Western [19]
10 Co-crystal Structure [20]
11 Co-localization [5]
Interacting Protein Name Interferon regulatory factor 7 (IRF7) Interacting Protein Interacting Protein Info
UniProt ID
IRF7_HUMAN 
Synonyms IRF.7H; IRF7A; IRF7B; IRF7C; IRF7H
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [21]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Mitochondrial antiviral-signaling protein (MAVS) Interacting Protein Interacting Protein Info
UniProt ID
MAVS_HUMAN 
Synonyms CARDIF; IPS.1; IPS1; VISA
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [22]
3 Affinity Capture-Western [23]
4 Affinity Capture-Western [12]
5 Reconstituted Complex [12]
Interacting Protein Name Inhibitor of nuclear factor kappa-B kinase (IKK) Interacting Protein Interacting Protein Info
UniProt ID
Family 
Synonyms IKK; IB kinase; IkappaB kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Biochemical Activity [11]
References  Top
REF 1 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 2 Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell. 1998 Mar;1(4):507-18.
REF 3 Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol Cell Biol. 1998 Mar;18(3):1359-68.
REF 4 Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change. Genes Cells. 2010 Aug;15(8):901-10.
REF 5 Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. J Biol Chem. 2002 Jun 21;277(25):22304-13.
REF 6 TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response. J Immunol. 2009 Mar 15;182(6):3782-92.
REF 7 The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. J Immunol. 2008 Aug 1;181(3):1780-6.
REF 8 Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell. 2006 Mar;17(3):1461-71.
REF 9 Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. Cell Res. 2010 Sep;20(9):994-1011.
REF 10 NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. Nat Immunol. 2012 Mar 4;13(4):387-95.
REF 11 Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 Apr;19(4):362-374.
REF 12 Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science. 2015 Mar 13;347(6227):aaa2630.
REF 13 Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci. 2015 May;18(5):631-6.
REF 14 Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. J Biol Chem. 2007 Nov 2;282(44):32208-21.
REF 15 Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction. Virology. 2007 Apr 10;360(2):305-21.
REF 16 Promyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment To Activate Interferon Beta and Interferon-Responsive Gene Expression. Mol Cell Biol. 2015 May;35(10):1660-72.
REF 17 Activation of interferon regulatory factor 3 in response to DNA-damaging agents. J Biol Chem. 1999 Oct 22;274(43):30686-9.
REF 18 Oxidized low density lipoprotein blocks lipopolysaccharide-induced interferon beta synthesis in human macrophages by interfering with IRF3 activation. J Biol Chem. 2004 Jul 2;279(27):28781-8.
REF 19 Thogoto virus ML protein suppresses IRF3 function. Virology. 2005 Jan 5;331(1):63-72.
REF 20 Crystal structure of IRF-3 in complex with CBP. Structure. 2005 Sep;13(9):1269-77.
REF 21 Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3. Virology. 2001 Feb 15;280(2):273-82.
REF 22 Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner. J Biol Chem. 2012 Oct 5;287(41):34626-34.
REF 23 VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell. 2005 Sep 16;19(6):727-40.
REF 24 The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep. 2008 Sep;9(9):930-6.

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