Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Checkpoint kinase-1 (CHK1) | Clinical trial | Target Info | ||
UniProt ID | CHK1_HUMAN | ||||
Gene Name | CHEK1 | ||||
Gene ID | 1111 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Heat shock protein 90 alpha (HSP90A) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | ATM serine/threonine kinase (ATM) | Target Info | PPI Info | [2] | |
Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [3] | ||
Serine/threonine-protein kinase ATR (FRP1) | Target Info | PPI Info | [4] | ||
Interacting Preclinical Target(s) | Herpesvirus ubiquitin-specific protease (HAUSP) | Target Info | PPI Info | [5] | |
Interacting Literature-reported Target(s) | M-phase inducer phosphatase 1 (MPIP1) | Target Info | PPI Info | [6] |
References | Top | ||||
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REF 1 | Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001. | ||||
REF 2 | Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell. 2003 Mar;3(3):247-58. | ||||
REF 3 | Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia. 2002 Mar-Apr;4(2):171-80. | ||||
REF 4 | Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 2005 Mar 23;24(6):1157-69. | ||||
REF 5 | USP7 regulates the stability and function of HLTF through deubiquitination. J Cell Biochem. 2011 Dec;112(12):3856-62. | ||||
REF 6 | Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44. |
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