| References |
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| REF 1 |
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci. 2006 Dec 15;119(Pt 24):5137-46.
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| REF 2 |
WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes. J Cell Sci. 2011 Dec 1;124(Pt 23):3967-79.
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| REF 3 |
Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem. 1999 Dec 31;274(53):37538-43.
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| REF 4 |
Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res. 2000 Sep 15;60(18):5037-9.
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| REF 5 |
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J Biol Chem. 2001 May 18;276(20):17276-80.
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| REF 6 |
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 2000 Dec 1;14(23):2989-3002.
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| REF 7 |
hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J Biol Chem. 2011 Mar 25;286(12):10411-8.
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| REF 8 |
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15387-92.
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| REF 9 |
Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Mol Cell Biol. 2012 Feb;32(4):783-96.
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| REF 10 |
Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation. Mol Cell Biol. 2009 Dec;29(23):6206-19.
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| REF 11 |
Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 2005 Mar 23;24(6):1157-69.
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| REF 12 |
Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage. Mol Cancer Ther. 2011 Jul;10(7):1194-206.
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| REF 13 |
Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. Oncogene. 2009 May 7;28(18):1971-81.
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| REF 14 |
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13301-6.
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| REF 15 |
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol. 2001 Jul;21(13):4129-39.
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| REF 16 |
A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death Differ. 2011 Jan;18(1):5-15.
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| REF 17 |
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J. 2006 Dec 13;25(24):5775-82.
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| REF 18 |
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001 Jul 15;15(14):1833-44.
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| REF 19 |
The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53. Oncogene. 1999 Jul 8;18(27):3989-95.
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| REF 20 |
DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J Biol Chem. 2006 Jan 20;281(3):1692-7.
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| REF 21 |
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem. 2004 Jul 23;279(30):31251-8.
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| REF 22 |
ATR and ATRIP: partners in checkpoint signaling. Science. 2001 Nov 23;294(5547):1713-6.
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| REF 23 |
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature. 2005 Mar 31;434(7033):605-11.
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| REF 24 |
HCLK2 is required for activity of the DNA damage response kinase ATR. J Biol Chem. 2009 Feb 13;284(7):4140-7.
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| REF 25 |
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev. 2008 Mar 1;22(5):587-600.
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| REF 26 |
ATR-dependent phosphorylation of ATRIP in response to genotoxic stress. Biochem Biophys Res Commun. 2004 Oct 29;323(4):1197-202.
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| REF 27 |
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem. 2008 Mar 7;283(10):6572-83.
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| REF 28 |
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nat Cell Biol. 2007 Apr;9(4):391-401.
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| REF 29 |
Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19304-9.
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| REF 30 |
A novel protein activity mediates DNA binding of an ATR-ATRIP complex. J Biol Chem. 2004 Apr 2;279(14):13346-53.
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| REF 31 |
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature. 2001 Jun 21;411(6840):969-74.
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| REF 32 |
Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. EMBO J. 2010 May 19;29(10):1726-37.
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| REF 33 |
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol. 2006 Sep;26(18):7005-15.
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| REF 34 |
ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway. Cancer Res. 2012 Mar 1;72(5):1149-56.
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| REF 35 |
The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J. 2004 Mar 10;23(5):1178-87.
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| REF 36 |
NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites. DNA Repair (Amst). 2013 Apr 1;12(4):273-83.
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