| References |
Top |
| REF 1 |
Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
|
| REF 2 |
USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol. 2016 Apr;23(4):270-7.
|
| REF 3 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
|
| REF 4 |
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res. 2011 Oct;39(19):8355-65.
|
| REF 5 |
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4828-33.
|
| REF 6 |
Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7. PLoS Pathog. 2015 Jun 5;11(6):e1004950.
|
| REF 7 |
Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1. J Cell Biochem. 2011 Feb;112(2):439-44.
|
| REF 8 |
An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Rep. 2015 Sep 1;12(9):1400-6.
|
| REF 9 |
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J. 2010 Aug 4;29(15):2553-65.
|
| REF 10 |
USP7 cooperates with SCML2 to regulate the activity of PRC1. Mol Cell Biol. 2015 Apr;35(7):1157-68.
|
| REF 11 |
Regulation of the Polycomb protein RING1B ubiquitination by USP7. Biochem Biophys Res Commun. 2010 Sep 24;400(3):389-95.
|
| REF 12 |
Dual-utility NLS drives RNF169-dependent DNA damage responses. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2872-E2881.
|
| REF 13 |
The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of -catenin. Mol Cell Biol. 2014 Dec 1;34(23):4355-66.
|
| REF 14 |
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell. 2006 May 19;125(4):801-14.
|
| REF 15 |
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010 Aug;17(8):939-47.
|
| REF 16 |
A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J Biol Chem. 2001 Jun 29;276(26):24242-52.
|
| REF 17 |
Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response. FEBS Lett. 2016 Dec;590(23):4213-4222.
|
| REF 18 |
Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. J Biol Chem. 2012 Dec 14;287(51):43007-18.
|
| REF 19 |
Quantitative Lys--Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. J Biol Chem. 2014 Oct 17;289(42):28942-55.
|
| REF 20 |
SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 1;27(3):274-87.
|
| REF 21 |
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell. 2012 Mar 30;45(6):801-13.
|
| REF 22 |
Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec;15(12):1486-1494.
|
| REF 23 |
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat Cell Biol. 2015 Sep;17(9):1169-81.
|
| REF 24 |
ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53. Nat Commun. 2014 Oct 6;5:5059.
|
| REF 25 |
USP11 Is a Negative Regulator to H2AX Ubiquitylation by RNF8/RNF168. J Biol Chem. 2016 Jan 8;291(2):959-67.
|
| REF 26 |
USP7 regulates the stability and function of HLTF through deubiquitination. J Cell Biochem. 2011 Dec;112(12):3856-62.
|
| REF 27 |
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep;16(9):864-75.
|
| REF 28 |
USP7 controls Chk1 protein stability by direct deubiquitination. Cell Cycle. 2014;13(24):3921-6.
|
| REF 29 |
EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog. 2009 Oct;5(10):e1000624.
|
| REF 30 |
GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. Mol Cell. 2005 Mar 4;17(5):695-707.
|
| REF 31 |
Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization. Mol Cell. 2014 Feb 6;53(3):458-70.
|
| REF 32 |
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal. 2010 Nov 2;3(146):ra80.
|
| REF 33 |
Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun. 2015 May 11;6:7023.
|
| REF 34 |
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002 Apr 11;416(6881):648-53.
|
| REF 35 |
Critical role for Daxx in regulating Mdm2. Nat Cell Biol. 2006 Aug;8(8):855-62.
|
| REF 36 |
Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. Cell Death Differ. 2007 Jul;14(7):1350-60.
|
| REF 37 |
The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP. Oncogene. 2007 Nov 8;26(51):7262-6.
|
| REF 38 |
HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response. Sci Rep. 2015 Aug 4;5:12793.
|
| REF 39 |
FAM188B enhances cell survival via interaction with USP7. Cell Death Dis. 2018 May 24;9(6):633.
|
| REF 40 |
STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation. Oncotarget. 2015 Oct 27;6(33):34718-31.
|
| REF 41 |
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol. 2006 Feb;4(2):e27.
|
| REF 42 |
Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nat Struct Mol Biol. 2006 Mar;13(3):285-91.
|
| REF 43 |
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. J Biol Chem. 2003 Nov 28;278(48):47753-61.
|
| REF 44 |
USP51 promotes deubiquitination and stabilization of ZEB1. Am J Cancer Res. 2017 Oct 1;7(10):2020-2031.
|
| REF 45 |
Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. J Cell Biochem. 2008 Oct 1;105(2):596-611.
|
| REF 46 |
Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
|
| REF 47 |
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol Cell Biol. 2006 Sep;26(18):6819-31.
|
| REF 48 |
Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal. 2017 Feb 14;10(466). pii: eaai8026.
|
| REF 49 |
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell. 2007 Oct;12(4):342-54.
|
| REF 50 |
USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. Cell Rep. 2016 Mar 22;14(11):2528-37.
|
| REF 51 |
WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway. Cell Death Dis. 2017 Apr 13;8(4):e2743.
|
| REF 52 |
Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes. Biochemistry. 2016 Aug 23;55(33):4708-19.
|
| REF 53 |
The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chem Biol. 2011 Dec 23;18(12):1550-61.
|
| REF 54 |
Subunit-Specific Labeling of Ubiquitin Chains by Using Sortase: Insights into the Selectivity of Deubiquitinases. Chembiochem. 2016 Aug 17;17(16):1525-31.
|
| REF 55 |
USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538.
|
| REF 56 |
Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure. 2018 Jan 2;26(1):72-84.e7.
|
| REF 57 |
A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5.
|
| REF 58 |
Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation. Structure. 2016 Aug 2;24(8):1335-1345.
|
| REF 59 |
USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms. Cell Chem Biol. 2017 Dec 21;24(12):1501-1512.e5.
|
| REF 60 |
A role for USP7 in DNA replication. Mol Cell Biol. 2014 Jan;34(1):132-45.
|
| REF 61 |
Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies. J Virol. 2010 Nov;84(21):11113-23.
|
| REF 62 |
The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies. PLoS One. 2011 Jan 31;6(1):e16598.
|
