Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Phosphatase and tensin homolog (PTEN) | Literature-reported | Target Info | ||
| UniProt ID | PTEN_HUMAN | ||||
| Gene Name | PTEN | ||||
| Gene ID | 5728 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Casein kinase II alpha (CSNK2A1) | Target Info | PPI Info | [2] | |
| Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [3] | ||
| Focal adhesion kinase 1 (FAK) | Target Info | PPI Info | [4] | ||
| Heat shock protein 90 beta (HSP90B) | Target Info | PPI Info | [5] | ||
| Interacting Preclinical Target(s) | Herpesvirus ubiquitin-specific protease (HAUSP) | Target Info | PPI Info | [6] | |
| Interacting Literature-reported Target(s) | Lipopolysaccharide-associated protein 1 (HSPA8) | Target Info | PPI Info | [5] | |
| E3 ubiquitin-protein ligase NEDD4 (NEDD4) | Target Info | PPI Info | [7] | ||
| NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) | Target Info | PPI Info | [8] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860. | ||||
| REF 2 | Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. Proteomics. 2005 Apr;5(5):1250-62. | ||||
| REF 3 | p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN. Cell Death Differ. 2014 Jan;21(1):146-60. | ||||
| REF 4 | PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem. 1999 Jul 16;274(29):20693-703. | ||||
| REF 5 | WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol. 2011 Jun;13(6):728-33. | ||||
| REF 6 | Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec;15(12):1486-1494. | ||||
| REF 7 | Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell. 2009 Apr 7;15(4):304-14. | ||||
| REF 8 | SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. 2017 Mar 14;8(11):17651-17664. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.