Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T51565 | Target Info | |||
Target Name | Casein kinase II alpha (CSNK2A1) | ||||
Synonyms | Protein kinase CK2; Casein kinase II subunit alpha; CK2A1; CK II alpha; CK II | ||||
Target Type | Clinical trial Target | ||||
Gene Name | CSNK2A1 | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acid anhydride hydrolases | [+] 1 Acid anhydride hydrolases | + | |||
Interacting Protein Name | ATP-dependent RNA helicase DDX54 (DDX54) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DP97 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Biochemical Activity | [2] | |||
Acyltransferases | [+] 1 Acyltransferases | + | |||
Interacting Protein Name | E3 ubiquitin-protein ligase RING2 (RNF2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BAP.1; BAP1; DING; HIPI3; RING1B; RING2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Biochemical Activity | [3] | |||
Auxiliary transporters | [+] 1 Auxiliary transporters | + | |||
Interacting Protein Name | Alpha-S1-casein (CSN1S1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CASA; CSN1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [4] | |||
2 | Reconstituted Complex | [5] | |||
Carbon-nitrogen hydrolases | [+] 2 Carbon-nitrogen hydrolases | + | |||
Interacting Target Name | Histone deacetylase 2 (HDAC2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HD2 | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [6] | |||
2 | Biochemical Activity | [7] | |||
3 | Biochemical Activity | [2] | |||
4 | Biochemical Activity | [8] | |||
5 | Co-fractionation | [9] | |||
6 | Co-fractionation | [10] | |||
Interacting Target Name | Histone deacetylase 1 (HDAC1) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RPD3L1; HD1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [6] | |||
2 | Biochemical Activity | [11] | |||
3 | Biochemical Activity | [2] | |||
4 | Biochemical Activity | [12] | |||
Ester hydrolases | [+] 1 Ester hydrolases | + | |||
Interacting Target Name | Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; MMAC1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [13] | |||
2 | Reconstituted Complex | [14] | |||
Eukaryotic initiation factors | [+] 2 Eukaryotic initiation factors | + | |||
Interacting Protein Name | Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | EIF2; EIF2B; EIF2beta; PPP1R67; eIF.2.beta | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [15] | |||
2 | Biochemical Activity | [15] | |||
3 | Biochemical Activity | [2] | |||
4 | Far Western | [15] | |||
Interacting Protein Name | Eukaryotic translation initiation factor 3 subunit J (EIF3J) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | EIF3S1; eIF3.alpha; eIF3.p35 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [16] | |||
2 | Biochemical Activity | [2] | |||
Heat shock proteins | [+] 1 Heat shock proteins | + | |||
Interacting Target Name | Heat shock protein 90 alpha (HSP90A) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [17] | |||
2 | Biochemical Activity | [2] | |||
Histones | [+] 1 Histones | + | |||
Interacting Target Name | Gamma-Histone H2AX (H2AFX) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2AX; H2a/x | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [18] | |||
2 | Co-localization | [19] | |||
Isomerases | [+] 1 Isomerases | + | |||
Interacting Target Name | DNA topoisomerase II alpha (TOP2A) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TOP2; DNA topoisomerase II, alpha isozyme; DNA topoisomerase 2-alpha; DNA topoisomerase 2alpha | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [2] | |||
2 | Co-fractionation | [9] | |||
Kinases | [+] 4 Kinases | + | |||
Interacting Protein Name | Casein kinase II subunit beta (CSNK2B) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CK2B; CK2N; CSK2B; G5A | ||||
Evidence Score (E-score) | 18 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [16] | |||
2 | Affinity Capture-MS | [1] | |||
3 | Affinity Capture-Western | [20] | |||
4 | Biochemical Activity | [21] | |||
5 | Biochemical Activity | [22] | |||
6 | Biochemical Activity | [23] | |||
7 | Biochemical Activity | [24] | |||
8 | Biochemical Activity | [25] | |||
9 | Co-fractionation | [9] | |||
10 | Co-fractionation | [10] | |||
11 | Far Western | [15] | |||
12 | Reconstituted Complex | [20] | |||
13 | Reconstituted Complex | [3] | |||
14 | Reconstituted Complex | [5] | |||
15 | Yeast two hybrid | [26] | |||
16 | Yeast two hybrid | [27] | |||
17 | Yeast two hybrid | [28] | |||
18 | Yeast two hybrid | [29] | |||
Interacting Target Name | Casein kinase II alpha prime (CSNK2A2) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CK2A2; CK II alpha'; Casein kinase II subunit alpha' | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [16] | |||
3 | Affinity Capture-Western | [22] | |||
4 | Reconstituted Complex | [3] | |||
Interacting Protein Name | Cyclin-dependent kinase 11A (CDK11A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CDC2L2; CDC2L3; CDK11.p110; CDK11.p46; CDK11.p58; PITSLRE; p58GTA | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [16] | |||
2 | Biochemical Activity | [2] | |||
Interacting Protein Name | DNA-directed RNA polymerase II subunit RPB1 (POLR2A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [18] | |||
2 | Biochemical Activity | [30] | |||
Lyases | [+] 1 Lyases | + | |||
Interacting Protein Name | Small ribosomal subunit protein uS3 (RPS3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | S3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [2] | |||
2 | Biochemical Activity | [31] | |||
Peptidases | [+] 1 Peptidases | + | |||
Interacting Protein Name | FACT complex subunit SPT16 (SUPT16H) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CDC68; FACTP140; SPT16/CDC68 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [16] | |||
2 | Co-fractionation | [9] | |||
3 | Co-fractionation | [10] | |||
Pore-forming toxins | [+] 1 Pore-forming toxins | + | |||
Interacting Target Name | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [32] | |||
2 | Biochemical Activity | [21] | |||
3 | Biochemical Activity | [33] | |||
Ribosomal proteins | [+] 1 Ribosomal proteins | + | |||
Interacting Protein Name | Large ribosomal subunit protein uL18 (RPL5) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DBA6; L5; PPP1R135 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [34] | |||
2 | Biochemical Activity | [2] | |||
Transcription regulators | [+] 3 Transcription regulators | + | |||
Interacting Target Name | CREB-binding protein (CREBBP) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CREBbinding protein; CBP | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [35] | |||
2 | Far Western | [36] | |||
3 | Reconstituted Complex | [36] | |||
Interacting Target Name | High mobility group protein HMG-I/Y (HMGA1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HMGIY; HMG-I(Y); High mobility group protein R; High mobility group protein HMG-I/HMG-Y; High mobility group protein A1; High mobility group AT-hook protein 1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [2] | |||
2 | Biochemical Activity | [37] | |||
Interacting Protein Name | Autism susceptibility gene 2 protein (AUTS2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | FBRSL2; MRD26 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Reconstituted Complex | [3] | |||
Other proteins | [+] 18 Other proteins | + | |||
Interacting Target Name | Facilitates chromatin transcription complex (FACT) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | T160; Structure-specific recognition protein 1; Recombination signal sequence recognition protein 1; hSSRP1; FACTp80; FACT80; FACT complex subunit SSRP1; FACT 80 kDa subunit; Facilitates chromatin transcription complex subunit SSRP1; Facilitates chromatin transcription complex 80 kDa subunit; Chromatin-specific transcription elongation factor 80 kDa subunit | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [16] | |||
2 | Biochemical Activity | [2] | |||
3 | Co-fractionation | [9] | |||
4 | Co-fractionation | [10] | |||
Interacting Target Name | von Hippel-Lindau disease tumor suppressor (VHL) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | pVHL; Protein G7 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [38] | |||
2 | Affinity Capture-Western | [39] | |||
3 | Biochemical Activity | [38] | |||
Interacting Protein Name | Calmodulin-1 (CALM1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CALML2; CAMI; CPVT4; DD132; PHKD; caM | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Biochemical Activity | [40] | |||
2 | Biochemical Activity | [15] | |||
3 | Reconstituted Complex | [5] | |||
Interacting Protein Name | HIRA-interacting protein 3 (HIRIP3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [16] | |||
2 | Biochemical Activity | [41] | |||
3 | Biochemical Activity | [2] | |||
Interacting Protein Name | Nucleosome assembly protein 1-like 4 (NAP1L4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | NAP1L4b; NAP2; NAP2L; hNAP2 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Biochemical Activity | [42] | |||
2 | Co-fractionation | [10] | |||
3 | Reconstituted Complex | [42] | |||
Interacting Protein Name | Promyelocytic leukemia protein (PML) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MYL; PP8675; RNF71; TRIM19 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [43] | |||
2 | Biochemical Activity | [44] | |||
3 | Biochemical Activity | [45] | |||
Interacting Protein Name | Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HNRPA2B1; hnRNP A2/B1; Heterogeneous nuclear ribonucleoproteins A2/B1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Biochemical Activity | [46] | |||
2 | Biochemical Activity | [2] | |||
3 | Reconstituted Complex | [46] | |||
Interacting Protein Name | Paired amphipathic helix protein Sin3a (SIN3A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [6] | |||
2 | Co-fractionation | [9] | |||
3 | Co-fractionation | [10] | |||
Interacting Target Name | Nucleolin (NCL) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein C23; Nucleolin | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [2] | |||
2 | Co-fractionation | [9] | |||
Interacting Protein Name | Elongation factor 1-delta (EEF1D) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | EF.1D; EF1D; FP1047 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [47] | |||
2 | Biochemical Activity | [2] | |||
Interacting Protein Name | Lupus La protein (SSB) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | LARP3; La; La/SSB | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [2] | |||
2 | Biochemical Activity | [48] | |||
Interacting Protein Name | RNA polymerase-associated protein LEO1 (LEO1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RDL | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [2] | |||
2 | Co-fractionation | [10] | |||
Interacting Protein Name | Nucleolar protein 58 (NOP58) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | NOP5; NOP5/NOP58 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [2] | |||
2 | Biochemical Activity | [49] | |||
Interacting Protein Name | Nucleosome assembly protein 1-like 1 (NAP1L1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | NAP1; NAP1L; NRP | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [42] | |||
2 | Co-fractionation | [10] | |||
Interacting Protein Name | Pre-mRNA-splicing factor 38A (PRPF38A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Prp38 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [2] | |||
2 | Co-fractionation | [9] | |||
Interacting Protein Name | Transcription elongation factor SPT5 (SUPT5H) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | SPT5; SPT5H; Tat.CT1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [2] | |||
2 | Co-fractionation | [9] | |||
Interacting Protein Name | Serine/arginine repetitive matrix protein 2 (SRRM2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | 300.KD; CWF21; Cwc21; SRL300; SRm300 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [16] | |||
2 | Biochemical Activity | [2] | |||
Interacting Protein Name | Surfeit locus protein 6 (SURF6) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RRP14 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Biochemical Activity | [2] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. | ||||
REF 2 | A bead-based approach for large-scale identification of in vitro kinase substrates. Proteomics. 2011 Dec;11(24):4632-7. | ||||
REF 3 | An AUTS2-Polycomb complex activates gene expression in the CNS. Nature. 2014 Dec 18;516(7531):349-54. | ||||
REF 4 | Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. J Cell Biol. 1995 Jun;129(6):1617-28. | ||||
REF 5 | A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin. Mol Cell Biochem. 2001 Nov;227(1-2):31-6. | ||||
REF 6 | Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J Biol Chem. 2007 Nov 9;282(45):33227-36. | ||||
REF 7 | The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. J Biol Chem. 2002 Sep 27;277(39):35783-6. | ||||
REF 8 | Regulation of histone deacetylase 2 by protein kinase CK2. J Biol Chem. 2002 Aug 30;277(35):31826-33. | ||||
REF 9 | Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44. | ||||
REF 10 | A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81. | ||||
REF 11 | Mammalian histone deacetylase 1 protein is posttranslationally modified by phosphorylation. Biochem Biophys Res Commun. 2001 May 4;283(2):445-53. | ||||
REF 12 | Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. J Biol Chem. 2001 Dec 14;276(50):47733-41. | ||||
REF 13 | Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. Proteomics. 2005 Apr;5(5):1250-62. | ||||
REF 14 | Direct identification of PTEN phosphorylation sites. FEBS Lett. 2002 Sep 25;528(1-3):145-53. | ||||
REF 15 | Eukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on CK2alpha activity. Biochem J. 2003 Nov 1;375(Pt 3):623-31. | ||||
REF 16 | Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3. | ||||
REF 17 | C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances. Oncogene. 2013 Jun 20;32(25):3101-10. | ||||
REF 18 | Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. Nature. 2014 Dec 11;516(7530):267-71. | ||||
REF 19 | Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage. BMC Mol Biol. 2012 Mar 9;13:7. | ||||
REF 20 | Characterization of protein interaction among subunits of protein kinase CKII in vivo and in vitro. Mol Cells. 1998 Feb 28;8(1):43-8. | ||||
REF 21 | Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO J. 2003 Mar 17;22(6):1302-12. | ||||
REF 22 | Dependence of HSP27 cellular level on protein kinase CK2 discloses novel therapeutic strategies. Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2902-2910. | ||||
REF 23 | Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif. Biochem Biophys Res Commun. 1999 Oct 5;263(3):743-8. | ||||
REF 24 | Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling. FASEB J. 2009 Nov;23(11):3712-21. | ||||
REF 25 | Identification of a CK2 phosphorylation site in mdm2. Eur J Biochem. 1999 Dec;266(2):493-501. | ||||
REF 26 | Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. J Biol Chem. 2000 May 12;275(19):14295-306. | ||||
REF 27 | Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536. | ||||
REF 28 | Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. PLoS Genet. 2013 Mar;9(3):e1003398. | ||||
REF 29 | Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins. Mol Cell Biochem. 1999 Jan;191(1-2):51-8. | ||||
REF 30 | BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels. Mol Cell Biol. 2004 Aug;24(16):6947-56. | ||||
REF 31 | Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells. J Biol Chem. 2013 Feb 1;288(5):2965-75. | ||||
REF 32 | COP9 subunits 4 and 5 target soluble guanylyl cyclase 1 and p53 in prostate cancer cells. Mol Endocrinol. 2014 Jun;28(6):834-45. | ||||
REF 33 | Hsp90 chaperones wild-type p53 tumor suppressor protein. J Biol Chem. 2004 Nov 19;279(47):48836-45. | ||||
REF 34 | Phosphorylation of ribosomal protein L5 by protein kinase CKII decreases its 5S rRNA binding activity. Biochem Biophys Res Commun. 1999 Sep 24;263(2):475-81. | ||||
REF 35 | Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol. 2005 Oct;19(10):2451-65. | ||||
REF 36 | Casein kinase II interacts with the bZIP domains of several transcription factors. Nucleic Acids Res. 1998 Aug 15;26(16):3854-61. | ||||
REF 37 | Distinct organization of DNA complexes of various HMGI/Y family proteins and their modulation upon mitotic phosphorylation. J Biol Chem. 2001 Jan 19;276(3):1984-92. | ||||
REF 38 | Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain. J Biol Chem. 2005 Jun 10;280(23):22205-11. | ||||
REF 39 | pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. Mol Cell. 2007 Oct 12;28(1):15-27. | ||||
REF 40 | Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase. FEBS Lett. 1987 May 11;215(2):241-6. | ||||
REF 41 | HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2. Biol Chem. 2007 Apr;388(4):391-8. | ||||
REF 42 | NAP-2: histone chaperone function and phosphorylation state through the cell cycle. J Mol Biol. 2000 Apr 28;298(2):225-38. | ||||
REF 43 | Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. PLoS One. 2010 Jul 2;5(7):e11418. | ||||
REF 44 | Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling. Mol Cell. 2009 Feb 13;33(3):400-9. | ||||
REF 45 | A CK2-dependent mechanism for degradation of the PML tumor suppressor. Cell. 2006 Jul 28;126(2):269-83. | ||||
REF 46 | Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2. Biochem Biophys Res Commun. 1999 Jun 24;260(1):17-22. | ||||
REF 47 | A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII. Mol Cell Biochem. 1999 Jan;191(1-2):181-6. | ||||
REF 48 | Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity. Cell Death Differ. 2009 Feb;16(2):340-8. | ||||
REF 49 | Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Mol Cell. 2010 Aug 27;39(4):641-52. |
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