Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | DNA topoisomerase II alpha (TOP2A) | Clinical trial | Target Info | ||
| UniProt ID | TOP2A_HUMAN | ||||
| Gene Name | TOP2A | ||||
| Gene ID | 7153 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Histone deacetylase 1 (HDAC1) | Target Info | PPI Info | [1] | |
| DNA topoisomerase II beta (TOP2B) | Target Info | PPI Info | [2] | ||
| Beta-catenin (CTNNB1) | Target Info | PPI Info | [3] | ||
| Interacting Clinical trial Target(s) | Casein kinase II alpha (CSNK2A1) | Target Info | PPI Info | [4] | |
| Interacting Literature-reported Target(s) | JUN activation domain binding protein (COPS5) | Target Info | PPI Info | [5] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Histone deacetylase interacts directly with DNA topoisomerase II. Nat Genet. 2000 Nov;26(3):349-53. | ||||
| REF 2 | Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8288-93. | ||||
| REF 3 | Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. Gastroenterology. 2005 Oct;129(4):1225-36. | ||||
| REF 4 | A bead-based approach for large-scale identification of in vitro kinase substrates. Proteomics. 2011 Dec;11(24):4632-7. | ||||
| REF 5 | Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase II degradation in hepatocellular carcinoma cells. Hepatology. 2011 Jan;53(1):148-59. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.