Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T94980 Target Info
Target Name E3 ubiquitin-protein ligase NEDD4 (NEDD4)
Synonyms Neural precursor cell expressed developmentally down-regulated protein 4; NEDD4-1; NEDD-4; KIAA0093; HECT-type E3 ubiquitin transferase NEDD4; Cell proliferation-inducing gene 53 protein
Target Type Literature-reported Target
Gene Name NEDD4
UniProt ID
NEDD4_HUMAN 
Target Interacting Proteins  Top
Autophagy-related proteins [+] 1 Autophagy-related proteins +
Interacting Target Name Beclin-1 (BECN1) Literature-reported Target Interacting Protein Info
UniProt ID
BECN1_HUMAN 
Synonyms Protein GT197; GT197; Coiled-coil myosin-like BCL2-interacting protein; Coiledcoil myosinlike BCL2interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [2]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Phosphatase and tensin homolog (PTEN) Literature-reported Target Interacting Protein Info
UniProt ID
PTEN_HUMAN 
Synonyms TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; MMAC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Kinases [+] 4 Kinases +
Interacting Target Name Fibroblast growth factor receptor 1 (FGFR1) Successful Target Interacting Protein Info
UniProt ID
FGFR1_HUMAN 
Synonyms N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT-2; FLT2; FLG; FGFR-1; FGFBR; c-fgr; CEK; CD331 antigen; CD331; bFGF-R-1; bFGF-R; BFGFR; Basic fibroblast growth factor receptor 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
Interacting Target Name Tropomyosin-related kinase A (TrkA) Successful Target Interacting Protein Info
UniProt ID
NTRK1_HUMAN 
Synonyms Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; NGF-trk receptor type A; Neurotrophic tyrosine kinase receptor type 1; MTC; High affinity nerve growth factor receptor; gp140trk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
Interacting Target Name Serine/threonine-protein kinase Sgk1 (SGK1) Clinical trial Target Interacting Protein Info
UniProt ID
SGK1_HUMAN 
Synonyms SGK; Serum/glucocorticoid-regulated kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Interacting Target Name Activated CDC42 kinase 1 (ACK-1) Patented-recorded Target Interacting Protein Info
UniProt ID
ACK1_HUMAN 
Synonyms Tyrosine kinase non-receptor protein 2; Tyrosine kinase nonreceptor protein 2; ACK-1; ACK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [11]
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Protein-peptide [13]
3 Reconstituted Complex [13]
Interacting Target Name Mothers against decapentaplegic homolog 7 (SMAD7) Clinical trial Target Interacting Protein Info
UniProt ID
SMAD7_HUMAN 
Synonyms Smad7; SMAD family member 7; SMAD 7; Mothers against DPP homolog 8; Mothers against decapentaplegic homolog 8; MAD homolog 8; hSMAD7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [12]
Interacting Protein Name Mad-related protein 1 (SMAD1) Interacting Protein Interacting Protein Info
UniProt ID
SMAD1_HUMAN 
Synonyms Transforming growth factor-beta-signaling protein 1; Smad1; SMAD family member 1; SMAD 1; Mothers against DPP homolog 1; Mothers against decapentaplegic homolog 1; Mad-related protein 1; MADR1; MADH1; MAD homolog 1; JV4-1; BSP-1; BSP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Yeast two hybrid [16]
References  Top
REF 1 The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy. Autophagy. 2017;13(12):2041-2055.
REF 2 Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1. Biochem J. 2012 Jan 1;441(1):399-406.
REF 3 Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell. 2009 Apr 7;15(4):304-14.
REF 4 Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation. Biochem J. 2008 Sep 1;414(2):221-9.
REF 5 Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity. Sci Signal. 2014 Oct 7;7(346):ra95.
REF 6 Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J. 2011 Jul 15;30(16):3259-73.
REF 7 Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. Sci Signal. 2015 Apr 28;8(374):ra40.
REF 8 Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron. 2006 May 18;50(4):549-59.
REF 9 Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS One. 2010 Aug 13;5(8):e12163.
REF 10 Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. J Biol Chem. 2002 Jan 4;277(1):5-8.
REF 11 HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol. 2010 Mar;30(6):1541-54.
REF 12 NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Biochem J. 2005 Mar 15;386(Pt 3):461-70.
REF 13 A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 2011 Jun 15;25(12):1275-88.
REF 14 USP11 augments TGF signalling by deubiquitylating ALK5. Open Biol. 2012 Jun;2(6):120063.
REF 15 Phospho-Smad1 modulation by nedd4 E3 ligase in BMP/TGF- signaling. J Bone Miner Res. 2011 Jul;26(7):1411-24.
REF 16 Functional proteomics mapping of a human signaling pathway. Genome Res. 2004 Jul;14(7):1324-32. Validation Studies

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