Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Mothers against decapentaplegic homolog 7 (SMAD7) | Clinical trial | Target Info | ||
| UniProt ID | SMAD7_HUMAN | ||||
| Gene Name | SMAD7 | ||||
| Gene ID | 4092 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Histone deacetylase 1 (HDAC1) | Target Info | PPI Info | [1] | |
| Beta-catenin (CTNNB1) | Target Info | PPI Info | [2] | ||
| Interacting Clinical trial Target(s) | TGF-beta receptor type I (TGFBR1) | Target Info | PPI Info | [3] | |
| Interacting Literature-reported Target(s) | E3 ubiquitin protein ligase Itchy (ITCH) | Target Info | PPI Info | [4] | |
| E3 ubiquitin-protein ligase NEDD4 (NEDD4) | Target Info | PPI Info | [4] | ||
| NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) | Target Info | PPI Info | [4] | ||
| Yes-associated protein 1 (YAP1) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The balance between acetylation and deacetylation controls Smad7 stability. J Biol Chem. 2005 Jun 10;280(23):21797-803. | ||||
| REF 2 | Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis. Mol Cell Biol. 2005 Feb;25(4):1475-88. | ||||
| REF 3 | Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling. J Biol Chem. 2004 Jul 23;279(30):31568-74. | ||||
| REF 4 | USP11 augments TGF signalling by deubiquitylating ALK5. Open Biol. 2012 Jun;2(6):120063. | ||||
| REF 5 | Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene. 2002 Jul 25;21(32):4879-84. | ||||
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