Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T01054 Target Info
Target Name NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2)
Synonyms WW domaincontaining protein 2; WW domain-containing protein 2; NEDD4like E3 ubiquitinprotein ligaseWWP2; HECT-type E3 ubiquitin transferase WWP2; Atrophin1interacting protein 2; Atrophin-1-interacting protein 2; AIP2
Target Type Literature-reported Target
Gene Name WWP2
Biochemical Class Acyltransferase
UniProt ID
WWP2_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Arrestin domain-containing protein 1 (ARRDC1) Interacting Protein Interacting Protein Info
UniProt ID
ARRD1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Yeast two hybrid [3]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Phosphatase and tensin homolog (PTEN) Literature-reported Target Interacting Protein Info
UniProt ID
PTEN_HUMAN 
Synonyms TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; MMAC1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
3 Biochemical Activity [6]
4 Reconstituted Complex [6]
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
3 Biochemical Activity [8]
4 Yeast two hybrid [3]
Interacting Target Name Mothers against decapentaplegic homolog 7 (SMAD7) Clinical trial Target Interacting Protein Info
UniProt ID
SMAD7_HUMAN 
Synonyms Smad7; SMAD family member 7; SMAD 7; Mothers against DPP homolog 8; Mothers against decapentaplegic homolog 8; MAD homolog 8; hSMAD7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [8]
Interacting Protein Name POU class 5 homeobox 1 (POU5F1) Interacting Protein Interacting Protein Info
UniProt ID
PO5F1_HUMAN 
Synonyms OCT3; OCT4; OTF.3; OTF3; OTF4; Oct.3; Oct.4
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [10]
2 Reconstituted Complex [10]
Other proteins [+] 3 Other proteins +
Interacting Protein Name Segment polarity protein dishevelled homolog DVL-2 (DVL2) Interacting Protein Interacting Protein Info
UniProt ID
DVL2_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [12]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) Interacting Protein Interacting Protein Info
UniProt ID
HNRL1_HUMAN 
Synonyms E1B.AP5; E1BAP5; HNRPUL1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Yeast two hybrid [3]
Interacting Protein Name PDZ and LIM domain protein 7 (PDLIM7) Interacting Protein Interacting Protein Info
UniProt ID
PDLI7_HUMAN 
Synonyms LMP1; LMP3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Yeast two hybrid [3]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4146-51.
REF 3 Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80.
REF 4 Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. Proteomics. 2005 Apr;5(5):1250-62.
REF 5 SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. 2017 Mar 14;8(11):17651-17664.
REF 6 Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases. Biochemistry. 2016 Jul 5;55(26):3658-66.
REF 7 Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. J Cell Biochem. 2008 Oct 1;105(2):596-611.
REF 8 Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGF signalling and EMT. Oncogene. 2011 May 26;30(21):2451-62.
REF 9 USP11 augments TGF signalling by deubiquitylating ALK5. Open Biol. 2012 Jun;2(6):120063.
REF 10 WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 2009 May;19(5):561-73.
REF 11 WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and Np73 levels. Mol Cell Biol. 2014 Oct 1;34(19):3754-64.
REF 12 Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled. Open Biol. 2015 Dec;5(12):150185.

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