| References |
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| REF 1 |
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. EMBO Rep. 2006 Nov;7(11):1147-53.
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| REF 2 |
AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS One. 2008 Jul 16;3(7):e2735.
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| REF 3 |
Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners. EMBO Rep. 2015 Dec;16(12):1699-712.
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| REF 4 |
Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem. 2012 Mar 16;287(12):9013-27.
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| REF 5 |
The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Mol Biol Cell. 2009 Mar;20(5):1324-39.
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| REF 6 |
Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity. Cancer Res. 2011 Mar 1;71(5):2010-20.
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| REF 7 |
Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth. J Biol Chem. 2013 May 24;288(21):15181-93.
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| REF 8 |
Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 2017 May 2;114(18):4691-4696.
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| REF 9 |
Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4870-5.
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| REF 10 |
Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4162-7.
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| REF 11 |
The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation. FASEB J. 2007 Sep;21(11):2849-62.
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| REF 12 |
WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol. 2005 Aug;25(16):7092-106.
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| REF 13 |
The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X. J Biol Chem. 2006 Dec 15;281(50):38738-47.
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| REF 14 |
Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling. Cell Signal. 2009 Aug;21(8):1326-36.
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| REF 15 |
The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12753-8.
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| REF 16 |
Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant. Cell Cycle. 2010 Sep 15;9(18):3730-9.
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| REF 17 |
Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interaction. Cell Cycle. 2012 Oct 1;11(19):3638-48.
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| REF 18 |
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 2005 Feb 23;24(4):836-48.
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| REF 19 |
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11280-5.
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| REF 20 |
Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction. J Cell Physiol. 2013 Jul;228(7):1443-51.
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| REF 21 |
Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. Cell Res. 2010 Mar;20(3):332-44.
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| REF 22 |
Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination. Biochem Biophys Res Commun. 2008 Oct 24;375(3):326-30.
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| REF 23 |
Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2. Genomics. 2001 Apr 15;73(2):238-41.
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| REF 24 |
USP11 augments TGF signalling by deubiquitylating ALK5. Open Biol. 2012 Jun;2(6):120063.
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| REF 25 |
AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism. J Biol Chem. 2005 Jul 29;280(30):27645-53.
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| REF 26 |
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. J Immunol. 2015 Mar 1;194(5):2160-7.
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| REF 27 |
Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase. J Biol Chem. 2018 Jan 19;293(3):1100-1105.
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| REF 28 |
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell. 2007 Aug 24;130(4):651-62.
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| REF 29 |
Itch self-polyubiquitylation occurs through lysine-63 linkages. Biochem Pharmacol. 2008 Dec 1;76(11):1515-21.
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| REF 30 |
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. Mol Cell. 2007 Nov 9;28(3):386-97.
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| REF 31 |
System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol Cell. 2016 Apr 7;62(1):121-36.
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| REF 32 |
The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J Biol Chem. 2010 Mar 19;285(12):8869-79.
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| REF 33 |
Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations. Biochem J. 2015 Apr 15;467(2):345-52.
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| REF 34 |
HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death. J Biol Chem. 2011 Dec 23;286(51):44086-94.
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| REF 35 |
Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation. Mol Cell. 2004 Sep 10;15(5):825-31.
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| REF 36 |
Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation. J Biol Chem. 2015 Sep 25;290(39):23875-87.
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| REF 37 |
Itch/-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis. Nat Commun. 2018 Mar 7;9(1):976.
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| REF 38 |
A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics. 2012 Aug;11(8):329-41.
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| REF 39 |
Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming. Nat Struct Mol Biol. 2013 Jun;20(6):696-701.
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| REF 40 |
A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5.
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| REF 41 |
Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem J. 2016 Jan 15;473(2):179-87.
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| REF 42 |
Identification of Redox and Glucose-Dependent Txnip Protein Interactions. Oxid Med Cell Longev. 2016;2016:5829063.
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| REF 43 |
A novel interaction between atrophin-interacting protein 4 and beta-p21-activated kinase-interactive exchange factor is mediated by an SH3 domain. J Biol Chem. 2007 Sep 28;282(39):28893-903.
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| REF 44 |
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch. J Biol Chem. 2017 Apr 14;292(15):6325-6338.
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| REF 45 |
Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region. Biochemistry. 2015 Dec 22;54(50):7345-54.
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| REF 46 |
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem. 2003 Jun 20;278(25):23196-203.
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| REF 47 |
Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal. Oncogene. 2011 Jan 6;30(1):65-76.
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| REF 48 |
Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2. Cancer Res. 2016 Nov 1;76(21):6278-6289.
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| REF 49 |
The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability. FEBS Lett. 2015 Jan 2;589(1):94-101.
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| REF 50 |
ASPP2 suppresses invasion and TGF-1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer. Cancer Lett. 2017 Jul 10;398:52-61.
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| REF 51 |
The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein. Mol Cell Biol. 2012 Oct;32(19):3903-12.
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| REF 52 |
Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled. Open Biol. 2015 Dec;5(12):150185.
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